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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 3 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 4 | Rapid evolution of animal mitochondrial DNA 显示文摘 | BROWN W M GEORGE J R WILSON A C | 1979 | Proc Nat Acad Sci USA1979，76，19： | 2 |
| 5 | Polymorphic sites and the mechanism of evolution in human mitochondrial DNA 显示文摘 | Cano R L Brown W M Wilson A C | 1984 | Genetics1984，106，： | 2 |
| 6 | Spatial Sensitivity of the Gravity Recovery and Climate Experiment (GRACE) Time-variable Gravity Observations显示文摘 | Chen J L Wilson C R Famiglictti J S | 2005 | Journal of Geophysical Research2005，110，： | 1 |
| 7 | A Printed Circuit Board App,-oach to Measuring Current Distribution in a Fuel Cell显示文摘 | Cleghorn S J C Derouin C R Wilson M S | 1998 | Journal of Applied Electrochemistry1998，28，1： | 1 |
| 8 | Microdosimetric properties of ionizing electrons in water显示文摘 | STEWART R D WILSON W E MCDONALD J C | 2002 | Phys Med Biol2002，47，1： | 1 |
| 9 | Modeling of variable speed air-to-water heat pump systems显示文摘 | Tassou S A Marquand C J Wilson D R | 1982 | J Institute of Energy1982，55，42： | 1 |
| 10 | Pattern Vectors from Algebraic Graph Theory显示文摘 | Wilson R C Hancock E R Luo B | 2005 | IEEE Transactions on Pattern Analysis and Machine Intelligence2005，27，： | 1 |
| 11 | Testing the beneficial acclimation hypothesis 显示文摘 | Wilson R S Franklin C E | 2002 | Trends in Ecol & Evol2002，17，2： | 1 |
| 12 | Comparative sub- chronic studies on 2,4-dichlorophenoxyacetic acid, amine, and ester in rats显示文摘 | Charles J M Cunny H C Wilson R D | 1996 | Fundam Appl Toxicol1996，33，2： | 1 |
| 13 | 2005 Drought event in the Amazon River basin as measured by GRACE and esti- mated by climate models 显示文摘 | CHEN J L WILSON C R TAPLEY B D | 2009 | Journal of Geophysical Research: Solid Earth2009，114，05： | 1 |
| 14 | Low degree gravitational changes from GRACE: validation and interpretation显示文摘 | CHEN J L WILSON C R TAPLEY B D | 2004 | Geophy Res Lett2004，31，22： | 1 |
| 15 | 医疗卫生保健文化的反思及促进健康与文化融合的建议显示文摘1医疗卫生保健文化的反思1.1健康文化与医学知识如果医务人员有充足的时间对患者进行诊断并帮助患者进行社区护理,就可在节省卫生费用的同时改善健康结果。整合型社区护理能缩小不同文化背景和群体健康需求的差异。然而,全球范围内对整合型社区护理的投入较少,原因之一就是20世纪对临床服务的重视弱化了卫生服务提供过程中的同情心理。当然,患者也对医学知识存在显性和隐性的影响(特别是当其因不遵医嘱而受到指责时)。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson JWoolf K | 2016 | 中国卫生政策研究2016，9，4： | 1 |
| 16 | Human and machine recognition of faces: a survey显示文摘 | Chellappa R Wilson C L Sirohey S | 1995 | Proc IEEE1995，83，5： | 1 |
| 17 | Methylation and demethylation in theregulation of genes,cells,and responses in the immune system显示文摘 | Fitzpatrick D R Wilson C B | 2003 | ClinImmunol2003，109，1： | 1 |
| 18 | Amplification of the inosinate dehydrogenase fene in Trypanosoma brucei gambiense due to an increase in chromosome copy number 显示文摘 | Wilson K Berens R Sifri C D | 1994 | J Biol Chem1994，269，28： | 1 |
| 19 | Dynamic analysis of a slope failure from the 6 August 1979 Coyote Lake, California, earthquake 显示文摘 | Wilson R C Keefer D K | 1983 | Seismological Society of America Bulletin1983，73，3： | 1 |
| 20 | Comparison of the performance of capacity controlled and conventional on/off controlled heat pumps显示文摘 | Tassou S A Marquand C J Wilson D R | 1983 | Applied Energy1983，14，4： | 1 |
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