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| 1 | Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis显示文摘Systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated cholangitis.For steroid-dependent disease,azathioprine has been used for maintenance of remission.Mycophenolate mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte production.Introduction of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse events.The patient was managed without a biliary stent.However,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per day.In the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the steroids.Mycophenolate mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis. | Jamie B Sodikoff Steven A Keilin Sheila J Bharmal Melinda M Lewis Gottumukkala S Raju Field F Willingham | 2012 | World Journal of Gastroenterology2012，18，18： | 6 |
| 2 | Effects of ectopic overexpression of p21(WAF1/CIP1) on aneuploidy and the malignant phenotype of human brain tumor cells显示文摘 | Chen J Willingham T Shuford M | 1996 | Oncogene1996，13，7： | 1 |
| 3 | Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates显示文摘 | LEE R G WILLINGHAM M C DAVIS M A | 2000 | J Lipid Res2000，41，12： | 1 |
| 4 | Development of Herceptin resistance in breast cancer cells显示文摘 | Kute T Lack C M Willingham M | 2004 | Cytometry Part A2004，57，2： | 1 |
| 5 | Tumor suppression and inhibition of aneuploid cell accumulation in human brain tumor cell by ectopic overepression of the cyclin-dependent kinase inhibitor p27显示文摘 | Chen J Willingham J Shuford M | 1996 | J Clin Invest1996，97，8： | 1 |
| 6 | Tumor suppression and inhibition of aneuploid cell accumulation in human brain tumor cells by ectopic overexpression of the cyclin-dependent kinase inhibitor p27KIP1显示文摘 | Willingham T Shuford M | 1996 | J-Clin-Invest1996，97，8： | 1 |
| 7 | Therapy of patients with T-cell lymphomas and leukemias using an anti-CD7 monoclonal antibody-ricin A chain immunotoxin显示文摘 | Laver JH Willingham M | 1997 | Leukemia Lymphoma1997，26，： | 1 |
| 8 | Tumur suppression and inhibition of aneuploid cell accumulation in human brain tumor cells by ectopic overexpression of the cyclln-dependent kinase inhibitor p27KIP1显示文摘 | CHEM J WILLINGHAM T SHUFORD M | 1996 | J Clin Invest1996，97，4： | 1 |
| 9 | Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice显示文摘 | Cui Z Willingham M C Hicks A M Alexander-Miller M A Howard T D Hawkins G A | 2003 | Proc Natl Acad Sci USA2003，100，： | 1 |
| 10 | Tumor suppression and inhibition of aneuploid cell accumulation in human brain tumor cells by ectopic overexpression of the cyclin-dependent kinase in- hibitor p27KIP1 显示文摘 | Chen J Willingham T Shuford M | 1996 | J Clin Invest1996，97，8： | 1 |
| 11 | Chromosome aberrations of clonal origin are present in astronauts' blood lymphocytes显示文摘 | GEORGE K DURANTE M WILLINGHAM V | 2004 | Cytogenet Genome Res2004，104，14： | 1 |
| 12 | Auditors' Experience with Material Irregularities: Frequency, Nature, and Detectability显示文摘 | Loebbecke J K M Eining J J Willingham | 1989 | Auditing1989，，9： | 1 |
| 13 | Tumor suppression and inhibition of aneuploid cell accumulation in human brain tumor cells by ectopic overexpression of the cyclin-dependent kinase inhibitor p27KIP1显示文摘 | Willingham T Shuford M | 1996 | J Clin Invest1996，97，： | 1 |
| 14 | Transferable anticancer innate immunity in spontaneous regression/complete resistance mice显示文摘 | Hicks A M Riedlinger G Willingham M C Alexander-Miller M A Von Kap-Herr C Pettenati M J | 2006 | Proc Natl Acad Sci USA2006，103，： | 1 |
| 15 | Influence of row spacing on growth,light and water use by sorghum显示文摘 | MCGOWAN M TAYLOR H M WILLINGHAM J | 1991 | Journal of Agricultural Science1991，116，： | 1 |
| 16 | The effect of aging on cellular immunity against cancer in SR/CR mice显示文摘 | Cui Z Willingham M C | 2004 | Cancer Immunol Immunother2004，53，： | 1 |
| 17 | Auditor's experience with material irregularities: frequency, nature and detectability 显示文摘 | Loebbecke J Eining M Willingham J | 1989 | Auditing: A Journal of Practice & Theory1989，9，： | 1 |
| 18 | Cytochemical Methods for the Detection of Apoptosis显示文摘 | WILLINGHAM M C | 1999 | J Histochem Cytochem1999，47，9： | 1 |
| 19 | Effector mechanisms of the anti-cancer immune responses of macrophages in SR/CR mice显示文摘 | Hicks A M Willingham M C Du W Pang C S Old L J Cui Z | 2006 | Cancer Immun2006，6，： | 1 |
| 20 | Cyclic AMP and cell behavior in cultured cells显示文摘 | Willingham M C | 1976 | Int Rev Cytol1976，44，： | 1 |
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