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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Simultaneous radiotherapy for prostate cancer:125I prostate implant followed by external-beam radiation显示文摘 | Levinson AK Williams WH | 1998 | Cancer J Sci Am1998，4，6： | 1 |
| 3 | Off-pumpcoronary artery bypass grafting provides complete revascularization with reduced myocardial injury,transfusion requirements,and length of stay:a prospective randomized comparison of two hundred unselected patients undergoing off-pump versus conventional coronary artery bypass grafting显示文摘 | Williams WH Duke PG | 2003 | J Thorac Cardiovasc Surg2003，125，： | 1 |
| 4 | Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia显示文摘 | Meck WH Williams CL Cermak JM et a1 | 2007 | Front Integr Neurosci2007，，： | 1 |
| 5 | Effect of atropine and/or physostigmine on cerebral acetylcholine in rats poisoned with Soman显示文摘 | Larrel WH William CH David LS | 1978 | Life Sci1978，22，10： | 1 |
| 6 | Off-pump vs conven tional coronary artery bypass grafting:early and1-year graft paten cy,cost,and quality-of-life outcomes:a randomized trial显示文摘 | Puskas JD Williams WH Mahoney EM | 2004 | JAMA2004，4，21： | 1 |
| 7 | Off - pump vs conventional coronary artery bypass grafting: Early and 1 - year graft patency, cost, and quality- of- life outcomes, a randomized trial显示文摘 | Puskas J Williams WH Mahoney EM | 2004 | JAMA2004，291，： | 1 |
| 8 | Head and neck mucosal melanoma显示文摘 | William MM Robert JA Russell WH | 2005 | Am J Clin Oncol2005，28，： | 1 |
| 9 | Experimental model of bladder outflow tract obstruction in the guinea-pig显示文摘 | Williams JH Turner WH Sainsbury GM | 1993 | Br J Urol1993，71，5： | 1 |
| 10 | Offpump vs conventional coronary artery bypassgrafting:early and 1-year graft patency,cost,and qualityof-life outcomes:a randomized trial显示文摘 | Puskas JD Williams WH Mahoney EM | 2004 | JAMA2004，291，15： | 1 |
| 11 | Pulmonary outcomes of off - pump vs on - pump coronary artery bypass surgery in a randomized trial 显示文摘 | Staton GW Williams WH Mahoney EM | 2005 | Chest2005，127，3： | 1 |
| 12 | Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries显示文摘 | Bickell WH William H Wall M | 1994 | The New England Journal of Medicine1994，331，17： | 1 |
| 13 | Defini- tive radiotherapy for nasopharyngeal carcinoma 显示文摘 | William MM Christopher GM Russel WH | 2006 | Am J Clin Oneol2006，29，6： | 1 |
| 14 | Off-pump coronary artery bypass grafting provides complete revascularization with reduced myocardial injury,transfusion requirements,and length of stay:a prospective randomized comparison of two hundred unselected patients undergoing off-pump versus conve显示文摘 | Puskas JD Williams WH Duke PG | | 0，，： | 1 |
| 15 | Definitive radiotherapy for nasopharyngeal carcinoma显示文摘 | William MM Christopher GM Russel WH | 2006 | Am J Clin Oncol2006，29，6： | 1 |
| 16 | Off-pump vs con- ventional coronary artery bypass grafting: Early and l-year graft patency, cost, and quality-of-life outcomes: A randomized trial 显示文摘 | Puskas JD Williams WH Mahoney EM | 2004 | JAMA2004，291，15： | 1 |
| 17 | A biochemical method tor determining indigestible residue (crude fiber) in feces: Lignin, cellulose, non - water - soluble hemicelluloses显示文摘 | Williams RD Olmsted WH | 1935 | Journal of Biological Chemis- try1935，108，： | 1 |
| 18 | Off pump vs conventional coronary artery bypass grafting: early and 1- year graft patency, cost, and quality-of- life outcomes: a randomized trial 显示文摘 | Puskas JD Williams WH Mahoney EM | 2004 | JAMA2004，291，： | 1 |
| 19 | Off-pump coronary ar- tery bypass grafting provide complete revascularization with reduced myocardial injury, transfusion requirement, and length of stay : a prospective randomized comparison of two hurdend unselected pa- tients undergoing off-pump versus conventional coronary artery by- pass grafting显示文摘 | Puskas JD Williams WH Duke PG | 2003 | J Thorac Cardiovasc Surg2003，125，4： | 1 |
| 20 | Off-pump versus conventional coronary artery bypass grafting: early and 1-year graft patency, cost, and quality-of-life outcomes: a randomized trial显示文摘 | Puskas JD Williams WH Mahoney EM | 2004 | JAMA2004，291，15： | 1 |
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