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| 1 | Characteristics, Management, and Outcomes of Acute Heart Failure in the Emergency Department: A Multicenter Registry Study with 1-year Follow-up in a Chinese Cohort in Beijing显示文摘 | Guo-Gan Wang Si-Jia Wang Jian Qin Chun-Sheng Li Xue-Zhong Yu Hong Shen Li-Pei Yang Yan Fu Ya-An Zheng Bin Zhao Dong-Min Yu Fu-Jun Qin De-Gui Zhou Ying Li Fu-Jun Liu Wei Li Wei Zhao Xin Gao Zheng Wang Ming Jin Hong Zeng Yi Li Guo-Xing Wang Hong Zhou Xiao-Lu Sun Peng-Bo Wang Kam-Sang Woo | 2017 | Chinese Medical Journal2017，，16： | 21 |
| 2 | Retrospective analysis of extra-gastrointestinal stromal tumors显示文摘AIM:To investigate the clinicopathologic features of patients with extra-gastrointestinal stromal tumors(EGISTs)in South Korea.METHODS:A total of 51 patients with an EGIST were identified.The clinicopathologic features,including sex,age,location,tumor size,histology,mitotic rate,immunohistochemical features,genetic status and survival data,were analyzed.RESULTS:The median age was 55 years(range:29-80years),and male:female ratio was 1:1.04.The most common site was in the mesentery(n=15)followed by the retroperitoneum(n=13)and omentum(n=8).The median tumor size was 9.0 cm(range:2.6-30.0cm)and the median mitotic rate was 5.0/50HPF.(1/50-185/50).KIT was analyzed in 16,which revealed 10cases with wild-type KIT and 6 cases with an exon 11mutation.Among 51 patients,31 patients had undergone surgery,and 10 had unresectable disease and had taken palliative imatinib,which resulted in 22.7 mo of progression-free survival.Of the patients who had undergone surgery,18 did not take adjuvant imatinib,and 8 of these were categorized as'high risk'according to the risk criteria.However,the relapse-free survival was not different(P=0.157)between two groups.CONCLUSION:Because the biologic behaviors of GISTs differ according to the location of the tumor,a more stratified strategy is required for managing EGISTs including incorporation of molecular features. | Jun Ho Yi Byeong-Bae Park Jung Hun Kang In Gyu Hwang Dong Bok Shin Sun Jin Sym Hee Kyung Ahn Soon Il Lee Do Hyoung Lim Keon Woo Park Young-Woong Won Sung Hee Lim Se Hoon Park | 2015 | World Journal of Gastroenterology2015，21，6： | 9 |
| 3 | Disease Progression, Response to ACEI/ATRA Therapy and Influence of ACE Gene in IgA Nephritis显示文摘Various studies have shown that angiotensin-converting enzyme (ACE) gene insertion/deletion (ID) polymorphism may play a role in the progression to end stage renal failure (ESRF) in patients with IgA nephritis (IgAN). In this randomized controlled trial, patients were followed up for 5 years to determine their long-term renal outcome to ACEI/ATRA therapy and to ascertain if their ACE gene profile could play a role in determining their response to therapy. Seventy-five patients with IgAN were enlisted. Thirty-seven were on ACEI/ATRA therapy for 62 ± 5 months and thirty-eight were untreated and served as controls. All patients had their ACE gene ID polymorphism genotyped. Compared to controls, treated patients had lower serum creatinine (p < 0.001), lower proteinuria (p < 0.002) and fewer numbers progressing to ESRF (p < 0.002). Among patients with genotype II, there were less ESRF in the treatment group when compared to the untreated control group (p < 0.02). The advantage of therapy was not seen in patients with ID or DD genotypes. ACEI/ATRA therapy was found to be effective in retarding disease progression in IgAN with years to ESRF significantly extended in patients at all levels of renal function, including patients whose outcome were ESRF. Genotyping showed better response to therapy only for those with genotype II. The common mechanism is probably through lower levels of ACE, glomerular pressure and proteinuria resulting in reduced renal damage and retardation of progression to ESRF. | Keng-Thye Woo Yeow-Kok Lau Yi Zhao Fang-E Liu Hwee-Boon Tan Eng-Keng Tan Fook-Chong Stephanie Choong-Meng Chan Kok-Seng Wong | 2007 | Cellular & Molecular Immunology2007，4，3： | 7 |
| 4 | Endoscopic submucosal dissection for early gastric cancer with undifferentiated histology: could we extend the criteria beyond?显示文摘 | Yi Young Kim Seong Woo Jeon JiYeon Kim Jung Chul Park Kwang Bum Cho Kyung Sik Park EunSoo Kim Yun Jin Chung Joong Goo Kwon Jin Tae Jung Eun Young Kim Kyeong Ok Kim ByungIk Jang Si Hyung Lee Chang Hun Yang | 2013 | Surgical Endoscopy2013，，12： | 3 |
