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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Firsthand cigarette smoke alters fibroblast migration and survival: implications for impaired healing 显示文摘 | Wong LS Martins-Green M | 2004 | Wound Repair Regen2004，12，： | 1 |
| 3 | Aberrant production of soluble costimulatory molecules CTLA-4,CD28,CD80 and CD86 in patients with systemic lupus erythematosus显示文摘 | Wong CK Lit LCW Tam LS | 2005 | Rheumatol2005，44，： | 1 |
| 4 | Raised plasma concen-tration and ex vivo production of inflammatory chemokinesin patients with systemic lupus erythematosus 显示文摘 | Lit Lc Wong CK Tam LS | 2006 | AnnRheum Dis2006，65，2： | 1 |
| 5 | An epididymis-specific beta-defensin is important for the initiation of sperm maturation显示文摘 | Zhou CX Zhang YL Xiao L Zheng M Leung KM Chan MY Lo PS Tsang LL Wong HY Ho LS | | 0，，05： | 1 |
| 6 | CXCL 9 and CXCL 10 as Sensitive markers of disease activity in patients with rheumatoid arthritis显示文摘 | Kuan WP Tam LS Wong CK | 2010 | J Rheumatol2010，37，2： | 1 |
| 7 | Comparison ofUSC0M ultrasonic cardiac output monitor with pulmo-mary artery catheter thermodilution in patients undergoingliver transplantation 显示文摘 | Wong LS Yong BH Young KK | 2008 | Liver Transpl2008，14，7： | 1 |
| 8 | Activation profile of TolMike receptors of peripheral blood lymphocytes in patients with systemic lupus erythematosus显示文摘 | Wong CK Wong PTY Tam LS | 2010 | Clin Exp Immunol2010，159，1： | 1 |
| 9 | Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus:Implications for Th17-mediated inflammation in autoimmunity显示文摘 | Wong CK Wan Lit LC Tam LS | 2008 | Clinical Immunology2008，127，3： | 1 |
| 10 | Nonlinear Dynamics in Real-Time Equity Market Indices: evidence from the United Kingdom显示文摘 | Abhyankar A Copeland LS Wong WK | 1995 | Economic Journal1995，105，7： | 1 |
| 11 | Detection of circulating tumor cells and nodal metastasis by reverse transcriptase-polymerase chain reaction technique显示文摘 | Wong LS Cantrill JE Odogwu S | 1997 | Br J Surg1997，84，6： | 1 |
| 12 | Decreased ex vivo production of TNF- alpha and IL-8 by peripheral blood cells of patients with rheumatoid ar- thritis after infliximab therapy 显示文摘 | Lun SW Wong CK Tam LS | 2007 | Int Immunopharmacol2007，7，13： | 1 |
| 13 | Quantitative analysis of retinal vessel attenuation in eyes with retinitis pigmentosa显示文摘 | Ma Y Kawasaki R Dobson LP Ruddle JB Kearns LS Wong TY | | 0，，7： | 1 |
| 14 | Elevated production of B cell chemokine CXCL 13 is correlated with systemic lupus erythematosus disease activity显示文摘 | Wong CK Wong PT Tam LS | 2010 | J Clin Immunol2010，30，1： | 1 |
| 15 | Hyperproduetion of IL - 23 and IL -17 in patients with systemic lupus erythematosus: implications for Thl7- mediated inflammation in autoimmunity 显示文摘 | Wong CK Lit LC Tam LS | 2008 | Clin Immunol2008，127，3： | 1 |
| 16 | Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus:implications for Th17-mediated inflammation in auto-immunity显示文摘 | Wong CK Lit LC Tam LS Li EK Wong PT Lam CW | 2008 | Clin Immunol2008，127，3： | 1 |
| 17 | Hyperproduetion of IL-23 and IL-17 in patients with systemic lupus erythematosus:Implications for Thl7-mediated inflammation in auto-immunity显示文摘 | Wong CK Lit LC Tam LS | | 0，，03： | 1 |
| 18 | Safety and efficacy of leflunomide in the treatment of lupus nephritis refractory or intolerant to traditional immunosuppressive therapy : an open label trial 显示文摘 | Tam LS Li EK Wong CK | 2006 | Ann Rheum Dis2006，65，3： | 1 |
| 19 | ERCC1, hRad51, and BRCA1 protein expression in relation to tumour response and survival of stage Ⅲ/Ⅳ NSCLC patients treated with chemotherapy显示文摘 | Wachters FM Wong LS Timens W | 2005 | Lung Cancer2005，50，2： | 1 |
| 20 | Safety and efficacy of leflunomide in the treatment of lupus nephritis refractory or intolerant to traditional immunosuppressive therapy: an open label trial 显示文摘 | Tam LS Li EK Wong CK | 2006 | Ann Rheum Dis2006，65，3： | 1 |
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