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您的检索式：作者名="Wissam Deeb"
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| 1 | Deep brain stimulation for Tourette’s syndrome显示文摘Tourette syndrome(TS)is a childhood-onset neuropsychiatric disorder characterized by the presence of multiple motor and vocal tics.TS usually co-occurs with one or multiple psychiatric disorders.Although behavioral and pharmacological treatments for TS are available,some patients do not respond to the available treatments.For these patients,TS is a severe,chronic,and disabling disorder.In recent years,deep brain stimulation(DBS)of basal ganglia-thalamocortical networks has emerged as a promising intervention for refractory TS with or without psychiatric comorbidities.Three major challenges need to be addressed to move the field of DBS treatment for TS forward:(1)patient and DBS target selection,(2)ethical concerns with treating pediatric patients,and(3)DBS treatment optimization and improvement of individual patient outcomes(motor and phonic tics,as well as functioning and quality of life).The Tourette Association of America and the American Academy of Neurology have recently released their recommendations regarding surgical treatment for refractory TS.Here,we describe the challenges,advancements,and promises of the use of DBS in the treatment of TS.We summarize the results of clinical studies and discuss the ethical issues involved in treating pediatric patients.Our aim is to provide a better understanding of the feasibility,safety,selection process,and clinical effectiveness of DBS treatment for select cases of severe and medically intractable TS. | Wenying Xu Chencheng Zhang Wissam Deeb Bhavana Patel Yiwen Wu Valerie Voon Michael S.Okun Bomin Sun | 2020 | Translational Neurodegeneration2020，9，1： | 1 |
| 2 | Benign tremulous Parkinsonism:a unique entity or another facet of Parkinson’s disease?显示文摘Benign tremulous parkinsonism(BTP)is characterized by a prominent tremor that occurs both at rest and with action in conjunction with other mild features of parkinsonism.The progression of symptoms is typically slow and there is often a positive family history.Although BTP is included within the phenotypic spectrum of Parkinsonism its exact relationship with idiopathic Parkinson’s disease remains unclear.Treatment of BTP is challenging especially considering the poor response to levodopa,therefore surgical therapies such as deep brain stimulation surgery are sought for treatment of these tremors.In this review,we will summarize the clinical features,diagnosis,neuropathology and treatment for BTP. | Wissam Deeb Wei Hu Leonardo Almeida Addie Patterson Daniel Martinez-Ramirez Aparna Wagle Shukla | 2016 | Translational Neurodegeneration2016，5，1： | 0 |
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