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| 1 | Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis显示文摘尖锐心肌的梗塞(AMI ) 是一个威胁生活的事件。甚至与及时处理,尖锐 ischemic 心肌的损害和随后的局部缺血灌注损害(IRI ) 能仍然是困难的问题处理。除了放射学并且另外的辅助考试,适用的心脏的 biomarkers 的实验室测试为这混乱监视的早诊断和结束也是必要的。心类型丰满的酸绑定蛋白质(H-FABP ) 主要在 cardiomyocytes 内存在,最近为心肌的损害作为潜在地有希望的 biomarker 出现了。在这评论,我们在对心肌的损害和 IRI 的评价讨论 H-FABP 的敏感和特性,特别在早阶段,和它与另外的通常使用的心脏的 biomarkers 比较的长期的预示的价值,包括肌球素( Mb ),心脏的 troponin 我( cTnI ),肌酸 kinase MB ( CK-MB ),C反应的蛋白质( CRP ),肝糖 phosphorylase isoenzyme BB ( GPBB ),和高敏感的心脏的 troponin T ( hs-cTnT )。有另外的 biomarkers 的 H-FABP 的联合申请的潜力和值也被讨论。最后, H-FABP 的前景被总结;几个技术问题被讨论在临床的实践便于 H-FABP 的更宽的申请。 | Xiao-dong YE Yi HE Sheng WANG Gordon T WONG Michael G IRWIN Zhengyuan XIA | 2018 | Acta Pharmacologica Sinica2018，39，7： | 72 |
| 2 | Simulations and software development for the Hard X-ray Imager onboard ASO-S显示文摘China’s first solar mission,the Advanced Space-based Solar Observatory(ASO-S),is now changing from Phase B to Phase C.Its main scientific objectives are summarized as’1M2B’,namely magnetic field and two types of bursts(solar flares and coronal mass ejections).Among the three scientific payloads,Hard X-ray Imager(HXI)observes images and spectra of X-ray bursts in solar flares.In this paper,we briefly report on the progresses made by the HXI science team(data and software team)during the design phase(till May 2019).These include simulations of HXI imaging,optimization of HXI grids,development of imaging algorithms,estimation of orbital background,as well as in-orbit calibration plan.These efforts provided guidance for the engineering,improved HXI’s imaging capability and reduced the cost of the instrument. | Yang Su Wei Liu You-Ping Li Zhe Zhang Gordon JHurford Wei Chen Yu Huang Zhen-Tong Li Xian-Kai Jiang Hao-Xiang Wang Fan-Xiao-Yu Xia Chang-Xue Chen Wen-Hui Yu Fu Yu Jian Wu Wei-Qun Gan | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 7 |
| 3 | Cytotoxic effect of interleukin-8 in retinal ganglion cells and its possible mechanisms显示文摘AIM: To investigate the effect of interleukin-8(IL-8) on neural retinal ganglion cells(RGCs) and whether it can be alleviated by G31P. METHODS: RGC-5 cells were exposed to IL-8 with or without its specific receptor antagonist G31P for 24h, and the cell viability was assessed by Cell Counting Kit 8(CCK-8). Apoptosis was measured by examining nuclear morphology and quantifying with flow cytometry. Reverse transcription quantitative real-time polymerase chain reaction(RT-qP CR) and Western blot were used to investigate the expression of apoptosis-related genes. RESULTS: CCK-8 assay showed that IL-8 significantly inhibits the viability of RGC-5 cells in a dose-dependent manner. Cell apoptosis assays exhibited higher apoptotic rate in IL-8 treatment group compared to control group. We further found that IL-8 could promote Bax and caspase-3 expressions, but decrease the level of Bcl-2 in the aspect of m RNA and protein. However, pre-treatment with G31P partly attenuated these effects in RGC-5 cells(P<0.05).CONCLUSION: These results indicate that anti-proliferation effects of IL-8 through induction of cell apoptosis regulated by Bcl-2, Bax and caspase-3 expressions, can be ameliorated by G31P. | Jing-Jing Wang Walana Williams Bing Wang Jing Wei Xia Lu Jya-Wei Cheng John R Gordon Jing-Min Li Fang Li | 2018 | International Journal of Ophthalmology(English edition)2018，11，8： | 3 |
