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| 1 | Retroperitoneal laparoendoscopic single-site ureterolithotomy versus conventional laparoscopic ureterolithotomy显示文摘 | Qiao Peng Zhang Junhui Wang Jianwen Tian Xiquan Niu Yinong Xing Nianzeng | 2014 | Chinese Medical Journal2014，，5： | 6 |
| 2 | Long-time precipitation reduction and nitrogen deposition increase alter soil nitrogen dynamic by influencing soil bacterial communities and functional groups显示文摘The effects of precipitation reduction and nitrogen deposition increase on soil bacterial communities and functions impact soil nitrogen cycling. Seasonal changes could modify the effects of precipitation reduction and nitrogen deposition increase on bacterial communities and functions by changing soil environments and properties. Understanding soil microbial communities and the seasonal response of functions to precipitation reduction and nitrogen deposition increase may be important for the accurate prediction of changes in the soil nitrogen dynamics. Thus, a long-term field simulation experiment of nitrogen deposition increase and throughfall exclusion was established to investigate soil bacterial communities’ response to nitrogen deposition increase and/or precipitation reduction, with no nitrogen deposition increase and no precipation reduction as a control, in a temperate forest. We examined soil bacterial communities(Illumina sequencing) under different treatments during the winter, freezing-thawing cycle periods(FTCs), and growing season. The bacterial functional groups were predicted by the FAPROTAX database. The results showed that nitrogen deposition increase, precipitation reduction, the combined effect of nitrogen deposition increase and precipitation reduction, and seasonal changes significantly altered the soil bacterial community composition.Interestingly, by combining the result of a previous study in which nitrogen deposition increase increased the nitrous oxide flux in the same experimental system, the loss of soil nitrogen was increased by the decrease in denitrification and increase of nitrification bacteria under nitrogen deposition increase,while ammonification bacteria significantly increased and N-fixing bacteria significantly decreased with precipitation reduction compared to the control. In relation to seasonal changes, the aromatic-degrading, cellulolytic, and ureolytic bacteria were lowest during FTCs, which indicated that FTCs might inhibit biodegradation. Nitrification and nitrite-oxidizing bacteria increased with nitrogen deposition increase or precipitation reduction and in FTCs compared to the control or other seasons. The interaction between treatment and season significantly changed the soil bacterial communities and functions. These results highlight that nitrogen deposition increase, precipitation reduction, seasonal changes, and their interactions might directly alter bacterial communities and indirectly alter the dynamics of soil N. | Guoyong YAN Yajuan XING Shijie HAN Junhui ZHANG Qinggui WANG Changcheng MU | 2020 | Pedosphere2020，30，3： | 6 |
| 3 | Formation of uniform reduced graphene oxide films on modified PET substrates using drop-casting method显示文摘In this work,uniform reduced graphene oxide(RGO) films were formed on poly-(ethylene terephthalate)(PET) substrates using a simple drop-casting method.We investigated four types of substrates:unmodified PET,polydopamine-coated PET.carboxyl-group-modified PET,and alkyl-group-modified PET.Upon water evaporation,the surface of the polydopamine-modified PET substrates can interact with the reduced graphene oxide sheets to form flattened and continuous RGO films,which exhibit a sheet resistance of 21.75 kΩ/sq at 82%transmittance.The result indicates that the properties of the surface groups determined whether uniform and flattened RGO films could be formed on the substrates.Hence,we proposed a simple and effective way to produce transparent and conductive films in which the catechol unit exhibits a great effect on the deposition of uniform RGO films on PET substrates. | Chunlin Zhao Li Xing Junhui Xiang Lijie Cui JianbinJiao Huazheng Sai Zhenyou Li Fei Li | 2014 | Particuology2014，12，6： | 4 |
