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| 1 | Over 100 Million Years of Enzyme Evolution Underpinning the Production of Morphine in the Papaveraceae Family of Flowering Plants显示文摘Phylogenomic analysis of whole genome sequences of five benzylisoquinoline alkaloid(BIA)-producing species from the Ranunculales and Proteales orders of flowering plants revealed the sequence and timing of evolutionary events leading to the diversification of these compounds.(S)-Reticuline is a pivotal intermediate in the synthesis of many BIAs and our analyses revealed parallel evolution between the two orders,which diverged122 million years ago(MYA).Berberine is present in species across the entire Ranunculales,and we found co-evolution of genes essential for production of the protoberberine class.The benzophenanthridine class,which includes the antimicrobial compound sanguinarine,is specific to the Papaveraceae family of Ranunculales,and biosynthetic genes emerged after the split with the Ranunculaceae family110 MYA but before the split of the three Papaveraceae species used in this study at77 MYA.The phthalideisoquinoline noscapine and morphinan class of BIAs are exclusive to the opium poppy lineage.Ks estimation of paralogous pairs indicates that morphine biosynthesis evolved more recently than 18 MYA in the Papaver genus.In the preceding 100 million years gene duplication,neofunctionalization and recruitment of additional enzyme classes,combined with gene clustering,gene fusion,and gene amplification,resulted in emergence of medicinally valuable BIAs including morphine and noscapine. | Yi Li Thilo Winzer Zhesi He Ian AGraham | 2020 | Plant Communications2020，1，2： | 3 |
| 2 | Magnesium stress corrosion cracking显示文摘The significant positive green environment influence of magnesium alloy usage in transport could be compromised by catastrophic fast fracture caused by stress corrosion cracking(SCC). Transgranular stress corrosion cracking(TGSCC) of AZ91 was evaluated using the linearly increasing stress test(LIST) and the constant extension rate test(CERT). The TGSCC threshold stress was 55-75 MPa in distilled water and in 5 g/L NaCl. The TGSCC velocity was 7×10-10-5×10-9 m/s. A delayed hydride-cracking(DHC) model for TGSCC was implemented using a finite element script in MATLAB and the model predictions were compared with experiment. A key outcome is that,during steady state TGSCC propagation,a high dynamic hydrogen concentration is expected to build up behind the crack tip. A number of recommendations are given for preventing SCC of Mg alloys in service. One of the most important recommendations might be that the total stress in service(i.e. the stress from the service loading + the fabrication stress + the residual stress) should be below a threshold level,which,in the absence of other data,could be(conservatively) estimated to be about 50% of the tensile yield strength. | N. Winzer A. Atrens W. Dietze G. Song K. U. Kainer | 2007 | 中国有色金属学会会刊:英文版2007，17，A01： | 2 |
| 3 | Plasma adiponectin,insulin sensitivity,and subclinical inflammation in women with prior gestational DM显示文摘 | Winzer C Wagner O Fwata A | 2004 | Diabetes Care2004，27，7： | 1 |
| 4 | Retinoic acid increases sodium/iodide symporter mRNA levels in human thyroid cancer cell lines and suppresses expression of functional symporter in nontransformed FRTL-Srat thyroid cells 显示文摘 | Winzer R Meissner-Weigl J | 1997 | Biochem Biophys Res Commun1997，240，： | 1 |
| 5 | Polo-like kinase isoforms in breast cancer:expression patterns and prognostic implications显示文摘 | Weichert W Kristiansen G Winzer KJ | | 0，，04： | 1 |
| 6 | Making'sense'ofmetabolism:autoinducer-2,LuxS and pathogenic bacteria显示文摘 | Vendeville A Winzer K Heurlier K | 2005 | Nat Rev Microbiol2005，3，： | 1 |
| 7 | Precise outage specifications for first-order PMD 显示文摘 | WINZER P J KOGELNIK H RAMANNAN K | 2004 | IEEE Photonic Technology Letters2004，16，2： | 1 |
| 8 | Return-to-zero modulator using a single NRZ drive signal and an optical delay interferomete,显示文摘 | WINZER P J LEUTHOLD J | 2001 | Photonics Technology Letters2001，13，12： | 1 |
| 9 | Optical phase-shift-keyed transmission显示文摘 | Gnauck A H Winzer P J | 2005 | Journal of Lightwave Technology2005，23，1： | 1 |
| 10 | Elevated expression of cyclooxygenase - 2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma显示文摘 | Denkert C Winzer KJ Muller BM | 2003 | Cancer2003，97，12： | 1 |
| 11 | CD24 expression is a new prognostic marker in breast cancer 显示文摘 | Kristiansen O Winzer KJ Majordomo E | 2003 | Clin Cancer Res2003，9，13： | 1 |
| 12 | CD24 Expression is a new prognostic marker in breast cancer显示文摘 | Glen Kristiansen Klaus2J ürgen Winzer | 2003 | Clinical Cancer Research2003，15，9： | 1 |
| 13 | Beyond 100G ethernet显示文摘 | P. J. Winzer | | 0，，07： | 1 |
| 14 | Spectrally efficient long-haul WDM transmission using 224-GB/s polarization-multiplexed 16-QAM显示文摘 | A. H. Gnauck P. J. Winzer S. Chandrasekhar X.Liu B.Zhu D.W.Peckham | | 0，，04： | 1 |
| 15 | High-speed cinematography of production blasting operations 显示文摘 | Winzer S R etal | 1979 | Mining Congress Journal1979，10，： | 1 |
| 16 | Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma显示文摘 | Denkert C Winzer KJ Muller BM | 2003 | Cancer2003，97，12： | 1 |
| 17 | Optical Phase-shift-keyed Transmission 显示文摘 | Gnauck A H Winzer P J | 2005 | Lightw Technol2005，23，1： | 1 |
| 18 | Fiber coupling efficiency for random light and its applications to lidar显示文摘 | P J Winzer W R Leeb | | 0，，： | 1 |
| 19 | Optical Phase-shift-keyed Transmission显示文摘 | GNAUCK A H WINZER P J | 2005 | J Lightwave Technol2005，23，1： | 1 |
| 20 | C-band optical 90°hybrids based on silicon on-insulator 4 ×1 waveguide couplers 显示文摘 | Zimmermann L Voigt K Winzer G | 2009 | IEEE Photon Technol Lett2009，21，3： | 1 |
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