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| 1 | Can non-invasive measurements aid clinical assessment of volume in patients with cirrhosis?显示文摘AIM:To evaluate the non-invasive assessments of volume status in patients with cirrhosis.METHODS:Echocardiography and multifrequency bioimpedance analysis measurements and short synacthen tests were made in 20 stable and 25 acutely decompensated patients with cirrhosis.RESULTS:Both groups had similar clinical assessments,cortisol response and total body water(TBW),however the ratio of extracellular water(ECW)/TBW was significantly greater in the trunk(0.420±0.004 vs0.404±0.005),and limbs(R leg 0.41±0.003 vs 0.398±0.003,P<0.05,and L leg 0.412±0.003 vs 0.399±0.003)with decompensated cirrhosis compared to stable cirrhotics,P<0.05).Echocardiogram derived right atrial and ventricular filling and end diastolic pressures and presence of increased left ventricular end diastolic volume and diastolic dysfunction were similar in both groups.The decompensated group had lower systemic blood pressure,mean systolic 101.8±4.3 vs122.4±5.3 and diastolic 58.4±4.1 mmHg vs 68.8±3.1 mmHg respectively,P<0.01,and serum albumin30(27-33)vs 32(31-40.5)g/L,P<0.01.CONCLUSION:Decompensated cirrhotics had greater leg and truncal ECW expansion with lower serum albumin levels consistent with intravascular volume depletion and increased vascular permeability. | Andrew Davenport Banwari Argawal Gavin Wright Konstantinos Mantzoukis Rumyana Dimitrova Joseph Davar Panayota Vasianopoulou Andrew K Burroughs | 2013 | World Journal of Hepatology2013，5，8： | 3 |
| 2 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 3 | 伦理学与SARS:多伦多的教训显示文摘SARS的流行说明传染病在世界范围内流行是件多么容易的事,为了更好地应对下一次流行病,我们不仅要解决医学方面的问题,也同样需要解决伦理学方面的问题。 | Peter A Singer Solomon R Benatar Mark Bernstein Abdallah S Daar Bernard M Dickens Susan K MacRae Ross E G Upshur Linda Wright Randi Zlotnik Shaul 肖月 | 2004 | 英国医学杂志中文版2004，7，4： | 3 |
| 4 | Meeting report:a hard look at the state of enamel research显示文摘The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines(ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research(NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3 D cell culture/organoids. Scientists from a number of disciplines,representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. | ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer | 2017 | International Journal of Oral Science2017，9，4： | 3 |
| 5 | Dynamic motor tests from synchronously sampled waveform显示文摘 | Wright F Zick K E | 1986 | IEEE Trans on LA1986，22，3： | 2 |
| 6 | Plastic phenotypic response to light of 16 congeneric shrubs from a panamanian rainforest显示文摘 | Valladares F Wright S J Lasso E Kitajima K Pearcy R W | 2000 | Ecology2000，81，： | 2 |
| 7 | Ureteroscopy and stones:Current status and future expectations显示文摘Urolithaisis is becoming an ever increasing urological,nephrological and primary care problem.With a lifetime prevalence approaching 10% and increasing morbidity due to stone disease,the role of ureteroscopy and stone removal is becoming more important.We discuss the current status of stone disease and review the ever increasing role that ureteroscopy has to play in its management.We discuss technological advances that have been made in stone management and give you an overview of when,how and why ureteroscopy is the most common treatment option for stone management.We touch on the role of robotic ureteroscopy and the future of ureteroscopy in the next 10 years. | Anna E Wright Nicholas J Rukin Bhaskar K Somani | 2014 | World Journal of Nephrology2014，3，4： | 2 |
| 8 | Reduced risks of death and CHF are associated with statin therapy administered acutely within the first 24 h of AMI显示文摘 | Wright RS Bybee K Miller WL | 2006 | Int J Cardiol2006，108，3： | 1 |
| 9 | Novel 1xN and NxN Integrated Optical Switches Using Self-lmaging Multimode GaAs/Al-GaAs Waveguides显示文摘 | Jenkins R M Heaton J M Wright D R Parker J T Birbeck J C H Smith G W Hilton K P | 1994 | Appl Phys Lett 71994，64，： | 1 |
| 10 | Efficacy of topical silver against fungal burn wound pathogens显示文摘 | Lam K Hansen D | 1999 | Am J Infect Control1999，27，4： | 1 |
| 11 | Integrated adrenal,somatotropic, and immune responses of growing pigs to treatment with lipopolysaccharide 显示文摘 | Balaji R Hill C M | 2000 | J Amm Sci2000，78，： | 1 |
| 12 | The treatment of earlymorning awakening insomnia with 2 evenings of bright light显示文摘 | Lack L Wright H Kemp K | 2005 | Sleep2005，28，5： | 1 |
| 13 | Preadipocyte recruitment in stromal vascular cultures after depletion of committed preadipocytes by immunocytotoxicity显示文摘 | YU Z K WRIGHT J T HAUSMAN G J | 1997 | Obesity Res1997，5，1： | 1 |
| 14 | Self-Esteem Levels and Cardiovascular and Inflammatory Respon- ses to Acute Stress显示文摘 | O'DONNELL K BRYDON L WRIGHT C E | 2008 | Brain Behavior and Immmunity2008，22，： | 1 |
| 15 | Corporate Governance and Market Valuation of Capital and RD Investments显示文摘 | Chung K Wright P Kedia B | 2003 | Review of Finan- cial Economics2003，，12： | 1 |
| 16 | Mechanism of coupled folding and binding of an intrinsically disordered protein显示文摘 | Sugase K Dyson H J Wright P E | 2007 | Nature2007，447，7147： | 1 |
| 17 | Particle packing in ceramic injection molding显示文摘 | Wright J K Edirisinghe M J Zhang J G | 1990 | Journal of the American Ceramic Society1990，73，9： | 1 |
| 18 | Hydrexyapatite nano and microparticles: correlation of particle properties with cytotox- icity and biostability 显示文摘 | Motskin M Wright DM Muller K | 2009 | Biomaterials2009，30，19： | 1 |
| 19 | Probabilistic modeling of aerothermal and thermal protection material response uncertainties显示文摘 | Wright M J Bose D Chen Y K | 2007 | AIAA Journal2007，45，2： | 1 |
| 20 | A low-field, low-cost Halbach magnet array for open-access NMR显示文摘 | Hills B P Wright K M Gilles D G | 2005 | Journal of Magnetic Resonance2005，175，： | 1 |
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