| 5 | Immune enhancement effect of an herb complex extract through the activation of natural killer cells and the regulation of cytokine levels in a cyclophosphamide-induced immunosuppression rat model显示文摘Objective: To investigate the effects of a herb complex extract(HCE) prepared from Cornus officinalis Sieb. Et Zucc., Eriobotrya japonica Lindley, and olive leaves on immune response of mouse spleen NK cells in vitro and in vivo analysis. Methods: The activity of natural killer(NK) cells was measured in splenocytes and YAC-1 cells. Mice were immunosuppressed using cyclophosphamide(5 mg/kg body weight). Three different doses of HCE(200, 400, and 800 mg/kg body weight) and red ginseng extract(800 mg/kg body weight) which was used as standard immunomodulatory herb were administered orally for 4 weeks. The body weight, dietary, water intake, organs(liver, thymus, and spleen) weight, completed blood count, and cytokines(tumor necrosis factor alpha, interferon gamma, and interleukin-2) production was measured. Results: At the maximum concentration of HCE, the activity of NK cells was increased by 48.5%. HCE increased liver, spleen, and thymus weights without altering numbers of white blood cells, lymphocytes, and neutrophils in a cyclophosphamide-induced immunosuppression rat model. However, HCE recovered the inhibited cytokine expression; HCE(800 mg/kg) increased cytokines levels. The results indicate the immune enhancement potential of this HCE. Conclusion: The HCE enhances immunity by increasing NK cell activity, regulating cytokine levels, and maintaining spleen weight. Therefore, it may be used as a potential immunity enhancer. | Sung Min Woo Woo Rin Choi Dooly Jang Chun Sik Yi Hae Lim Kim Kyung Hyeon Kim Jong Tae Kim Won Hee Choi Seung Hee Jang Min Jeung Kim Ji Hyang Wee Yeon Ki Kim Bao Le | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，12： | 2 |
| 6 | Place-and Age-Responsive Disaster Risk Reduction for Hong Kong:Collaborative Place Audit and Social Vulnerability Index for Elders显示文摘This study reformulates the concept and contents of disaster risk reduction(DRR) in Hong Kong through an explorative study on collaborative place audit(CPA) and social vulnerability index(SVI) for elders.We believe that DRR should be place-and age-responsive.Accordingly,DRR needs to go beyond technical concerns and address vulnerability and risk encountered in the built environment where an individual is located.A place-centered DRR begins with an assessment of person–environment relations from an interdependent perspective.Community becomes a significant scale at which to address vulnerability and risks across a range of environmental,socioeconomic,and institutional factors.A CPA is a ground-level assessment tool that identifies vulnerability and risk in the built and social environment.The audit encourages collaboration in problem solving that uses social capital to effect decisionmaking change in hierarchies and policy networks.Ageresponsive DRR facilitates distinguishing living-alone elders from the general population.This perspective addresses varying degrees of vulnerability due to social and communicational isolation,poverty,disability,being sent to hospital and/or receiving institutional care,as well as lack of access to primary care.Accordingly,SVI,based oncompound indicators,is developed to assess the differentiation of vulnerability across the territory with particular reference to the elders.These two approaches,namely,CPA and SVI,build community capacity to develop a resilient city,as well as to provide evidence-based recommendations that improve government-led disaster preparedness and contingency plans. | Yi Sun Pui Hing Chau Moses Wong Jean Woo | 2017 | International Journal of Disaster Risk Science2017，8，2： | 2 |
| 7 | Heteroatom substitution-induced asymmetric A–D–A type non-fullerene acceptor for efficient organic solar cells显示文摘Research on asymmetric A–D–A structured non-fullerene acceptors has lagged far behind the development of symmetric counterpart.In this contribution,by simply replacing one sulfur atom in indacenodithiophene unit with a selenium atom,an asymmetric building block Se PT and a corresponding asymmetric non-fullerene acceptor Se PT-IN have been developed.Asymmetric Se PT-IN achieved a high efficiency of 10.20% in organic solar cells when blended with PBT1-C,much higher than that of symmetric TPT-IN counterpart(8.91%).Our results demonstrated an effective heteroatom substitution strategy to develop asymmetric A–D–A structured non-fullerene acceptors. | Chao Lia Jiali Song Yunhao Cai Guangchao Han Wenyu Zheng Yuanping Yi Hwa Sook Ryu Han Young Woo Yanming Sun | 2020 | Journal of Energy Chemistry2020，29，1： | 2 |