| 4 | Generation of Nb-enriched mafic rocks and associated adakitic rocks from the southeastern Central Asian Orogenic Belt:Evidence of crust-mantle interaction显示文摘Melting of subducting oceanic lithosphere and associated melt-mantle interactions in convergent plate margins require specific geodynamic environment that allows the oceanic slab to be abnormally heated.Here we focus on the Early Mesozoic mafic rocks and granite porphyry,which provide insights into slab melting processes associated with final closure of the Paleo-Asian Ocean.The granite porphyry samples are calc-alkaline and distinguished by high Sr contents,strong depletion of heavy rare earth elements,resulting in high(La/Yb);and Sr/Y ratios,and negligible Eu anomalies.Based on their high Na_(2)O and Mg O,low K_(2)O contents,positiveε_(Hf)(t)andε_(Nd)(t)and low(^(87)Sr/^(86)Sr)ivalues,we propose that the granite porphyry was likely derived from partial melting of subducting Paleo-Asian oceanic crust.The Nb-enriched mafic rocks are enriched in Rb,Th,U,Pb and K,and depleted in Nb,Ta,Ba,P and Ti,corroborating a subduction-related origin.Their heterogeneous Sr-Nd-Hf-O isotopic compositions and other geochemical features suggest that they were likely derived from partial melting of peridotitic mantle wedge interacted with oceanic slab-derived adakitic melts.Trace element and isotope modeling results and elevated zirconδ^(18)O values suggest variable subducting sediments input into the mantle wedge,dominated by terrigenous sediments.Synthesizing the widely-developed bimodal rock associations,conjugated dikes,thermal metamorphism,tectonic characteristics,paleomagnetic constraints,and paleogeographical evidence along the Solonke-Changchun suture zone,we identify a slab window triggered by slab break-off,which accounts for slab melting and formation of the Nb-enriched mafic rocks and associated adakitic granite porphyry in southeastern Central Asian Orogenic Belt. | Yan Jing Wenchun Ge M.Santosh Yu Dong Hao Yang Zheng Ji Junhui Bi Hongying Zhou Dehe Xing | 2022 | Geoscience Frontiers2022，13，2： | 2 |
| 5 | Seismic Images of Shallow Waters over the Shatsky Rise in the Northwest Pacific Ocean显示文摘Recent studies have demonstrated the ability of seismic oceanography to reveal finescale vertical structures of water column in the oceans based on multichannel seismic(MCS)reflection data.Such information can clarify the dynamic processes of mixing,exchange,and translation of water mass and energy.In this study,we present four MCS lines and satellite data to show high-resolution seismic images of shallow waters over the Shatsky Rise in the Northwest Pacific Ocean,where the Kuroshio Exten-sion passes and bifurcates.One of our MCS transects crossed the center of an anticyclonic warm eddy on August 28,2010,confirmed by satellite data such as sea level anomaly(SLA),geostrophic current anomaly(GCA),and sea surface temperature anomaly(SSTa).The seismic image showed that the eddy vertical structure featured a bowl-like shape and onion-like internal layering.The slightly tilted(<0.5°)surface of the eddy was 400m below the sea surface,indicating a subsurface eddy.The eddy was inferred to have a radius of 50 km and a maximum thickness of 500m.Other MCS sections demonstrated the submesoscale structure of oceanfronts,characterized by the dipping reflectors(>2°-3°)at the boundaries between water masses with differing properties.In addition,the discrepancies in SLA,GCA,and SSTa between water masses resulted in different seismic reflectivities.The water masses with high SLA,anticyclonic GCA and positive SSTa featured high-amplitude,continuous,clear-layered,and non-linear reflections,whereas those with low SLA,cyclonic GCA,and negative SSTa were associated with weak,fragmented,less stratification,and more linear reflectors. | ZHANG Jinchang LUO Yiming XING Junhui | 2021 | Journal of Ocean University of China2021，20，5： | 1 |
| 6 | Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma显示文摘Background:Increased hypoxia-inducible factor 2α(HIF2α)activation is a common event in clear cell renal cell carcinoma(ccRCC)progression.However,the function and underlying mechanism of HIF2α in ccRCC remains uninvestigated.We conducted this study to access the potential link between junction plakoglobin(JUP)and HIF2αin ccRCC.Methods:Affinity purification and mass spectrometry(AP-MS)screening,glutathione-s-transferase(GST)pull-down and co-immunoprecipitation(Co-IP)assays were performed to detect the interacting proteins of HIF2α.Quantitative PCR(qPCR)and Western blotting were used to detect the expression of JUP in human ccRCC samples.Luciferase reporter assays,chromatin immunoprecipitation(ChIP),cycloheximide chase assays,and ubiquitination assays were conducted to explore the regulation of JUP on the activity of HIF2α.Cell Counting Kit-8(CCK-8)assays,colony formation assays,transwell assays,and xenograft tumor assays