| 4 | Three-dimensional bioprinting speeds up smart regenerative medicine显示文摘Biological materials can actively participate in the formation of bioactive organs and can even control cell fate to form functional tissues that we name as the smart regenerative medicine(SRM). The SRM requires interdisciplinary efforts to finalize the pre-designed organs. Three-dimensional(3D) printing, as an additive manufacturing technology, has been widely used in various fields due to its high resolution and individuation. In SRM, with the assistance of 3D printing, cells and biomaterials could be precisely positioned to construct complicated tissues. This review summarizes the state of the SRM advances and focuses in particular on the 3D printing application in biofabrication. We further discuss the issues of SRM development and finally propose some approaches for future 3D printing, which involves SRM. | Qi Gu He Zhu Jing Li Xia Li Jie Hao Gordon G.Wallace Qi Zhou | 2016 | National Science Review2016，3，3： | 2 |
| 5 | 鞘内注射吗啡预处理激活大鼠δ、κ、μ受体致心肌保护显示文摘背景鞘内注射小剂量吗啡可产生与静脉注射吗啡相似的心肌保护作用,但鞘内注射吗啡预处理(IT—MPC)与缺血预处理(IPC)作用强度的差别还未知,IT-MPC是否由阿片类受体所介导也未阐明。因此,本实验比较IT—MPC与IPC作用强度差别并探讨阿片类受体的作用。方法80只SD大鼠麻醉后开胸,成功置入鞘内导管后随机分为13组(n=6—7)。IPC组接受3次5分钟缺血-5分钟再灌注的心肌IPC(阻闭左冠状动脉),随之给予30分钟缺血-2小时再灌注诱导心肌缺血再灌注(IR)损伤。IT-MPC组按剂量不同分为4个亚组(分别是0.03、0.3、3及30μg/kg),以3次5分钟注射-5分钟间停的模式平均注入鞘内,随之诱导IR损伤。静脉注射吗啡预处理组(IV-MPC)组经静脉给予吗啡300μg/kg,对照组鞘内给予10μl生理盐水。受体阻滞剂组选择在IT—MPC(3μg/kg)前分别给予选择性δ、κ、μ受体阻滞剂NTD、nor-BNI及CTOP,以评价阿片类受体亚型的作用。通过2,3,5-tripheny ltetrazolium染色,计算心肌梗死面积(IS),即梗死心肌占缺血危险区(AAR)的百分比。结果与对照组相比,鞘内注射0.3~30μg/kg吗啡降低心肌IS,3组IS/AAR分别为33%±10%(0.3μg/kg)、29%±10%(3μg/kg)、29%±16%(30μg/kg),对照组为53%±8%(P〈0.01)。IT-MPC降低心肌IS/AAR程度与IV-MPC(33%±6%,P=0.84)及IPC(22%±4%,P=0.41)相近。注射选择性受体阻滞剂后,由IT-MPC(3μg/kg)产生的心肌预处理效果降低(NTD+IT-MPC,50%±9%:nor-BNI+IT-MPc,43%±6%;CTOP+IT—MPC,53%±9%;与对照组相比,P=0.14)。结论IT—MPC产生与IPC及IV—MPC相近的心肌保护作用,其机制涉及到δ、κ、μ受体。 | Rui Li Gordon T. C. Wong Tak Ming Wong Ye Zhang, MD Zhengyuan Xia Michael G. Irwin 潘鹏(译) 李文志(校) | 2009 | 麻醉与镇痛2009，，6： | 2 |
| 6 | Development of a Niobium Clad PEM Fuel Cell Bipolar Plate Material显示文摘 | Gordon Xia GaryYang Z | | International Journal of Hydrogen Energy0，，： | 1 |
| 7 | Kinetic studies of methanol steam reforming over Pd/ZnO catalyst using a microchannel reactor 显示文摘 | CHUNSHE CAO GORDON XIA JAMIE HOLLADAY | 2004 | Applied Catalysis A: General2004，262，1： | 1 |
| 8 | Comparison of treatment plans involving intensity modulated radiotherapy for nasopharyngeal carcinoma显示文摘 | Xia Ping Fu Karen K Wong Gordon W | 2000 | Int J Radiat Oncol Biol Phys2000，48，2： | 1 |
| 9 | Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma显示文摘 | Ping Xia Karen K Fu Gordon W Wong Clayton Akazawa Lynn J Verhey | 2000 | International Journal of Radiation Oncology, Biology, Physics2000，，2： | 1 |
| 10 | Kinetic studies of methanol steam reforming over Pd/ZnO catalyst using a microchannel reactor显示文摘 | Gordon Xia Jamie Holladay | 2004 | Applied Catalysis A:General2004，262，： | 1 |
| 11 | Comparison of treatment plans involving intensity modulated radiotherapy for nasopharyngeal carcinoma显示文摘 | Xia Ping Fu Karen K Wong Gordon W | 2000 | Int J Radiat Oncol Boil Phys2000，48，2： | 1 |
| 12 | Distribution of PAEs in the middle and lower reaches of the Yellow River, China显示文摘 | Yujuan Sha Xinghui Xia Zhifeng Yang Gordon H. Huang | 2007 | Environmental Monitoring and Assessment (-)2007，，1： | 1 |
| 13 | Kinetic Studies of Methanol Steam Reforming over Pd/ZnO Catalyst Using a Microchannel Reactor 显示文摘 | CAO Chunshe XIA Gordon Holladay J | 2004 | Applied Catalysis A: General2004，262，： | 1 |
| 14 | 疫苗竞赛的领先者显示文摘今年4月,萨拉·吉尔伯特(Sarah Gilbert)的三个孩子决定参加一项新冠病毒实验疫苗的人体试验。他们是三胞胎,今年21岁,都在大学读生物化学专业。这是他们的母亲带领牛津大学一个团队研发的疫苗。关于参加人体试验,家里从未郑重其事地讨论过。 | Stephanie Baker Xia Gordon(插画) Vernon Silver James Paton 冯艳彬(译) 许诺(译) | 2020 | 商业周刊(中文版)2020，，12： | 0 |
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