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| 1 | Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction显示文摘 | Mei Hua Jiang Bing Cai Ying Tuo Jiancheng Wang Zhi Jun Zang Xiang'an Tu Yong Gao Zhijian Su Weiqiang Li Guilan Li Min Zhang Jianwei Jiao Zi Wan Chunhua Deng Bruce T Lahn Andy Peng Xiang | 2014 | Cell Research2014，24，12： | 14 |
| 2 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 3 | Establishment and characterization of two new human embryonic stem cell lines,SYSU-1 and SYSU-2显示文摘背景人的胚胎的干细胞能在 vitro 无止境地宣传并且能区分进所有三胚胎的细菌层的衍生物。主要在他们的潜力包围人的胚胎的干细胞谎言生产的兴奋专业化能被用于的房间移植治疗。然而,进一步的调查与改变基因背景要求另外的房间线。因此,导出并且建立更多的人的胚胎的干细胞线的努力是高度,从施主的 warranted.Methods 剩余胚胎(胚囊) 被用来由 immunosurgery 孤立内部房间团。所有房间在照耀的鼠科的胚胎的成纤维细胞上连续地是有教养的喂层和多半人的胚胎的干细胞殖民地被房间表面标记染色, karyotyping 和 teratoma formation.Results 随后描绘二根人的胚胎的干细胞线(SYSU-1 和 SYSU-2 ) 从剩余胚胎被建立。二根线表示包括碱的磷酸酶, SSEA- 4, Tra-1-60, Oct-4, Nanog 和 Rex-1.They 的标记在延长段落以后与正常 karyotype 处于无差别的状态仍然是的几 pluripotency 并且能在 vivo.Conclusion 在 vitro 和 teratoma 形成胚胎植物或动物身体二根新人的胚胎的干细胞线从剩余胚胎被建立了。他们能被用来理解 selfrenewal 和区分的机制并且为再生药提供更多的选择。 | HUANG Guo LI Wei-qiang CHEN Rui CHEN Zhen-guang ZHANG Xiu-ming MAO Fu-xiang HUANG Shao-liang LI Shu-nong Bruce T Lahn Andy Peng Xiang | 2007 | Chinese Medical Journal2007，，7： | 3 |
| 4 | Characteristics of Rat Lumbar Vertebral Body Bone Mineral Density and Differential Segmental Responses to Sex Hormone Deficiency:a Clinical Multidetector Computed Tomography Study显示文摘Objective To investigate sex hormone deficiency related osteoporosis and efficacy of different therapies. Methods Orchiectomized and ovariectomized rat models are used to investigate sex hormone deficiency related osteoporosis and efficacy of different therapies. A rat vertebral body can be longitudinally divided into central portion, which contain more trabecular bone, and para-endplate portions which contain more compact bone. In matured male and female Wistar and Sprague-Dawley rat lumbar spines, we investigated baseline bone mineral density (BMD) characteristics and the differential segmental responses in bone loss within the lumbar vertebral body post gonadal surgery with clinical multidetector computed tomography. Results Para-endplate sections had a higher BMD than central sections. The cephalad para-endplate sections had a higher BMD than the caudad para-endplate sections. Eight weeks after gonadal removal, there was more bone loss in central sections than para-endplate sections. The relative difference of bone loss between para-endplate and central sections was more apparent in male rats than in female rats. There was more bone loss in caudad sections than cephalad sections; this lead to a further increase of BMD difference between caudad para-endplate sections and cephalad para-endplate sections post gonadal surgery. Conclusion The approach described in this study provided a consistent way to study BMD change within predominantly compact bone portion and trabecular bone portion of the vertebral body. | DENG Min WANG Yi Xiang James F. GRIFFITH LU Gang Anil T AHUJA POON Wai S | 2012 | Biomedical and Environmental Sciences2012，25，6： | 2 |
| 5 | Gestational diabetes mellitus显示文摘 | Buchanan T A Xiang A H | 2005 | J Clin Invest2005，115，3： | 1 |
| 6 | Reliability evaluation of chloride diffusion in fatigue damaged concrete显示文摘 | XIANG T ZHAO R | 2007 | Engineering Structures2007，，29： | 1 |
| 7 | Hydrothermal preparation of boehmite nanorods by selective adsorption of sulfate显示文摘 | He T B Xiang L Zhu S L | 2008 | Langmuir2008，24，： | 1 |
| 8 | Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese:significant linkage to chromosome 6q21-q23 and chromosome 1 q21-q24显示文摘 | Xiang K Wang Y Zheng T | | 0，，： | 1 |
| 9 | PAPR Reduction of OFDM Signals Using Partial Transmit Sequences with Low Computational Complexity显示文摘 | Jiang T Xiang W Richardson P C | 2007 | IEEE Transactions on Broadcasting2007，53，3： | 1 |
| 10 | Role of Wnt/β- catenin sig- naling in epithelial differentiation of lung resident mesenchy- mal stem cells 显示文摘 | SHI C LV T XIANG Z | 2015 | J Cell Biochem2015，116，8： | 1 |
| 11 | Paleoenvironmental change in the middle Okinawa Trough since the last deglaciation:Evidence from the sedimentation rate and planktonic foraminiferal record显示文摘 | Xiang R Sun Y Li T | 2007 | Palaeogeography Palaeoclimatology Palaeoecology2007，243，： | 1 |
| 12 | The locomotion,shape and pseudopodial dynamics of unstimulated dictyostelium cells are not random显示文摘 | Peter J P Xiang Wei | 1993 | J Cell Sci1993，106，4： | 1 |
| 13 | Influence of chain ordering on the selectivity of dipalmitoylphosphatidylcholine bilayer membranes for permeant size and shape显示文摘 | Xiang T X Anderson B D | 1998 | Biophys J1998，75，6： | 1 |
| 14 | Permeability of acetic acid across gel and liquid-crystalline lipid bilayers conforms to free-surface-area theory显示文摘 | Xiang T X Anderson B D | 1997 | Biophys J1997，72，1： | 1 |
| 15 | Reliability Evaluation of Chlo-ride Diffusion in Fatigue Damaged Concrete显示文摘 | XIANG T Y ZHAO R D | 2007 | Engineer-ing Structure2007，29，7： | 1 |
| 16 | NOD2/CARDI5 gene mutation identified in a Chinese family with Blau syndrome 显示文摘 | Xiang H Zhang T Chen M | 2012 | Molecul Vision2012，18，： | 1 |
| 17 | Influence of environmental stresses on the physicochemical stability of orange oil bilayer emulsions coated by lactoferrin-soybean soluble polysaccharides and lactoferrin-beet pectin 显示文摘 | Zhao J Xiang J Wei T | 2014 | Food Research International2014，66，： | 1 |
| 18 | Antioxidant constituents of Caragana tibetica 显示文摘 | Xiang T Uno T Ogino F eta| | 2005 | Chem Pharm Bull2005，53，9： | 1 |
| 19 | Grafting of zwitterion from polysulfone membrane via surface-initiated ATRP with enhanced antifouling property and biocompatibility 显示文摘 | YUE W W LI H J XIANG T | 2013 | J Membr Sci2013，446，： | 1 |
| 20 | Heralded noiseless linear am- plification and distillation of entanglement 显示文摘 | Xiang G Y Ralph T C | 2010 | Nature Photonics2010，4，5： | 1 |
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