were performed to investigate the effect of JUP knockdown or overexpression on the tumorigenicity of renal cancer cells.Results:We identified JUP as a novel HIF2α-binding partner and revealed an important role of JUP in recruiting von Hippel-Lindau(VHL)and histone deacetylases 1/2(HDAC1/2)to HIF2α to regulate its stability and transactivation.JUP knockdown promoted and overexpression suppressed the tumorigenicity of renal cell carcinoma in vitro and in vivo.Importantly,the low expression of JUP was found in clinical ccRCC samples and correlated with enhanced hypoxia scores and poor treatment outcomes.Conclusion:Taken together,these data support a role of JUP in modulating HIF2α signaling during ccRCC progression and identify JUP as a potential therapeutic target. | Ke Chen Jin Zeng Yi Sun Wei Ouyang Gan Yu Hui Zhou Yangjun Zhang Weimin Yao Wei Xiao Junhui Hu Jinchun Xing Kefeng Xiao Lily Wu Zhiqiang Chen Zhangqun Ye Hua Xu | 2021 | Cancer Communications2021，41，4： | 1 |
| 7 | Stratigraphic Sequence and Sedimentary Systems in the Middle-Southern Continental Slope of the East China Sea from Seismic Reflection Data: Exploration Prospects of Gas Hydrate显示文摘Many evidences for gas hydrate bearing sediments had been found in the continental slope of the East China Sea,such as bottom simulating reflections(BSRs),undersea gas springs,pyrite associated with methane leakage,mud diapirs/mud volcanos,bottom-water methane anomalies and so on.In this study,six key stratigraphic interfaces including T_0(seafloor),T_1(LGM,23 kyr B.P.),T_2(2.58 Myr),T_3(5.33 Myr),T_4(11.02 Myr)and T_5(16.12 Myr)were identified,and then five third-order sequences of SQIII1 to SQIII5 were divided.However,T5 in southern continental slope is not found,which shows that the middle-northern Okinawa Trough had begun to rift in the early Miocene,earlier than the southern segment.Four system tracts including lowstand systems tract(LST),transgressive systems tract(TST),highstand systems tract(HST)and falling stage systems tract(FSST)are further divided.The marine erosion interface of 11.02 Myr and regressive unconformity interface of 23 kyr B.P.indicate two large-scale sea level drop events in the research area.Seven typical seismic facies identified in the continental slope are continental shelf-edge deltas,littoral fluvial-delta plains,incised channels or submarine canyons,slope fans,submarine fans or coastal sandbars,littoral-neritic finegrained sediments,mud volcanos and some other geological bodies respectively.The minimum water depth for hydrate occurrence in the Okinawa Trough is 630 m,and the thickness of gas hydrate stability zone in continental slope is between 0 and 590 m.The calculated bottom boundary of hydrate stability zone is slightly deeper than BSRs on the seismic sections.The re-depositional turbidite sand bodies,such as canyon channels,slope fans and submarine fans developed in Quaternary strata,are the predominant hydrate reservoirs.According to developing process,the dynamic accumulation of hydrate systems can be divided into three evolutionary stages including canyon erosion and hydrate stability zone migration stage,sediments destabilizing and methane leakage stage,and channel filling and hydrate re-occurrence stage. | LI Deyong CHEN Hongyan XU Shujuan XING Junhui CHENG Honggang WANG Jinkai | 2019 | Journal of Ocean University of China2019，18，6： | 1 |
| 8 | Moso bamboo expansion decreased soil heterotrophic respiration but increased arbuscular mycorrhizal mycelial respiration in a subtropical broadleaved forest显示文摘Moso bamboo(Phyllostachys Pubescens)expansion into adjacent forests has been widely reported to affect plant diversity and its association with mycorrhizal fungi in subtropical China,which will likely have significant impacts on soil respiration.However,there is still limited information on how Moso bamboo expansion changes soil respiration components and their linkage with microbial community composition and activity.Based on a mesh exclusion method,soil respirations derived from roots,arbuscular mycorrhizal(AM)mycelium,and free-living microbes were investigated in a pure Moso bamboo forest(expanded),an adjacent broadleaved forest(nonexpanded),and a mixed bamboo-broadleaved forest(expanding).Our results showed that bamboo expansion decreased the cumulative CO_(2)effluxes from total soil respiration,root respiration and soil heterotrophic respiration(by 19.01%,30.34%,and 29.92%on average),whereas increased those from AM mycelium(by 78.67%in comparison with the broadleaved forests).Bamboo expansion