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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Application of activated carbon tocyanidation 显示文摘 | Crabtree J E H Winters V W Chapman T G | 1951 | Transactions of the American Institute of Mining Metallurgical and Petroleum Engineers1951，187，： | 1 |
| 3 | Catalytic effect of biomass ash on CO,CH4 and HCN oxidation under fluidised bedcombustor conditions 显示文摘 | LOFFLER G WARGADALAM V J WINTER F | 2002 | Fuel2002，81，6： | 1 |
| 4 | Geochemical characteristics of contaminated surficial sediments in Halifax Harbour: impact of waste discharge显示文摘 | Buckley D E Winters G V | 1992 | Canadian Journal of Earth Sciences1992，29，12： | 1 |
| 5 | Catalytic effect of biomass ash on CO,CH4 and HCN oxidation under fluidised bed combustor conditions显示文摘 | LOFFLER G WARGADALAM V J WINTER F | 2002 | Fuel2002，81，6： | 1 |
| 6 | Catalytic effect of biomass ash on CO,CH4 and HCN oxidation under fluidized bed combustor conditions显示文摘 | Loffler G Wargadalam V J Winter F | 2002 | Fuel2002，81，6： | 1 |
| 7 | Accumulation of contaminant metals Scotia显示文摘 | Buckley D E Smith J N Winter G V | 1995 | Environment Geochemistry1995，10，17： | 1 |
| 8 | The influence of SO2 level and operating conditions on NOx and N2O emissions during fluidized bed combustion of coals显示文摘 | Miccio F Loffler G Wargadalam V J Winter F | 2001 | Fuel2001，，80： | 1 |
| 9 | A comparison of the physical properties of four new gener-ation flexible ureteroscopes: (de) flection, flow properties, tor-sion stiffness, and optical characteristics 显示文摘 | Paffen M L Keizer J G de Winter G V Arends A J HendrikxA J | 2008 | J Endourol2008，22，： | 1 |
| 10 | Decomposition of nitrous oxide at medium temperature显示文摘 | Loffler G Wargadalam V J Winter F | 2000 | Combustion and Flame2000，120，： | 1 |
| 11 | Ah receptorbased chemical screening bioassays:Application and limitations for the detection of Ah receptor agonists显示文摘 | Seidel S D Li V Winter G M | 2000 | Toxicological Sciences2000，55，1： | 1 |
| 12 | A chemical biology approach identifies AMPK as a modulator of melanoma oncogene MITF显示文摘 | Borgdorff V Rix U Winter G E | 2014 | Oncogene2014，33，19： | 1 |
| 13 | A comparison of the physical properties of four new gener ation flexible ureteroscopes : (de) flection, flow properties, tor- sion stiffness,and optical characteristics显示文摘 | Paffen M L Keizer J G de Winter G V Arends A J Hendrikx A J | 2008 | J Endourol2008，22，： | 1 |
| 14 | Accumulation of contaminant metals in marine sediments of Halifax Harbour, Nova Scotia: environment factors and historical trends 显示文摘 | Buckley D E Smith J N Winter G V | 1995 | Applied Geochemistry1995，10，： | 1 |
| 15 | Catalytic of biomass ash on CO,CH4 and HCN oxidation under fluidized bed combustor conditions显示文摘 | Loffler G Wargadalam V J Winter F | 2002 | Fuel2002，81，： | 1 |
| 16 | Ah receptor-based chemical screening bioassays : application and limitations for the detection of Ah receptor agonists显示文摘 | Seidel S D Li V Winter G M | 2000 | Toxicol Sci2000，55，： | 1 |
| 17 | Fat and water content of herring in Newfoundland and adjacent waters显示文摘 | HODDER V M PARSON L S WINTERS G H | | 0，，： | 1 |
| 18 | EYA4,a novel vertebrate gene related to Drosophila eyes absent显示文摘 | Borsani G DeGrandi A Ballabio A Bulfone A Bernard L Banfi S Gattuso C Mariani M Dixon M Donnai D Metcalfe K Winter R Robertson M Axton R Brown A van Heyningen V Hanson I | | 0，，： | 1 |
| 19 | Decomposition of nitrous oxide at medium temperatures显示文摘 | L(o)ffler G Wargadalam V J Winter F | | 0，，04： | 1 |
| 20 | MIMO-OFDM for Wireless Communications: Signal Detection with Enhanced Channel Estimation显示文摘 | Li V G Winter J H Sollenberger N R | 2002 | IEEE Trans on Communications2002，50，9： | 1 |
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