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| 1 | Design and baseline data of a populationbased metabonomics study of eye diseases in eastern China: the Yueqing Ocular Diseases Investigation显示文摘Background:China is undergoing a massive transition toward an urban and industrial economy.These changes will restructure the demographics and economy which will eventually influence the future patterns of disease.The risk factors of vision-impairing eye diseases remain ambiguous and poorly understood.Metabolomics is an ideal tool to understand and shed light on the ocular disease mechanisms for earlier treatment.This article aims to describe the design,methodology and baseline data of the Yueqing Ocular Diseases Investigation(YODI),a developed county population-based study to determine the prevalence and primary causes of visual impairment;also with metabonomics analysis we aimed to identify,predict and suggest some preventive biomarkers that cause blindness.Methods:A population-based,cross-sectional study.Randomized clustering sampling was used to identify adults aged 50 years and older in Xiangyang Town,Yueqing county-level City.The interviews covered demographic,behavioral,ocular risk factors and mental health state.The ocular examination included visual acuity,autorefraction,intraocular pressure,anterior and posterior segment examinations,fundus photography,retinal tomography and angiography,and visual field testing.Anthropometric measurements included height and weight,waist and hip circumference,blood pressure,pulse rate,electrocardiogram,and abdominal ultrasound scan.A venous blood sample was collected for laboratory tests and metabonomics studies.Results:Of the 5319 individuals recruited for the YODI,4769(89.7%)subjects were enrolled for analyses.The median age was 62.0 years,and 45.6%were male.The educational level of illiteracy or semi-illiteracy,primary,middle and high school or above was 29.8%,45.5%,20.1%,and 3.3%,respectively.Majority of the participants were female,younger,and less educated when compared with nonparticipants.The average body mass index and waist-hip ratios were 24.4±3.4 kg/m^(2) and 0.9±0.1 respectively.Blood sample collection reached a sample size of 1909(479 from subjects with selfreported diabetes and 1430 from one-third of the 4290 subjects without self-reported diabetes).Conclusions:The YODI provides population-based data with a high response rate(89.7%)on the prevalence and primary causes of major vision-impairing eye diseases in developed county areas in eastern China.Metabonomics analysis from YODI will provide further association of metabolic characteristics with the visual impairment eye diseases.The risk prediction model could be created and has the potential to be generalized to developed eastern areas in China for prevention. | Yuxuan Deng Yuanbo Liang Sigeng Lin Liang Wen Jin Li Yue Zhou Meixiao Shen Jingwei Zheng Kemi Feng Yanting Sun Kwapong Willaim Robert Jia Qu Fan Lu | 2020 | Eye and Vision2020，7，1： | 4 |
| 2 | Comparison of parametric and nonparametric models for traffic flow forecasting显示文摘 | SMITH B L WILLAIMS B M OSWALD R K | 2003 | Transportation Research Part C2003，10，4： | 1 |
| 3 | Ab initio study of helium in ct-Fe: Dissolution, migration, and clustering with vacancies显示文摘 | FU C C WILLAIME F | 2005 | Phys Rev B2005，72，06： | 1 |
| 4 | Organisation of carbon and boron nitride layers in mixed nanoparticles and nanotubes synthesised by arc-discharge 显示文摘 | Suenaga K Willaime F Loiseau A | 1999 | Applied Physics A1999，68，： | 1 |
| 5 | Stability and Mobility of Mono-and Di-Interstitials in α-Fe显示文摘 | Fu C C Willaime F | 2004 | Physical Review Letters2004，92，17： | 1 |
| 6 | First principles calculations in iron: Structure and mobility of defect clusters and defect complexes for kinetic mo- delling显示文摘 | Fu C C Willaime F | 2005 | Phys Rev B2005，72，： | 1 |
| 7 | Boron Nitride Nanotubes with Reduced Number of Layers Synthesized by Arc Discharge 显示文摘 | Loiseau A Willaime F Demoncy N | 1996 | Phys Rev Lett1996，76，25： | 1 |
| 8 | Synthesis of Nanoparticles and Nanotubes with Well-separated Layers of Boron Nitride and Carbon显示文摘 | Suenage K Colliex C Demoncy N Loiseau A Pascard H Willaime F | 1997 | Science1997，278，： | 1 |
| 9 | Ordered and disordered patterns in two-phase flows in microchannels 显示文摘 | DREYFUS R TABELING P WILLAIME H | 2003 | Phys RevLett2003，9014，14： | 1 |
| 10 | Non-glide effects and dislocation core fields in BCC metals显示文摘A hallmark of low-temperature plasticity in body-centered cubic(BCC)metals is its departure from Schmid’s law.One aspect is that non-glide stresses,which do not produce any driving force on the dislocations,may affect the yield stress.We show here that this effect is due to a variation of the relaxation volume of the 1/2<111>screw dislocations during glide.We predict quantitatively nonglide effects by modeling the dislocation core as an Eshelby inclusion,which couples elastically to the applied stress.This model explains the physical origin of the generalized yield criterion classically used to include non-Schmid effects in constitutive models of BCC plasticity.We use first-principles calculations to properly account for dislocation cores and use tungsten as a reference BCC metal.However,the methodology developed here applies to other BCC metals,other energy models and other solids showing nonglide effects. | Antoine Kraych Emmanuel Clouet Lucile Dezerald Lisa Ventelon François Willaime David Rodney | 2019 | npj Computational Materials2019，，1： | 1 |
| 11 | Nasal hypersensitivity in wood furniture workers显示文摘 | Willaim E | 1989 | Environ Res1989，61，4： | 1 |
| 12 | Filled and mixed nanotubes:from TEM studies to the growth mechanism within a phase-diagram approach 显示文摘 | Loiseau A Willaime F | 2000 | Applied Surface Science2000，164，： | 1 |
| 13 | Root-growth mechanism for single-wall carbon nanotubes显示文摘 | GAVILLET J LOISEAU A JOURNET C WILLAIME F DUCASTELLE F CHARLIER J C | 2001 | Phys Rev Lett2001，87，27： | 1 |
| 14 | Ordered and disor- dered patterns in two-phase flows in microchannels 显示文摘 | Dreyfus R Tabeling P Willaime H | 2003 | Physical Review Letters2003，90，14： | 1 |
| 15 | Geometry of isothermal and isoconcentration on surfaces in thermal turbulence显示文摘 | Gluckman B J Willaime H Gollub J P | | 0，，： | 1 |
| 16 | Boron nitride nanotubes with reduced numbers of layers synthesized by arc discharge显示文摘 | LOISEAU A WILLAIME F DEMONCY N | 1996 | Phys Rev Lett1996，76，25： | 1 |
| 17 | Geometry of isothermal and isoconcentration surfaces in thermal turbulence 显示文摘 | GLUCKMAN B J WILLAIME H GOLLUB J P | 1993 | Phys Fluids A1993，5，3： | 1 |
| 18 | Ceramide-indueed apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation 显示文摘 | Willaime S Vanhoutte P Caboehe J | 2001 | Eur J Neurosei2001，13，11： | 1 |
| 19 | Passive scalar intermittency in low temperature helium flows 显示文摘 | MOISY F WILLAIME H ANDERSEN J S | 2001 | Phys Rev Lett2001，86，： | 1 |
| 20 | Ordered and disordered patterns in two-phase flows in microchannels显示文摘 | DREYFUS R TABELING P WILLAIME H | 2003 | Physical Review Letters2003，90，14： | 1 |
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