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| 1 | Expression of Beclin1 in non small cell lung cancer and its clinical significance显示文摘Objective:To investigate the expression of autophagy related gene;Beclin1 in human non-small cell lung cancer(NSCLC)tissues.Methods:Protein expression of Beclin1 was determined by immunofluorescence staining and Western Blot,mRNA expression was analyzed by RT-PCR.Results:Immunofluorescence staining revealed that the level of Beclin1 expression in lung cancer was significantly lower than that in adjacent noncancerous tissues and normal tissues(expression rate 8.3%,P=0.000).The Beclin1 mRNA expression in lung cancer,adjacent noncancerous tissues and normal tissues was 1.372(±0.475)1.721(±0.521)and 1.553(±0.554)when F = 15.0,P < 0.01.Beclin1 protein expression in lung cancer,adjacent noncancerous tissues and normal tissues was 3.453(±0.852)5.423(±1.351)and 6.878(±0.997)F = 11.2,P < 0.01.Conclusion:The protein and mRNA expression of Beclin1 in lung cancer was much lower than those in and around cancer tissues and normal tissues,those differences having statistical significance.However in adjacent noncancerous tissues and normal tissues,the expression showed no difference. | Quan Liu Jianjun Wang Yongcheng Pan Lifeng Meng Xi Zhan | 2008 | Journal of Nanjing Medical University2008，22，2： | 6 |
| 2 | Cupric ion release and cytotoxicity for Yuangong Cu-IUDs and the release behavior of indomethacin for medicated 220 Cu-IUD显示文摘These years Yuangong copper-bearing intrauterine devices (Cu-IUDs) have been used because of less side effects in use. The corrosion of copper is essential to the success of contraception, and the release behavior of indomethacin from medicated Cu-IUD is related to its therapeutic effect. In this study, analytical methods were established to investigate the release behavior of cupric ion of three kinds of Yuangong Cu-IUDs and indomethacin of medicated Yuangong 220 Cu-IUD. Cu-IUDs were incubated in simulated uterine solution (SUS). The concentrations of cupric ion and indomethacin were analyzed by flame atomic absorption spectrometer (FAAS) for 60 days and UV/vis ?3310 spectrophotometer for 60 days, respectively. The morphology of copper after corrosion was characterized by SEM. In addition, we detected cytotoxicity by MTT of L929 mouse fibroblasts cells caused by extracts of the three Yuangong Cu-IUDs. The release behavior of cupric ion for three kinds of Yuangong Cu-IUDs was biphasic, which consisted of the initial burst release and then slow and constant release. In vitro release experiment confirmed a biphasic release of indomethacin from Yuangong 220. The copper wire of Yuangong Cu-IUDs showed uneven corrosion. The RGR value of Yuangong 365 Cu-IUD was smaller than that of medicated Yuangong 220 Cu-IUD and RGR value of medicated Yuangong 220 Cu-IUD was smaller than that of Yuangong 300 Cu-IUD. The cupric ion release and indomethacin release showed biphasic. Indomethacin increased the cupric ion release rate and might diminish the adverse effects caused by burst release of cupric ion. The toxicity grade of these three Yuangong Cu-IUDs was 4. We should canvass the adverse events of Cu-IUDs based on practical experiments, and try our best to reduce the toxicity of Cu-IUDs. | CAO BianMei XI TingFei ZHENG YuDong YANG LiFeng ZHENG Qi | 2009 | Chinese Science Bulletin2009，54，18： | 6 |
| 3 | Toxicity and clinical reasonable application of Taoren(Semen Persicae) based on ancient and modern literature research显示文摘OBJECTIVE:To probe the toxicity and relative application theory of the commonly-used traditional Chinese herbal drug Taoren(Semen Persicae),and set up a correct attitude and principle and method to use Taoren(Semen Persicae) for treating the syndrome of stagnation of blood stasis and others in TCM clinic.METHODS:In this study,we analyzed and probed the ancient and modern literature research about Taoren(Semen Persicae),and summarized the realization of its toxicity and application contraindications in ancient herbals and the research assertion of its processing,drug-nature,pharmacologic actions,adverse reaction,and clinical reasonable application in modern literature.RESULTS:We found that some TCM doctors were worried about the effect of Taoren(Semen Persicae) 's disintegrating blood stasis to impair body's healthy Qi and its toxicity,and were not good at using this herb.And some patients were afraid of its toxic and side-effect not to take it.In the ancient and modern literatures some proper hates of Taoren(Semen Persicae) existed,and the toxicity component was also clear-cut,and the applications of Taoren(Semen Persicae) were in many fields especially the gynecological and traumatological diseases.The key root of toxicity generation and unreasonable application of Taoren(Semen Persicae) lies in taking without syndrome differentiation or using with overdosage.CONCLUSION:Under the precondition of correct processing,treatment based on syndrome differentiation,and taking the dosage stipulated by laws to apply Taoren(Semen Persicae) should be quite safe.The ancient and modern literature records and researches about Taoren(Semen Persicae) provide the determinate reference for understanding Taoren(Semen Persicae)'s efficacy and drug-nature(toxicity) more objectively and also for further correctly clinic recognition and research on Taoren(Semen Persicae). | Shengyan Xi Linchao Qian Haiying Tong Lifeng Yue Hui Zhao Dawei Wang Dawei Lu Pengcheng Li Xinrong Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 5 |
