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| 1 | Comprehensive management of full-thickness luminal defects: The next frontier of gastrointestinal endoscopy显示文摘Full thickness gastrointestinal defects such as perforations, leaks, and fistulae are a relatively common result of many of the endoscopic and surgical procedures performed in modern health care. As the number of these procedures increases, so too will the number of resultant defects. Historically, these were all treated by open surgical means with the associated morbidity and mortality. With the recent advent of advanced endoscopic techniques, these defects can be treated definitively while avoiding an open surgical procedure. Here we explore the various techniques and tools that are currently available for the treatment of gastrointestinal defects including through the scope clips, endoscopic suturing devices, over the scope clips, sealants, endoluminal stents, endoscopic suction devices, and fistula plugs. As fistulae represent the most recalcitrant of defects, we focus this editorial on a multimodal approach of treatment. This includes optimization of nutrition, treatment of infection, ablation of tracts, removal of foreign bodies, and treatment of distal obstructions. We believe that by addressing all of these factors at the time of attempted closure, the patient is optimized and has the best chance at longterm closure. However, even with all of these factors addressed, failure does occur and in those cases, endoscopic therapies may still play a role in that they allow the patient to avoid a definitive surgical therapy for a time while nutrition is optimized, and infections are addressed. | Joshua S Winder Eric M Pauli | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，8： | 13 |
| 2 | Antimicrobial peptides melittin and cecropin in- hibit replication of human immunodeficiency virus 1 by suppressing viral gene expression 显示文摘 | WACHINGER M KLEINSCHMIDT A WINDER D | 1998 | Journal of General Virology1998，79，4： | 1 |
| 3 | DNAJB6 myopathy: a vacuolar myopathy with childhood onset显示文摘 | Suarez-Cedeno G Winder T Milone M | 2014 | Muscle Nerve2014，49，： | 1 |
| 4 | Discriminative learning of local image descriptors显示文摘 | BROWN M GANG H WINDER S | 2011 | IEEE Transactions on Pattern Anal- ysis and Machine Intelligence2011，33，1： | 1 |
| 5 | On the current status of quartz crystal microbalance studies of superconductivity-dependent sliding friction显示文摘 | MASON B L WINDER S M KRIM J | 2001 | Tribology Letters2001，10，12： | 1 |
| 6 | Role of Plasma epinephrine in fasted exercising rats 显示文摘 | Terry L Winder W W Mitchell V M | 1985 | Am J Physiol Regulatory Integrative Comp Physiol1985，248，： | 1 |
| 7 | The WW domain: linking cell signalling to the membrane cytoskeleton 显示文摘 | Ilsley JL Sudol M Winder SJ | 2002 | Cell Signalling2002，14，： | 1 |
| 8 | Antimicrobial peptides melittin and cecropin inhibit replication of human immunodeficiency virus 1 by suppressing viral gene expression显示文摘 | Wachinger M kieinSchmidt A Winder D | 1998 | J Gen Virol1998，79，4： | 1 |
| 9 | Antimicrobial peptides melittin and cecropin inhibit replication of human immunodeficiency virus 1 by suppressing viral gene expression显示文摘 | Wachinger M Kleinschmidtet A Winder D | 1998 | J Gen Virol1998，79，4： | 1 |
| 10 | Serum neurone specific enolase as an indicator of stroke volume显示文摘 | CUNNINGHAM RT WATT M WINDER J | 1996 | Eur J Clin Invest1996，26，4： | 1 |
| 11 | Improving creation strategies: tracking gazelles in georgia 显示文摘 | EMIL E MALIZIA REBECCA M WINDERS | 1999 | Economic Development Review1999，16，3： | 1 |
| 12 | Antimicrobial peptides melittin and eecropin inhibit replication of human immune deficiency virus 1 by suppressing viral gene expression显示文摘 | Wachinger M Kleinschmidt A Winder D | 1998 | General Virology1998，79，4： | 1 |
| 13 | Antimacrobial peptides melittin and decropin inhibit replication of humanillimmunodificency virus by suppressing viral gene expression显示文摘 | Wachinger M Kleinschmidtet A Winder D | 1998 | J Gen Virol1998，79，4： | 1 |
| 14 | Antimicrobial peptides melittin and cecropin inhibit eplication of human immunodeficiency virus 1 by suppressing viral gene expression显示文摘 | Wachinger M Kleinschmidt A Winder D | 1998 | J GenVirol1998，79，： | 1 |
| 15 | Serum, neuron- specific enolaseas is an indicator of stroke volume 显示文摘 | Cunningham RT Watt M Winder J | 1996 | Eur J Clin Invest1996，23，4： | 1 |
| 16 | Stabilization of the nanomorphology of polymer-fullerene 'bulk hetero-j unction”blends using a novel polymerizable fullerene derivative显示文摘 | Drees M Hoppe H Winder C | | 0，，48： | 1 |
| 17 | Patterns and mechanisms of phytoplankton variability in Lake Washing- ton (USA) 显示文摘 | Arhonditsis G B Winder M Brett M T | 2004 | Water Research2004，38，： | 1 |
| 18 | Serum neuron specific enolase as a indictator of stroke volum 显示文摘 | CUNINGHAM R T WATT M WINDER J | 1996 | Eur J Clin Ivest1996，26，40： | 1 |
| 19 | The WW domain:linking cell signaling to the membrane cytoskeleton显示文摘 | Ilsley JL Sudol M Winder SJ | 2002 | Cell Signalling2002，14，3： | 1 |
| 20 | Antimicrobial peptides melittin and cecropin inhibit replication of human immunodeficiency virus by suppressing viral gene expression显示文摘 | Wachinger M Kleinschmidt A Winder D | 1998 | J Gen Virol1998，79，： | 1 |
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