significantly decreased soil organic carbon(C)content,bacterial and fungal abundances,and enzyme activities involved in C,N and P cycling whereas enhanced the interactive relationships among bacterial communities.In contrast,the ingrowth of AM mycelium increased the activities ofβ-glucosidase and N-acetyl-β-glucosaminidase and decreased the interactive relationships among bacterial communities.Changes in soil heterotrophic respiration and AM mycelium respiration had positive correlations with soil enzyme activities and fungal abundances.In summary,our findings suggest that bamboo expansion decreased soil heterotrophic respiration by decreasing soil microbial activity but increased the contribution of AM mycelial respiration to soil C efflux,which may potentially increase soil C loss from AM mycelial pathway. | Wenhao Jin Jiaying Tu Qifeng Wu Liyuan Peng Jiajia Xing Chenfei Liang Shuai Shao Junhui Chen Qiufang Xu Hua Qin | 2023 | Forest Ecosystems2023，10，3： | 1 |
| 9 | Hypertension: an immunologic disease?显示文摘 | Tao Xing Feng Wang Junhui Li Niansong Wang | 2012 | Journal of Hypertension2012，，12： | 1 |
| 10 | Spatial pattern of macrobenthic communities along a shelf-slope-basin transect across the Bering Sea显示文摘Due to its unique geological location, the Bering Sea is an ideal place to investigate the water exchange and ecosystem connectivity of the Pacific Ocean–Arctic Ocean and subarctic–Arctic region. Based on a number of summer surveys(July to September, 2010, 2012 and 2014), macrobenthic communities and their spatial-temporal patterns are exhibited for the majority of the Bering Sea(53°59′–64°36′N). The results show that the macrobenthic communities were dominated by northern cold-water species and immigrant eurythermic species, and the communities assumed a dispersed and patchy distribution pattern. Polychaetes(Scoloplos armiger), crustaceans(Ceradocus capensis) and sea urchins(Echinarachnius parma) were the main dominant groups in the shallow shelves; the sea star(Ctenodiscus crispatus) and the brittle star(Ophiura sarsii) were the main dominant groups in the continental slope; whereas small polychaetes(Prionospio malmgreni) dominated the basin area. Sediment type, water depth, and currents were the major factors affecting the structure and spatial distribution of the macrobenthic communities. Compared with other seas, the shallow areas of the Bering Sea showed an extremely high-standing biomass. In particular, the northern shelf area(north of St. Lawrence Islands and west of 170°W),which is primarily controlled by Anadyr Water, is an undersea oasis. In contrast, a deficiency in the downward transport of particulate organic carbon has resulted in a desert-like seabed in the basin area. By comparing our results to previous studies, we found that macrobenthic communities of the Bering Sea have undergone significant structural changes in recent decades, resulting in a decrease in abundance and an increase in biomass.In addition, populations of amphipods and bivalves in the northern shelves have decreased significantly and have been gradually replaced by other species. These changes might be associated with advanced seasonal ice melting,changes in organic carbon input, and global warming, indicating that large-scale ecosystem changes have been occurring in the Bering Sea. | LIN Heshan LIU Kun WANG Jianjun HUANG Yaqin LI Zhong LIN Junhui HE Xuebao ZHANG Shuyi MOU Jianfeng WANG Yu XING Bingpeng | 2018 | Acta Oceanologica Sinica2018，37，6： | 1 |
| 11 | Influence of Piston Number on Churning Losses in Axial Piston Pumps显示文摘Raising the rotational speed of an axial piston pump is useful for improving its power density;however,the churning losses of the piston increase significantly with increasing speed,and this reduces the performance and efficiency of the axial piston pump.Currently,there has been some research on the churning losses of pistons;however,it has rarely been analyzed from the perspective of the piston number.To improve the performance and efficiency of the axial piston pump,a computational fluid dynamics(CFD)simulation model of the churning loss was established,and the effect of piston number on the churning loss was studied in detail.The simulation analysis results revealed that the churning losses initially increased as the number of pistons increased;however,when the number of pistons increased from six to nine,the torque of the churning losses decreased because of the hydrodynamic shadowing effect.In addition,in the analysis of cavitation results,it was determined