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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | Effects of luteinizing hormone and androgen on the development of rat progenitor Leydig cells in vitro and in vivo显示文摘祖先 Leydig 房间从干细胞被导出。祖先 Leydig 房间的增长和区别显著地在发身期间贡献 Leydig 房间数字。然而,这些过程的规定仍然保持不清楚。现在的学习的目的是决定 luteinizing 荷尔蒙(LH ) 或雄激素是否贡献祖先 Leydig 房间的增长和区别。Fourteen-day-old 男 Sprague-Dawley 老鼠与 NalGlu 被对待 7 天,它是一个释放 gonadotropin 荷尔蒙对手,到在垂体并且这样减少 LH 的分泌物,在睾丸的雄激素。老鼠与 LH 或 7 α 被共同管理; -methyl-nortestosterone (MENT ) 是对由 5 α 的新陈代谢抵抗的雄激素, -reductase 1 在祖先 Leydig 房间,和 LH 或雄激素的随后的效果被测量。3 H-Thymidine 静脉内地也被注入老鼠在祖先 Leydig 房间学习 thymidine 加入。祖先 Leydig 房间被检验。NalGlu 管理由 83 % 减少了祖先 Leydig 房间增长;。另外, LH 或 MENT 处理恢复了 Leydig 房间 proliferative 能力到 73 %或 50 %控制,分别地。增长相关的基因的送信人 RNA 层次用即时 PCR 被测量。Igf1, Lifr, Pdgfra, Bcl2, Ccnd3 和 Pcna 的表示层次是由 MENT 的 upregulated,并且 Pdgfra, Ccnd3 和 Pcna 的那些是由 LH 的 upregulated。LH 和 MENT 在 vitro 刺激了祖先 Leydig 房间的区别。我们断定 LH 和 MENT 涉及调整祖先 Leydig 房间的发展。 | Jing-Jing Guo Xue Ma Claire Q F Wang Yu-Fei Ge Qing-Quan Lian Dianne O Hard Yu-Fei Zhang Qiang Dong Yun-Fei Xu Ren-Shan Ge | 2013 | Asian Journal of Andrology2013，15，5： | 4 |
| 3 | Thermal and Transmission Properties of UV Nonlinear Optical Material——ZnCd(SCN)_4 Crystal显示文摘Zinc cadmium thiocyanate(ZCTC), ZnCd(SCN) 4, has been discovered as a UV second order nonlinear optical coordination crystal. Its thermal and transmission properties are reported. The thermal decomposition is characterized by using the X ray powder diffraction (XRPD) and infrared (IR) spectroscopy at room temperature. The absorptions of intrinsic ions and ZCTC in a solution state are discussed as well as transmission properties of the ZCTC crystal. An effective method of reducing the surface reflection loss of ZCTC crystal is introduced. | NING H X, XU D, WANG X Q, CHENG X F, YANG Z H (Institute of Cryst. Mater. and State Key Lab. of Cryst. Mater., Shandong University, Jinan 250100, CHN) | 2002 | Semiconductor Photonics and Technology2002，8，1： | 4 |
| 4 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 5 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 6 | 饲料中添加蛋白酶对肉鸡性能、养分利用率、肠道形态和胴体品质的影响显示文摘试验在饲喂玉米、高粱为主的肉鸡日粮中补充大豆,并添加蛋白酶,研究蛋白酶对肉鸡性能、养分消化率、肠道形态和胴体品质的影响。试验选取1日龄AA肉仔鸡(43.8±1.31 g)256只,均为公鸡,随机分配到2×2试验设计方阵中,方阵包括正常组(玉米组和高粱组)和蛋白酶组(空白组和添加蛋白酶150 mg·kg^(-1)的试验组)。试验1~21 d为第一阶段,22~42 d为第二阶段。试验结果表明,第二阶段中,日粮中添加蛋白酶极显著提高肉鸡的平均日增重(ADG,P<0.01),在整个试验过程中显著提高(P<0.05)。在各个时期,正常组对肉鸡生产性能均无显著影响(P>0.05)。19~21 d时,添加蛋白酶可显著提高肉鸡的表观代谢能(AME),干物质(DM)、总能量(GE)和养分消化率(P<0.05)。此外,日粮以高粱为主时,AME、GE消化率有降低趋势(P=0.05),氮沉积率也有降低趋势(P=0.08)。40~42 d时,日粮中添加蛋白酶可显著提高AME,DM、GE和氮沉积率(P<0.05)。21 d时,日粮中添加蛋白酶极显著增加肠绒毛高度、肠绒毛与隐窝深度比值,极显著降低十二指肠、空肠、回肠的隐窝深度(P<0.01)。42 d时,日粮中添加蛋白酶显著增加空肠肠绒毛高度、绒毛高度与隐窝深度比值,显著降低隐窝深度(P<0.05)。日粮中添加蛋白酶显著增加胸肌重、24 h p H,显著降低胸肌的滴水损失(P<0.05)。试验结果表明,饲养阶段日粮中添加复合蛋白酶可提高肉鸡ADG;在第一阶段可改善AME、DM、GE和氮沉积率和肠道形态。补充蛋白酶可提高出栏重、胸肌重和24 h pH,降低胸肌的滴水损失。低单宁高粱日粮与玉米日粮相比,对肉鸡性能的影响相近。 | Xu X Wang H L Pan L Ma X K Tian Q Y Xu Y T Long S F Zhang Z H Piao X S | 2017 | 饲料博览2017，0，1： | 2 |