| 8 | Feasibility of Single-Beat Full-Volume Capture Real-Time Three-Dimensional Echocardiography and Auto-Contouring Algorithm for Quantification of Left Ventricular Volume: Validation with Cardiac Magnetic Resonance Imaging显示文摘 | Sung-A Chang Sang-Chol Lee Eun-Young Kim Seung-Hee Hahm Shin Yi Jang Sung-Ji Park Jin-Oh Choi Seung Woo Park Yeon Hyeon Choe Jae K. Oh | 2011 | Journal of the American Society of Echocardiography2011，，8： | 2 |
| 9 | Weekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell carcinoma显示文摘AIM: To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate(FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma(SCC).METHODS: A multi-center, open-label, prospective phase Ⅱ study was designed.Thirty-three esophageal SCC patients with documented progression after fluoropyrimidine/platinum-based first-line chemotherapy were enrolled and treated with docetaxel 35 mg/m2 and gemcitabine 1000 mg/m2 iv at a FDR(10 mg/m2 per minute) on days 1 and 8.Treatment was repeatedevery twenty-one days until disease progression, unacceptable toxicity, or consent withdrawal.The primary endpoint was response rate(RR), and secondary endpoints were safety, progression-free survival(PFS) and overall survival(OS).RESULTS: Combination of weekly docetaxel and FDR gemcitabine was well tolerated: the most common treatment-related adverse events were anemia(97%), fatigue(64%) and neutropenia(55%).One patient with multiple lung and lymph node metastases died of respiratory failure after receiving four cycles of chemotherapy, and the possibility of drug-induced pneumonitis could not be completely excluded.Disease control(objective response plus stable disease) in the ITT population was achieved in 88% of patients, and the overall RR was 30%(95%CI: 15%-46%).The median PFS and OS were 4.0(95%CI: 3.4-4.6) and 8.8 mo(95%CI: 7.8-9.8 mo), respectively.CONCLUSION: A combination of weekly docetaxel and FDR gemcitabine showed promising antitumor activity and tolerability in previously treated, metastatic esophageal SCC. | Min-Young Lee Ki Sun Jung Hae Su Kim Ji Yun Lee Sung Hee Lim Moonjin Kim Hyun Ae Jung Sung Min Kim Jong Mu Sun Myung-Ju Ahn Jeeyun Lee Se Hoon Park Seong Yoon Yi In Gyu Hwang Sang-Cheol Lee Hee Kyung Ahn Do Hyoung Lim Soon Il Lee Keon Woo Park | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 10 | Optimum design for lin- earity and efficiency of a microwave Doherty amplifier u- sing a new load matching technique 显示文摘 | Yang Y Yi J Woo Y Y | 2001 | Microwave Journal2001，44，： | 1 |
| 11 | Ice-nucleation protein gene cloning from Pseudomonas syingae显示文摘 | HONG C B YI H J WOO J K | 1990 | Korean Biochemical Jour- nal1990，23，1： | 1 |
| 12 | Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women显示文摘 | Young Joo Jeon Yi Seul Choi HyungChul Rah Su Yeoun Kim Dong Hee Choi Sun Hee Cha Ji Eun Shin Sung Han Shim Woo Sik Lee Nam Keun Kim | 2011 | Gene2011，，2： | 1 |
| 13 | Hyperhomocysteinemia is a risk factor for arterial endothelial dysfunction in humans显示文摘 | Chook P Lolin YI | 1997 | Circulation1997，96，： | 1 |
| 14 | Hyperhomocysteinemia is a risk factor for arterial endothelial dysfunction in humans显示文摘 | Woo KS Chook P Lolin YI | 1997 | Circulation1997，96，8： | 1 |
| 15 | Hyperhomocysteinemia is a risk factor for arterial endothelial dysfunction in humans 显示文摘 | Chook P Lolin YI | 1997 | Circulation1997，96，： | 1 |
| 16 | Folic acid improves arterial endotheli- al function in adults with hyperhomocystiiaemia显示文摘 | Woo KS Chook P Lolin YI | 1999 | J Am Coil Cardiol1999，34，7： | 1 |
| 17 | Post-transcriptional suppression of proto-oncogene c-fins expression by Vigi- lin in breast cancer 显示文摘 | Woo H H Yi X Lamb T | 2011 | Molecular and Cellular Biology2011，31，1： | 1 |
| 18 | Feedforward amplifier for WCDMA base stations with a new adaptive control method 显示文摘 | Woo Y Y Yang Y Yi J | 2002 | EEE MTT-S International Microwave Symposium Digest2002，2，： | 1 |
| 19 | Platelet Transfusion can be Related to Liver Regeneration After Living Donor Liver Transplantation显示文摘 | Joohyun Kim Nam-Joon Yi Woo Young Shin Taehoon Kim Kuhn Uk Lee Kyung-Suk Suh | 2010 | World Journal of Surgery2010，，5： | 1 |
| 20 | Msx2 mediates the inhibitory action of TNF-alpha on osteoblast differentiation显示文摘 | Lee HL Yi T Woo KM | 2010 | Exp Mol Med2010，42，6： | 1 |
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