that the cavitation area of the axial piston pump was mainly concentrated around the piston,and the cavitation became increasingly severe as the speed increased.By comparing the simulation results with and without the cavitation model,it was observed that the cavitation phenomenon is beneficial for the reduction of churning losses.In this study,a piston churning loss test rig that can eliminate other friction losses was established to verify the accuracy of the simulation results.A comparative analysis indicated that the simulation results were consistent with the actual situation.In addition,this study also conducted a simulation study on seven and nine piston pumps with the same displacement.The simulation results revealed that churning losses of the seven pistons were generally greater than those of the nine pistons under the same displacement.In addition,regarding the same piston number and displacement,reducing the pitch circle radius of piston bores is effective in reducing the churning loss.This research analyzes the effect of piston number on the churning loss,which has certain guiding significance for the structural design and model selection of axial piston pumps. | Ying Li Xing Chen Hao Luo Junhui Zhang Jin Zhang | 2022 | Chinese Journal of Mechanical Engineering2022，35，5： | 1 |
| 12 | Research Progress of Seafloor Pockmarks in Spatio-Temporal Distribution and Classification显示文摘Seafloor pockmarks are important indicators of submarine methane seepages and slope instabilities.In order to promote the understanding of submarine pockmarks and their relationship with sediment instabilities and climate changes,here we summarize the research results of pockmarks in the spatio-temporal distributions and shaping factors.Most of pockmarks occur along active or passive continental margins during the last 25 kyr B.P..Circular and ellipse are the most common forms of pockmarks,whereas pockmarks in a special crescent or elongated shape are indicators of slope instabilities,and ring-shape pockmarks are endemic to the gas hydrate zones.Further researches should be focused on the trigger mechanism of climate changes based on the pockmarks in the high latitudes formed during the deglaciation periods,and the role of gas hydrates in the seafloor evolution should be elucidated.In addition,the feature of pockmarks at their early stage(e.g.,developing gas chimneys and gas driving sedimentary doming)and the relations between pockmarks and mass movements,mud diapirs could be further studied to clarify the influences of rapid methane release from submarine sediments on the atmospheric carbon contents. | XU Cuiling XU Guoqiang XING Junhui SUN Zhilei WU Nengyou | 2020 | Journal of Ocean University of China2020，19，1： | 1 |
| 13 | Serum Ren-alase is related to catecholamine levels and renal func-tion 显示文摘 | Wang Feng Li Junhui Xing Tao | 2015 | Clinical and Experimental Nephrology2015，19，： | 1 |
| 14 | Final-stage Southward Subduction of the Eastern Paleo-Asian Ocean:Evidence from the Middle Permian Mafic Intrusions in the Northern Margin of the North China Craton显示文摘The northern margin of the North China Craton(NCC)contains widespread Permian magmatic rocks,but the origin of these rocks remains controversial.This uncertainty hampers us from better understanding of tectonic framework and evolution of the eastern Paleo-Asian Ocean,particularly with respect to its final-stage subduction and closure time.To address these questions,this study presents petrological,zircon U-Pb geochronological,whole-rock geochemical and in situ zircon Hf isotopic data for these Permian mafic intrusions in the northern margin of the NCC.Precise zircon U-Pb dating results indicate that these mafic intrusions were emplaced in the Middle Permian(ca.260 Ma).Geochemically,the studied mafic intrusions have high MgO and transition metals element contents,with high Mg^(#) values,indicating a mantle origin.These mafic intrusions are characterized by enrichments in large ion lithophile elements(LILEs;e.g.,Rb,Ba,and K)and light rare earth elements(LREEs),and depletions in high field strength elements(HFSEs;e.g.,Nb,Ta,and Ti)and heavy rare earth elements(HREEs),indicating that they were formed in a subduction-related setting.These geochemical features,together with zircon ε_(Hf)(t)values(-1.1 to+11.2),indicate that their parental magmas were derived from partial melting of heterogeneous mantle wedge metasomatized by subduction-related fluids,with the contributions of slab sediments.The studied mafic intrusions also show wide range of major and trace elements contents,and variable Mg^(#) values,Eu and Sr anomalies,suggesting that their parental magmas had undergone variable degrees of fractional crystallization.Together with the E-W trending Permian continental arc along the northern margin of the NCC,we confirm that the generation of the Middle Permian mafic intrusions was related to southward subduction of the Paleo-Asian oceanic lithosphere beneath the NCC and the Paleo-Asian Ocean had not closed prior to the Middle Permian. | JING Yan GE Wenchun DONG Yu YANG Hao JI Zheng BI Junhui ZHOU Hongying XING Dehe | 2022 | Acta Geologica Sinica(English Edition)2022，96，1： | 1 |
