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| 1 | Laparoscopic natural orifice specimen extraction-colectomy: A systematic review显示文摘Over the last 20 years, laparoscopic colorectal surgery has shown equal efficacy for benign and malignant colorectal diseases when compared to open surgery. However, a laparoscopic approach reduces postoperative morbidity and shortens hospital stay. In the quest to optimize outcomes after laparoscopic colorectal surgery, reduction of access trauma could be a way to improve recovery. To date, one method to reduce access trauma is natural orifice specimen extraction(NOSE). NOSE aims to reduce access trauma in laparoscopic colorectal surgery. The specimen is delivered via a natural orifice and the anastomosis is created intracorporeally. Different methods are used to extract the specimen and to create a bowel anastomosis. Currently, specimens are delivered transcolonically, transrectally, transanally, or transvaginally. Each of these NOSEprocedures raises specific issues with regard to operative technique and application. The presumed benefits of NOSE-procedures are less pain, lower analgesia requirements, faster recovery, shorter hospital stay, better cosmetic results, and lower incisional hernia rates. Avoidance of extraction site laparotomy is the most important characteristic of NOSE. Concerns associated with the NOSE-technique include bacterial contamination of the peritoneal cavity, inflammatory response, and postoperative outcomes, including postoperative pain and the functional and oncologic outcomes. These issues need to be studied in prospective randomized controlled trials. The aim of this systematic review is to describe the role of NOSE in minimally invasive colorectal surgery. | Albert M Wolthuis Anthony de Buck van Overstraeten André D'Hoore | 2014 | World Journal of Gastroenterology2014，20，36： | 65 |
| 2 | Transanal total mesorectal excision:Towards standardization of technique显示文摘AIM: To describe the role of Transanal total mesorectal excision(Ta TME) in minimally invasive rectal cancer surgery, to examine the differences in patient selection and in reported surgical techniques and their impactson postoperative outcomes and to discuss the future of Ta TME. METHODS: MEDLINE(Pub Med), EMBASE, and The Cochrane Library were systematically searched through the 1st of March 2015 using a predefined search strategy. RESULTS: A total of 20 studies with 323 patients were included. Most studies were single-arm prospective studies with fewer than 100 patients. Multiple transanal access platforms were used, and the laparoscopic approach was either multi- or single port. The procedure was initiated transanally or transabdominally. If a simultaneous approach with 2 operating surgeons was chosen, the operative time was significantly reduced. CONCLUSION: Ta TME was also associated with better TME specimens and a longer distal resection margin. Ta TME is thus feasible in expert hands, but the learning curve and safety profile are not well defined. Longterm follow-up regarding anal function and oncological outcomes should be performed in the future. | Albert M Wolthuis Gabriele Bislenghi Anthony de Buck van Overstraeten André D'Hoore | 2015 | World Journal of Gastroenterology2015，21，44： | 9 |
| 3 | Surgery for Crohn's disease in the era of biologicals:A reduced need or delayed verdict?显示文摘Crohn's disease(CD) is a chronic inflammatory bowel disease that can affect the entire gastrointestinal tract.Ultimately,up to 70% of all patients will need surgery,despite optimized medical therapy.Moreover,about half of the patients will need redo-surgery because of disease recurrence.The introduction of anti-tumor necrosis factor(TNF) drugs(Infliximab in 1998) revolutionized the treatment of CD.Different randomized trials assessed the efficacy of anti-TNF treatment not only to induce,but also to maintain,steroid-free remission.Furthermore,these agents can rapidly lead to mucosal healing.This aspect is important,as it is a major predictor for long-term disease control.Subgroup analyses of responding patients seemed to suggest a reduction in the need for surgery at median-term follow up(1-3 years).However if one looks at population surveys,one does