| 4 | STATE SPACE MODELING OF DIMENSIONAL MACHINING ERRORS OF SERIAL-PARALLEL HYBRID MULTI-STAGE MACHINING SYSTEM显示文摘最后的产品质量被累积决定,联合,从所有的产品质量变化的繁殖在多级式的生产驻扎系统(MMS ) 。建模并且变化繁殖的控制是必要的改进产品质量。然而,变化(SOV ) 的当前的溪流理论能仅仅解决单个 SOV 影响的问题产品质量。由于多重变化流的存在,有限研究在连续平行的混合多级式的生产系统(SPH-MMSs ) 在质量控制上被做了。一个州的空间模型和它的当模特儿的策略被开发在 SPH 公里描述多重变化溪流加起来。SOV 理论被扩大到 SPH 公里。系统模型的尺寸被归结为生产现实水平,并且模型的效果和可行性被一个用机器制造的盒子验证。 | XI Lifeng DU Shichang | 2007 | Chinese Journal of Mechanical Engineering2007，20，5： | 4 |
| 5 | Quasi-Lipschitz equivalence of quasi Ahlfors-David regular sets显示文摘Suppose compact sets E and F are quasi uniformly disconnected and quasi Ahlfors-David regular.This paper proves that E and F are quasi-Lipschitz equivalent if and only if they have the same Hausdorff dimension. | WANG Qin XI LiFeng | 2011 | Science China Mathematics2011，54，12： | 3 |
| 6 | Single-machine-based production scheduling model integrated preventive maintenance planning显示文摘 | PAN Ershun LIAO Wenzhu XI Lifeng | 2010 | The International Journal of Advanced Manufacturing Technology2010，50，14： | 1 |
| 7 | Modeling and optimizing maintenance schedule for energy systems subject to degradation显示文摘 | XIA Tangbin XI Lifeng ZHOU Xiaojun | 2012 | Computers - Industrial Engineering2012，63，3： | 1 |
| 8 | DCOM and MMS-based control software architecture automated manufacturing system显示文摘 | ZHOU Binghai XI Lifeng YU Chuanmeng | 2006 | International Journal of Advanced Manufacturing Technology2006，27，9： | 1 |
| 9 | Opportunistic Preventive Maintenance Scheduling for a Multi-unit Series System Based Dynamic Programming 显示文摘 | Xiaojun Zhou Lifeng Xi Jay Lee | 2009 | International Journal of Production Economics2009，118，2： | 1 |
| 10 | Preventive ma- intenance optimization for a multi -component system un- der changing job shop schedule 显示文摘 | ZHOU Xiaojun LU Zhiqiang XI Lifeng | 2012 | Reliability Engi- neering and System Safety2012，，101： | 1 |
| 11 | Identifying Source(s) of Out-of-control Signals in Multivariate Manufacturing Processes Using Selective Neural Network Ensemble 显示文摘 | Yu Jianbo Xi Lifeng Zhou Xiaojun | 2009 | Engineering Applications of Artificial Intelligence2009，22，1： | 1 |
| 12 | Preventive ma- intenance scheduling for repairable system with deteriora- tion显示文摘 | LIAO Wenzhu PAN Ershun XI Lifeng | 2010 | Journal of Intelligent Manufacturing2010，21，6： | 1 |
| 13 | Hierarchically Designed SiOx/SiOy Bilayer Nanomembranes as Stable Anodes for Lithium Ion Batteries显示文摘 | Lin Zhang Junwen Deng Lifeng Liu Wenping Si Steffen Oswald Lixia Xi Manab Kundu Guozhi Ma Thomas Gemming Stefan Baunack Fei Ding Chenglin Yan Oliver G. Schmidt | 2014 | Adv Mater2014，，26： | 1 |
| 14 | Reliability-centered pre- dictive maintenance scheduling for a continuously monitored system subject to degradation显示文摘 | ZHOU Xiaojun XI Lifeng LEE J | 2007 | Reliability Engineering and System Safety2007，92，4： | 1 |
| 15 | DCOM and MMS based control software architect ure automated manufacturing system显示文摘 | ZHOU Binghai XI Lifeng YU Chuanmeng | 2006 | Interna- tional Journal of Advanced Manufacturing Tech- nology2006，，： | 1 |
| 16 | Design for diagnosability of multistation manufacturing systems based on sensor allocation optimization显示文摘 | SUN Jiwen XI Lifeng PAN Ershun | 2009 | Computers in Industry2009，60，7： | 1 |
| 17 | Reliability-centered predictive maintenance scheduling for a continuously monitored system subject to degradation显示文摘 | Zhou Xiaojun Xi Lifeng Lee J | 2007 | Reliability Engineering and System Safety2007，92，4： | 1 |
| 18 | A prozctive approach for simultaneous berth and quay crane scheduling problem with stochastic arrival and han- dling time显示文摘 | HAN Xiaole LU Zhiqiang XI Lifeng | 2010 | European Journal of Operational Re- search2010，207，： | 1 |
| 19 | A heuristic for the quay crane scheduling problem based on contiguous bay crane operations显示文摘 | LU Zhiqiang HAN Xiaole XI Lifeng | 2012 | Computers & Operations Research2012，39，12： | 1 |
| 20 | Design for diagnosability of muhistation manufacturing systems based on sensor allocation optimization 显示文摘 | SUN Jiwen XI Lifeng PAN Er'shun | 2009 | Computers in Industry2009，69，7： | 1 |
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