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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Measles among adults, UnitedStates, 1985 -1995显示文摘 | Miller M Williams WW Redd SC | 1999 | Am J Prev Med1999，17，： | 1 |
| 3 | Nonlinear magic: mul- tiphoton microscopy in the biosciences 显示文摘 | Zipfel WR Williams RM Webb WW | 2003 | Nature Biotechnology2003，21，： | 1 |
| 4 | Measles among adults, United States, 1985-1995 显示文摘 | Miller M Williams WW Redd SC | 1999 | Am J Prey Med1999，17，2： | 1 |
| 5 | Intercellular adhesion molecule-1 deficient mice are protected against ischemic renal injury 显示文摘 | Kelly KJ Williams WW Jr Coluin RB | 1996 | J Clin Invest1996，97，4： | 1 |
| 6 | Reproductive and contraceptive characteristics of premenopausal kidney transplant recipients显示文摘 | Mattix Kramer HJ Tolkoff-Rubin NE Williams WW | 2003 | Prog Transplant2003，13，3： | 1 |
| 7 | Sensory pathways in the spinal accessory nerve显示文摘 | Bremner-Smith AT Unwin A J Williams WW | 1999 | J Bone Joint Surg(Br)1999，81，2： | 1 |
| 8 | 2-photon molecular excitation provides intrinsic 3-dimensional resolution for laser-based microscopy and microphotochemistry显示文摘 | Williams RM Piston DW Webb WW | 1994 | FASEB J1994，8，： | 1 |
| 9 | Safety and efficacy of the extracoporeal liver assist device(ELAD)in patients with acute on chronic liver failure显示文摘 | Hillebrand DJ Frederick RT Williams WW | | 0，，： | 1 |
| 10 | Renal thrombotic microangiopathy associated with anticardiolipin antibodies in hepalitis C-positive renal allograft recipients显示文摘 | Baid S Pascual M Williams WW Jr | 1999 | J Am Soc Nephrol1999，10，1： | 1 |
| 11 | Measles among adults,United States,1985-1995显示文摘 | Miller M Williams WW Redd SC | 1999 | Am J Prev Med1999，17，2： | 1 |
| 12 | Guideline for infection control in health care personnel, 1998显示文摘 | Tablan OC Williams WW | 1998 | Am J Infect Control1998，26，3： | 1 |
| 13 | Measles among adults, Unit- ed State,1985 - 1995 显示文摘 | Miller M Williams WW Redd SC | 1999 | Am J Prev Med1999，17，： | 1 |
| 14 | Nonlinear magic: multiphoton microscopy in the biosciences 显示文摘 | Zipfel WR Williams RM Webb WW | 2003 | Nature Biotechnol2003，21，： | 1 |
| 15 | Intercellular adhesion moleculs-1-deficient mice are protected against ischemic renal injury显示文摘 | Kelly KJ Williams WW Jr Colvin RB | | 0，，04： | 1 |
| 16 | N - hydroxy - 4 - aminobiphenyl - DNA binding in human p53 gene: sequence preference and the effect of c5 cotosine methylation显示文摘 | Feng ZH Hu WW William N | 2002 | Biochem2002，41，： | 1 |
| 17 | A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults 显示文摘 | Oxman MN Levin MJ Johnson GR Schmader KE Straus SE Gelb LD Arbeit RD Simberkoff MS Gershon AA Davis LE Weinberg A Boardman KD Williams HM Zhang JH Peduzzi PN Beisel CE Morrison VA Guatelli JC Brooks PA Kauffman CA Pachucki CT Neuzil KM Betts RF Wright PF Griffin MR Brunell P Soto NE Marques AR Keay SK Goodman RP Cotton DJ Gnann JW Jr Loutit J Holodniy M Keitel WA Crawford GE Yeh SS Lobo Z Toney JF Greenberg RN Keller PM Harbecke R Hayward AR Irwin MR Kyriakides TC Chan CY Chan IS Wang WW Annunziato PW Silber JL Shingles Prevention Study Group | 2005 | New Engl J Med2005，352，22： | 1 |
| 18 | Intercellular adhesion molecule-1-1dficient mice are protected against ischemic renal injury显示文摘 | Kelly KJ Williams WW Colvin RB | 1996 | J Clin Invest1996，15，2： | 1 |
| 19 | Multiphoton microscopy in biological research显示文摘 | Williams RM Zipfel WR Webb WW | 2001 | Curr Opin Chem Biol2001，5，： | 1 |
| 20 | Reproductive and contraceptive characteristics of premenopausal kidney transplant recipients 显示文摘 | Mattix KHJ Tolkoff-Rubin NE Williams WW | 2003 | Prog Transplant2003，13，3： | 1 |
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