| 15 | FreeStand- ing Array of Multi-Walled Carbon Nanotubes on Silicon (111) by a Field-Inducing Self-Assembly Process显示文摘 | Xing Li Xiang Junhui Zhang Fushi | 2010 | Journal of Nanoscience and Nanotechnology2010，10，10： | 1 |
| 16 | Radical Nephrectomy Using a Chevron Incision to Treat Complicated Renal Carcinoma:a Report of 15 Cases显示文摘BJECTIVE To investigate the outcome and indications for radical nephrectomy with a Chevron incision to treat complicated renal carcinoma. METHODS Large renal carcinomas were found in 15 patients during a preoperative CT and/or MRI examination.A tumor thrombus in the renal vein or inferior vena cava was found in 5 cases,and a complication of metastasis in the contralateral adrenal gland was found in 2 patients.All of the 15 patients underwent a radical nephrectomy by a chevron incision and the postoperative pathological results noted. RESULTS Of the 15 patients who underwent a radical nephrectomy and lymphadenectomy,5 also received a thrombectomy,and 2 a contralateral adrenalectomy.All surgical operations were safe and successful.The mean operation time was(4.45±0.83)h,and the intraoperative blood loss was(785±910)ml.All patients recovered well after the surgery.Multimodal therapy was conducted in these cases,with rigorous follow-up. CONCLUSION In determining the type of incision for surgery of renal carcinoma,a chevron incision is suitable for cases with a large tumor,local nodal metastasis,thrombus of the renal vein or inferior vena cava and complicated metastasis to the contralateral adrenal gland.The incision produces a clear operating field with less intra-and post-operative complications. | Ning Kang Junhui Zhang Yinong Niu Nianzeng Xing | 2008 | Chinese Journal of Clinical Oncology2008，5，4： | 0 |
| 17 | The Subduction Structure Beneath the New Britain Island Arc and the Adjacent Region from Double-Difference Tomography显示文摘We applied double-difference tomography to relocate seismic events and determine the lithospheric velocity structure beneath the New Britain Island arc and the South Bismarck Sea Basin,based on the local P wave arrival time dataset collected by the International Seismological Centre.Results of the seismic relocation and velocity inversion show that the subduction of Solomon Sea Plate along the New Britain Trench is spatially different above 150 km,and the subduction angle of the slab on the west side is higher than that on the east side.The relocated earthquakes also show that there are double seismic zones at the depths of about 30–90km beneath the New Britain Island Arc.The velocity structure shows that the dehydration of the subducting slab caused the low-velocity anomalies in mantle wedge above the slab,which are associated with the magmatic activities around the New Guinea-New Britain Island arc.Moreover,it shows that there is another low-velocity anomaly zone beneath the Bismarck mid-oceanic ridge with spatial variation.Beneath the west of the Bismarck mid-oceanic ridge,the low-velocity anomaly is weakly connected to the subducted Solomon Sea slab.Conversely,the low-velocity anomaly beneath the Manus Sea Basin is highly intertwined to the subducting slab and its mantle wedge,indicating that the subduction of the Solomon Sea Plate might be a key deep dynamic factor that drives the spreading of the Manus Sea Basin and the separation of the Bismarck Plate. | ZHANG Hao GONG Wei XING Junhui XU Chong LI Chaoyang | 2023 | Journal of Ocean University of China2023，22，1： | 0 |