not observe any decline in the need for surgery since the introduction of Infliximab in 1998.The short follow-up term and the exclusion of patients with imminent surgical need in the randomized trials could bias the results.Only 60% of patients respond to induction of anti-TNF therapy,moreover,some patients will actually develop resistance to biologicals.Many patients are diagnosed when stenosing disease has already occurred,obviating the need for biological therapy.In a further attempt to change the actual course of the disease,top down strategies have been progressively implemented.Whether this will indeed obviate surgery for a substantial group of patients remains unclear.For the time being,surgery will still play a pivotal role in the treatment of CD. | Anthony de Buck van Overstraeten Albert Wolthuis André D'Hoore | 2012 | World Journal of Gastroenterology2012，18，29： | 4 |
| 4 | The use of Oxaliplatin or Mitomycin C in HIPEC treatment for peritoneal carcinomatosis from colorectal cancer: A comparative study显示文摘 | D. Hompes A. D’Hoore A. Wolthuis S. Fieuws B. Mirck S. Bruin V. Verwaal | 2014 | J. Surg. Oncol2014，，： | 2 |
| 5 | AirSeal system insufflator to maintain a stable pneumorectum during TAMIS显示文摘 | G. Bislenghi A. M. Wolthuis A. Buck van Overstraeten A. D’Hoore | 2015 | Techniques in Coloproctology2015，，1： | 2 |
| 6 | Peritoneal fluid cytokines and matrix metalloproteinases as early markers of anastomotic leakage in colorectal anastomosis: a literature review and meta‐analysis显示文摘 | C. Cini A. Wolthuis A. D’Hoore | 2013 | Colorectal Dis2013，，9： | 2 |
| 7 | Complex iliac and bilateral common femoral artery aneurysms:a novel hybrid procedure显示文摘 | Wolthuis AM Watkinson AF Kinsella DC | 2006 | Surgeon2006，4，2： | 1 |
| 8 | Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice显示文摘 | Wolthuis EK Vlaar AP Choi G | | 0，，： | 1 |
| 9 | Plasminogen activator inhibitor-type I gene deficient mice show reduced influx of neu-trophils in ventilator-induced lung injury 显示文摘 | Wolthuis EK Vlaar AP Hofstm JJ | 2011 | Crit Care Res Pract2011，12，21： | 1 |
| 10 | Mechanical ventila- tion with lower tidal volumes and positive end-expiratory pres- sure prevents pulmonary inflammation in pations without pre- existing lung injury 显示文摘 | Wolthuis EK Choi G Dessing MC | 2008 | Anesthesiology2008，108，： | 1 |
| 11 | Impaet of interval between neoadjuvant chemoradiotherapy and TME for locally advanced rectal cancer on pathologic response and oncologic outcome显示文摘 | Wolthuis A M Penninckx F Haustermans K | 2012 | Ann Surg Oncol2012，19，9： | 1 |
| 12 | Cell density modulates growth, ECM and protein synthesis of cultured rat MsC显示文摘 | Wolthuis A Roberts AB Schnaper HW | 1993 | Am J Pathol1993，143，4： | 1 |
| 13 | Mechanical ventilation aggravates trans{usion-related acute lung injury induced by MHC-I class antibodies 显示文摘 | Vlaar A P Wolthuis E K Hofstra J J | 2010 | Intensive Care Med2010，36，5： | 1 |
| 14 | To cell cycle, swing the APC/C显示文摘 | van Leuken R Clijsters L Wolthuis R | 2008 | Biochim Biophys Acta2008，1786，： | 1 |
| 15 | Laparoscopic low anterior resection and transanal pull-through for low rectal cancer:a Natural Orifice Specimen Extraction (NOSE) technique显示文摘 | D'Hoore A Wolthuis AM | | 0，，7： | 1 |
| 16 | Mechanical ventilation aggravates transfusion-related acute lung injury induced by MHC-I class antibodies显示文摘 | Vlaar AP Wolthuis EK Hofstra J J | 2010 | Intensive Care Med2010，36，5： | 1 |
| 17 | Mechanical ventilation withlower tidal volumes and positive end-expiratory pressure prevents pul-monary inflammation in patients without preexisting lung injury 显示文摘 | Wolthuis EK Choi G Dessing MC | 2008 | Anesthesiology2008，108，1： | 1 |
| 18 | Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice显示文摘 | Wolthuis EK Vlaar AP Choi G | 2012 | Crit Care Res Pract2012，2012，13： | 1 |
| 19 | Laparoscopic low anterior re- section and transanal pull-through for low rectal cancer: a Natural Orifice Specimen Extraction (NOSE) technique显示文摘 | D'Hoore A Wolthuis AM | 2011 | Coloreetal Dis2011，13，7： | 1 |
| 20 | Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury显示文摘 | WOLTHUIS E K CHOI G DESSING M C | 2008 | Anesthesiology2008，108，1： | 1 |
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