| 7 | SELECTIVE DIMERIZATION OF BUTANAL TO BUTYL BUTYRATE CATALYZED BY LANTHANOCENE/n-BuLi SYSTEMS显示文摘SELECTIVEDIMERIZATIONOFBUTANALTOBUTYLBUTYRATECATALYZEDBYLANTHANOCENE/n-BuLiSYSTEMS￥FanXU,LiLuZHANG,MingYAO,YuanChenDING,ZhiMi... | Xu, F Zhang, LL Yao, YM Ding, YC Bai, ZM Shen, Q | 1995 | Chinese Chemical Letters1995，6，7： | 2 |
| 8 | 甜菜碱对肥育猪生长激素脉冲释放和血清代谢的影响显示文摘用添加含量为0和0.125%甜菜碱的日粮饲喂肥育猪,试验对杂交肥育猪日粮中甜菜碱对猪的生长性能、生长激素(GH)脉冲释放及血清代谢的影响进行研究。每试验组3个重复,每个重复8头猪(4头去势公猪,4头母猪),试验在饲喂后3h内每15min采集一次血液样本,测定生长激素脉冲释放。结果表明:添加甜菜碱组平均日增重增加5.45%(P〈0.05),而平均日采食量和饲料转化率则不受影响。 | Huang Q C Xu Z R Han X Y Li W F | 2007 | 饲料博览(技术版)2007，，7： | 2 |
| 9 | Syntheses and crystal structures of copper(II) complexes derived from 2,4,6- Tris(2-pyridyl)-1,3,5-triazine显示文摘 | Zheng Y Q Xu W Lin F | 2006 | J Coord Chem2006，59，： | 1 |
| 10 | Alkaline syenites in eastern Cathaysia (South China): Link to Permian-Triassic transtension显示文摘 | Wang Q Li J W Jian P Zhao Z H Xiong X L Bao Z W Xu J F Li C F Ma J L | 2005 | Emth Planet Sci Lett2005，230，34： | 1 |
| 11 | 显示文摘 | Xu L F Guo Y Liao Q | 2005 | Phys Chem B2005，109，13： | 1 |
| 12 | Development of a virus-induced gene-silencing system for functional analysis of the RPS2-dependent resistance signalling pathways in Arabidopsis 显示文摘 | Cai X Z Xu Q F Wang C C | 2006 | Plant Molecular Biology2006，62，12： | 1 |
| 13 | RhoA regulates G1-S progression of gastrie eaneer ealls by modulation of multiple INK4 family tumor suppressors显示文摘 | Zhang S Tang Q Xu F | 2009 | Mol Caneer Res2009，7，4： | 1 |
| 14 | Patterns of cytosine methylation in an elite rice hybrid and its parental lines, detected by a methylation - sensitive amplification polymorphism technique 显示文摘 | Xiong L Z Xu C G Saghai Maroof M A Zhang Q F | 1999 | Molecular and General Genetics1999，261，3： | 1 |
| 15 | Surgical treatment of 40 patients with thoracic ossification of the ligamentum flavum显示文摘 | Li F Chen Q Xu K | 2006 | J Neurosurg Spine2006，4，3： | 1 |
| 16 | Investigation of candidate VRM topologies for future microprocessors显示文摘 | Zhou X Wong P Xu P Lee F C Huang A Q | 2000 | IEEE Transactions on Power Electronics2000，15，6： | 1 |
| 17 | Assembly of a supramolecular cube, from a preformed incomplete cubane-like compound 显示文摘 | Lamg J P Xu Q F Chen Z N | 2003 | J Am Chem Soc2003，125，12： | 1 |
| 18 | Time-domain modeling of high-speed interconnects by modified method of characteristics显示文摘 | Q Xu Z F Li P Mazumder J F Mao | 2000 | IEEE Trans Microwave Theory and Tech2000，48，2： | 1 |
| 19 | Circulating progenitor cells regenerate endothelium of vein graft atherosclerosis, which is diminished in ApoE-deficient mice 显示文摘 | Xu Q Zhang Z Davison F | 2003 | Circ Res2003，93，8： | 1 |
| 20 | Triassic volcanism in eastern Heilongjiang and Jilin provinces, NE China: chronology, geochemistry, and tectonic implications显示文摘 | Xu W L Ji w Q Pei F P | 2009 | Journal of Asian Earth Sciences2009，34，： | 1 |
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