| 18 | Hepatic transcriptome signatures in mice and humans with nonalcoholic fatty liver disease显示文摘Background:Nonalcoholic fatty liver disease(NAFLD)is the main reason for cirrhosis and hepatocellular carcinoma.As a starting point for NAFLD,the treatment of nonalcoholic fatty liver(NAFL)is receiving increasing attention.Mice fed a high-fat diet(HFD)and hereditary leptin deficiency(ob/ob)mice are important NAFL animal models.However,the comparison of these mouse models with human NAFL is still unclear.Methods:In this study,HFD-fed mice and ob/ob mice were used as NAFL animal models.Liver histopathological characteristics were compared,and liver transcriptome from both mouse models was performed using RNA sequencing(RNA-seq).RNAseq data obtained from the livers of NAFL patients was downloaded from the GEO database.Global gene expression profiles in the livers were further analyzed using functional enrichment analysis and the Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway.Results:Our results showed that the biochemical parameters of both mouse models and human NAFL were similar.Compared with HFD-fed mice,ob/ob mice were more similar in histologic appearance to NAFL patients.The liver transcriptome characteristics partly overlapped in mice and humans.Furthermore,in the NAFL pathway,most genes showed similar trends in mice and humans,thus demonstrating that both types of mice can be used as models for basic research on NAFL,considering the differences.Conclusion:Our findings show that HFD-fed mice and ob/ob mice can mimic human NAFL partly in pathophysiological process.The comparative analysis of liver transcriptome profile in mouse models and human NAFL presented here provides insights into the molecular characteristics across these NAFL models. | Yiming Ding Xulei Dai Miaoye Bao Yuanming Xing Junhui Liu Sihai Zhao Enqi Liu Zuyi Yuan Liang Bai | 2023 | Animal Models and Experimental Medicine2023，6，4： | 0 |
| 19 | Venoarterial extracorporeal membrane oxygenation in acute myocardial infarction显示文摘IntroductionMortality and complications associated with acute myocardial infarction(AMI)have gradually decreased in the era of reperfusion therapy.However,the outcomes are still poor for AMI patients with severe complications.[1]The quest for further improvement of the use of active mechanical circulatory support(MCS)devices is rapidly evolving.Venoarterial extracorporeal membrane oxygenation(VA-ECMO)is a form of heart-lung bypass that offers temporary mechanical support and simultaneous extracorporeal gas exchange,usually acting as a bridge to recovery.It has been widely used since 1972,after its introduction.Venoarterial extracorporeal membrane oxygenation provides cardiopulmonary support and is used to rescue patients with cardiopulmonary collapse.The use of VA-ECMO after AMI with severe complications is increasing.Recent studies have demonstrated a significant increase in survival using VA-ECMO in patients with AMI,and early VA-ECMO initiation yields better outcomes.This review article is aimed at evaluating the use of VA-ECMO in patients with AMI.[2] | Junhui Xing | 2024 | Emergency and Critical Care Medicine2024，4，1： | 0 |
| 20 | Teleseismic P-Wave Tomography of the New Guinea-Solomon Arc System显示文摘A P-wave tomographic traveltime inversion was applied to obtain a new model of seismic velocity anomalies beneath the New Guinea-Solomon arc system(PN-SL).The P-wave traveltime data,obtained from the revised International Seismological Center catalog,were recorded by 82 seismic stations in the PN-SL.Under the constraints of the epicenter distance,magnitude,and the number of stations recorded,15009 effective P-wave traveltime data were selected from 2011 teleseismic events.The obtained model showed that the Solomon Sea Plate subducted beneath the New Britain Island along the New Britain Trench at an angle of>70°and that the slab can be traced down to a depth of approximately 800 km.Conversely,we cannot observe a high-velocity anomaly exhibited by the subducted Solomon Sea Plate in the deep mantle at the Trobriand Trench,and the slab stopped at a depth of<200 km.The double subduction of the Solomon Sea Plate strongly modified the subduction patterns of the early subducted Pacific and Australian plates in the mantle along the West Melanesian Trench and the Pocklington Trough,respectively.In addition,the subducted Solomon Sea Plate induced the melting of the upper mantle to form a low-velocity anomaly,which provided the deep dynamic source for the expansion of the Bismarck Sea.Based on the joint consideration of the tomography results and a petrological analysis,the low-velocity anomalies beneath the Solomon Sea and Woodlark Basin are closely related to the early subduction of the Pacific and Australian Plates,respectively. | FENG Bing ZHANG Hao GONG Wei XING Junhui LI Deyong XU Chong AN Long | 2022 | Journal of Ocean University of China2022，21，3： | 0 |
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