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| 1 | MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside显示文摘MicroRNAs(miRNAs) are small, single-stranded, noncoding RNAs that can post-transcriptionally regulate the expression of various oncogenes and tumor suppressor genes. Dysregulated expression of many miRNAs have been shown to mediate the signaling pathways critical in the multistep carcinogenesis of colorectal cancer(CRC). MiR NAs are stable and protected from RNase-mediated degradation, thereby enabling its detection in biological fluids and archival tissues for biomarker studies. This review focuses on the role and application of miRNAs in the prognosis and therapy of CRC. While stage Ⅱ CRC is potentially curable by surgical resection, a significant percentage of stage Ⅱ CRC patients do develop recurrence. MiRNA biomarkers may be used to stratify such high-risk population for adjuvant chemotherapy to provide better prognoses. Growing evidence also suggests that miRNAs are involved in the metastatic process of CRC. Certain of these miRNAs may thus be used as prognostic biomarkers to identify patients more likely to have micro-metastasis, who could be monitored more closely after surgery and/or given more aggressive adjuvant chemotherapy. Intrinsic and acquired resistance to chemotherapy severely hinders successful chemotherapy in CRC treatment. Predictive miRNA biomarkers for response to chemotherapy may identify patients who will benefit the most from a particular regimen and also spare the patients from unnecessary side effects. Selection of patients to receive the new targeted therapy is becoming possible with the use of predictive miRNA biomarkers. Lastly, forced expression of tumor suppressor miRNA or silencing of oncogenic miRNA in tumors by gene therapy can also be adopted to treat CRC alone or in combination with other chemotherapeutic drugs. | Kenneth KW To Christy WS Tong Mingxia Wu William CS Cho | 2018 | World Journal of Gastroenterology2018，24，27： | 29 |
| 2 | Effect of St John's wort and ginseng on the pharmacokinetics and phar- macodynamics of warfarin in healthy subjects显示文摘 | Jiang X Williams KM Liauw WS | 2004 | Br J Cl- in Pharmaeol2004，57，5： | 1 |
| 3 | Effect of ginkgo and gin- ger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects 显示文摘 | Jiang X Williams KM Liauw WS | 2005 | Br J Clin Pharmacol2005，59，4： | 1 |
| 4 | Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects 显示文摘 | Jiang X Williams KM Liauw WS | 2004 | Br J Clin Pharmacol2004，57，： | 1 |
| 5 | Aquaretic Effect of Lixivaptan,an Oral,Non-Peptide,Selective V2 Receptor Vasopressin Antagonist,in New York Heart Associaion Functional Class Ⅱ and Ⅲ Chronic Heart Failure Patients显示文摘 | William TA Alireza AS Robert WS | 2006 | Am Coll Cardiol2006，47，8： | 1 |
| 6 | Streaming potentials and the elec- tromechanical response of physiologically moist bone 显示文摘 | Gross D Williams WS | 1982 | J Biomech1982，15，4： | 1 |
| 7 | Effects of St John's wort and CYP2C9 genotype on the pharmacokinetics and pharmacodynamics of gliclazide 显示文摘 | Xu H Williams KM Liauw WS | 2008 | Br J Pharmacol2008，153，7： | 1 |
| 8 | Effect of St John's wort and ginseng on the pharmaco kinetics and pharmacodynamics of warfarin in healthy subjects 显示文摘 | Jiang X Williams KM Liauw WS | 2004 | Br J Clin Pharmacol2004，57，： | 1 |
| 9 | β-Cell function and the development of diabetes-related complications in the diabetes control and complications trial显示文摘 | Michael WS Shalamar S William T | 2003 | Diabetes Care2003，26，3： | 1 |
| 10 | Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects显示文摘 | Jiang X Williams KM Liauw WS | 2004 | Br J Clin Pharmacol2004，57，： | 1 |
| 11 | Diagnosis of human Ehrlichia by PCR assay of acute-phase serum显示文摘 | James AC William LN John WS | 1999 | J Clin Microbiol1999，37，： | 1 |
| 12 | Involvement of CtBP1 in the transcriptional activation of the MDR1 gene in human multidrug resistant cancer cells显示文摘 | WEI J KATHLEEN WS WILLIAM N | 2007 | Biochem Pharmacol2007，74，6： | 1 |
| 13 | Effect of ginkgo and ginger on the pharmacokinetics and phannacodynamics of warfarin in healthy subjects显示文摘 | Jiang X Williams KM Liauw WS | 2005 | Br J Clin Pharmacol2005，59，： | 1 |
| 14 | Differential Expression of Matrix Metalloproteinases and Their Tissue-Derived Inhibitors in Cutaneous Wound Repair显示文摘 | Chia S William WS Xinli Z | 2000 | Plast Reconstr Surg2000，105，： | 1 |
| 15 | Effect of St John's wort and ginseng on the pharmacikinetics and phamlacidynamics of warfarin in heahhy subjects 显示文摘 | Jiang X Williams KM Liauw WS | 2004 | Br J Clin Pharmaco12004，57，5： | 1 |
| 16 | Clinical masking in speech audiometry:a simplified approach 显示文摘 | William S Yacullo WS | 1999 | American Journal of Audiology1999，8，： | 1 |
| 17 | Nursing students' and clinical educators' perceptions of characteristics of effective clinical educators in an Australian university school of nursing显示文摘 | Lee WS Cholowski K Williams AK | 2002 | Journal of Advanced Nursing2002，39，5： | 1 |
| 18 | Common gynecologic infections显示文摘 | Biggs WS Williams RM | 2009 | Prim Care2009，36，1： | 1 |
| 19 | Nursing studentseand clinical educatorscperceptions of characteristics of effective clinical educators in an Australian university school of nursing显示文摘 | Lee WS Cholowski K Williams AK | 2002 | J Adv Nurs2002，39，5： | 1 |
| 20 | Streaming potential and the electromechanical response of physiologically moist bone 显示文摘 | Gross D Williams WS | 1982 | J Biomech1982，15，： | 1 |
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