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| 1 | 代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点(英文)显示文摘Objective Metabotropic glutamate receptors(mG luR)are predominantly involved in maintenance of cellular homeostasis of central nervous system.However,evidences have suggested other roles of mG luR in human tumors.Aberrant mG luR signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain tumors.This review intends to summarize recent findings regarding the involvement of mG luR-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GBM),highlighting the potential therapeutic applications of mG luR ligands.In addition to the growing number of studies reporting mG luR gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG luR1 and mG luR3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K pathways.In addition,mG luR3 antagonists promoted astroglial differentiation of GBM cells and also enabled cytotoxic action of temozolomide(TMZ).mG luR3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κB.Further,continuous pharmacological blockade of mG luR1 and mG luR3 have been shown to reduced growth of GBM tumor in two independent in vivo xenograft models.In parallel,low levels of mG luR3 mRNA in GBM resections may be a predictor for long survival rate of patients.Since several Phase I,II and III clinical trials are being performed using group I and II mG luR modulators,there is a strong scientifically-based rationale for testing mG luR antagonists as an adjuvant therapy for malignant brain tumors. | Pereira MS Klamt F Thomé CC Worm PV de Oliveira DL | 2017 | 中华神经外科疾病研究杂志2017，16，1： | 3 |
| 2 | Chronic brain hypoperfu- sion causes early glial activation and neuronal death, and subsequent long-term memory impairment 显示文摘 | Cechetti F Pagnussat AS Worm PV | 2012 | Brain Res Bull2012，87，1： | 1 |
| 3 | Chronic brain hypoperfu- sion causes early glial activation and neuronal death, and subsequent long-term memory impairment 显示文摘 | Cechetti F Pagnussat AS Worm PV | 2012 | Brain Res Bull2012，87，1： | 1 |
| 4 | The modified 2VO ischemia protocol causes cognitive impairment similar to that induced by the standard method, but with a better survival rate显示文摘 | Cechetti F Worm PV Pereira LO | 2010 | Braz J Med Biol Res2010，43，12： | 1 |
| 5 | Chronic brain hypoper-fusion causes early glial activation and neuronal death, and subsequent long-term memory impairment 显示文摘 | Cechetti F Pagnussat AS Worm PV | 2012 | Brain Res Bull2012，87，： | 1 |
| 6 | Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment 显示文摘 | CECHETTI F PAGNUSSAT AS WORM PV | 2012 | Brain Res Bull2012，87，1： | 1 |
| 7 | Quantitative computed tomography and cranial burr holes: a model to evaluate the quality of cranial reconstruction in humans 显示文摘 | Worm PV Ferreira NP Ferreira MP | 2012 | J Craniofac Surg2012，23，： | 1 |
| 8 | The modified 2VO ischemia protocol causes cognitive impairment similar to that induced by the standard method,but with a better survival rate显示文摘 | Cechetti F Worm PV Pereira LO | 2010 | Braz J Med Biol Res2010，43，12： | 1 |
| 9 | Environmental enrichment prevents behavioral deficits and oxidative stress caused by chronic cerebral hypoperfusion in the rat 显示文摘 | Ceehetti F Worm PV Lovatel G | 2012 | Life Sci2012，91，12： | 1 |
| 10 | Forced treadmill exer- cise prevents oxidative stress and memory deficits following chronic cerebral hypoperfusion in the rat 显示文摘 | Cechetti F Worm PV Eisner VR | 2012 | Neurobiol Learn Mem2012，97，1： | 1 |
| 11 | The modified 2VO isehemia protocol causes cognitive impairment similar to that induced by the standard method,but with a better survival rate 显示文摘 | Cechetti F Worm PV Pereira LO | 2010 | BrazJ Med BiolRes2010，43，12： | 1 |
| 12 | The modified 2VO is- chemia protocol causes cognitive impairment similar to that in- duced by the standard method, but with a better survival rate 显示文摘 | Cechetti F Worm PV Pereira LO et ol | 2010 | Braz J Med Biol Res2010，43，12： | 1 |
| 13 | Chronic brain hypoperfusion causes early glial activation and neuronal death,and subsequent long-term memory impairment显示文摘 | Cechetti F Pagnussat AS Worm PV | | 0，，01： | 1 |
| 14 | Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment显示文摘 | Cechetti F Pagnussat AS Worm PV | 2012 | Brain Res Bull2012，87，： | 1 |
| 15 | The modified 2VO is- chemia protocol causes cognitive impairment similar to that in- duced by the standard method, but with a better survival rate 显示文摘 | Cechetti F Worm PV Pereira LO etal | 2010 | Braz J Med Biol Res2010，43，12： | 1 |
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