|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | China Stroke Statistics 2019:A Report From the National Center for Healthcare Quality Management in Neurological Diseases,China National Clinical Research Center for Neurological Diseases,the Chinese Stroke Association,National Center for Chronic and Non-communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations显示文摘China faces the greatest challenge from stroke in the world.The death rate for cerebrovascular diseases in China was 149.49 per 100000,accounting for 1.57 million deaths in 2018.It ranked third among the leading causes of death behind malignant tumours and heart disease.The age-standardised prevalence and incidence of stroke in 2013 were 1114.8 per 100000 population and 246.8 per 100000 person-years,respectively.According to the Global Burden of Disease Study 2017,the years of life lost(YLLs)per 100000 population for stroke increased by 14.6%;YLLs due to stroke rose from third highest among all causes in 1990 to the highest in 2017.The absolute numbers and rates per 100000 population for all-age disability-adjusted life years(DALYs)for stroke increased substantially between 1990 and 2017,and stroke was the leading cause of all-age DALYs in 2017.The main contributors to cerebrovascular diseases include behavioural risk factors(smoking and alcohol use)and pre-existing conditions(hypertension,diabetes mellitus,dyslipidaemia and atrial fibrillation(AF)).The most prevalent risk factors among stroke survivors were hypertension(63.0%-84.2%)and smoking(31.7%-47.6%).The least prevalent was AF(2.7%-7.4%).The prevalences for major risk factors for stroke are high and most have increased over time.Based on the latest national epidemiological data,26.6%of adults aged≥15 years(307.6 million adults)smoked tobacco products.For those aged≥18 years,age-adjusted prevalence of hypertension was 25.2%;adjusted prevalence of hypercholesterolaemia was 5.8%;and the standardised prevalence of diabetes was 10.9%.For those aged≥40 years,the standardised prevalence of AF was 2.31%.Data from the Hospital Quality Monitoring System showed that 3010204 inpatients with stroke were admitted to 1853 tertiary care hospitals during 2018.Of those,2466785(81.9%)were ischaemic strokes(ISs);447609(14.9%)were intracerebral haemorrhages(ICHs);and 95810(3.2%)were subarachnoid haemorrhages(SAHs).The average age of patients admitted was 66 years old,and nearly 60%were male.A total of 1555(0.1%),2774(0.6%)and 1347(1.4%)paediatric strokes(age<18 years)were identified among IS,ICH and SAH,respectively.Over one-third(1063892(35.3%))of the patients were covered by urban resident basic medical insurance,followed by urban employee basic medical insurance(699513(23.2%))and new rural cooperative medical schema(489361(16.3%)).The leading risk factor was hypertension(67.4%for IS,77.2%for ICH and 49.1%for SAH),and the leading comorbidity was pneumonia or pulmonary infection(10.1%for IS,31.4%for ICH and 25.2%for SAH).In-hospital death/discharge against medical advice rate was 8.3%for stroke inpatients,ranging from 5.8%for IS to 19.5%for ICH.The median and IQR of length of stay was 10.0(7.0-14.0)days,ranging from 10.0(7.0-13.0)in IS to 14.0(8.0-22.0)in SAH.Data from the Chinese Stroke Center Alliance demonstrated that the composite scores of guideline-recommended key performance indicators for patients with IS,ICH and SAH were 0.77±0.21,0.72±0.28 and 0.59±0.32,respectively. | Yong-Jun Wang Zi-Xiao Li Hong-Qiu Gu Yi Zhai Yong Jiang Xing-Quan Zhao Yi-Long Wang Xin Yang Chun-Juan Wang Xia Meng Hao Li Li-Ping Liu Jing Jing Jing Wu An-Ding Xu Qiang Dong David Wang Ji-Zong Zhao On behalf of China Stroke Statistics 2019 Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 181 |
| 2 | New eolian red clay sequence on the western Chinese Loess Plateau linked to onset of Asian desertification about 25 Ma ago显示文摘The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, is a contentious topic in paleoclimatology. Late Cenozoic eolian loess-red clay sequences on the Chinese Loess Plateau, which possess abundant paleoclimatic and paleo-environmental information, can be regarded as an indicator of inland Asia desertification. Here we present a detailed magnetostratigraphic investigation of a new red clay sequence about 654 m in Zhuanglang located at the western Chinese Loess Plateau. Sedimentological, geochemical, mineralogical, and quartz morphological lines of evidence show that the red clay is of eolian origin. Magnetostratigraphic correlations indicate that this core sequence spans from 25.6 to 4.8 Ma, and typical eolian red clay appears as early as 25 Ma. This extends the lower limit of the red clay on the Chinese Loess Plateau from the previously thought early Miocene back into the late Oligocene. This new red clay record further implies that the inland Asia desertification was initiated at least by the late Oligocene. This sequence provides a unique high-resolution geological record for understanding the inland Asia desertification process since the late Oligocene. | QIANG XiaoKe AN ZhiSheng SONG YouGui CHANG Hong SUN YouBin LIU WeiGuo AO Hong DONG JiBao FU ChaoFeng WU Feng LU FengYan CAI YanJun ZHOU WeiJian CAO JunJi XU XinWen AI Li | 2011 | Science China Earth Sciences2011，54，1： | 73 |
| 3 | Artificial intelligence in healthcare:past,present and future显示文摘Artificial intelligence(AI)aims to mimic human cognitive functions.It is bringing a paradigm shift to healthcare,powered by increasing availability of healthcare data and rapid progress of analytics techniques.We survey the current status of AI applications in healthcare and discuss its future.AI can be applied to various types of healthcare data(structured and unstructured).Popular AI techniques include machine learning methods for structured data,such as the classical support vector machine and neural network,and the modern deep learning,as well as natural language processing for unstructured data.Major disease areas that use AI tools include cancer,neurology and cardiology.We then review in more details the AI applications in stroke,in the three major areas of early detection and diagnosis,treatment,as well as outcome prediction and prognosis evaluation.We conclude with discussion about pioneer AI systems,such as IBM Watson,and hurdles for real-life deployment of AI. | Fei Jiang Yong Jiang Hui Zhi Yi Dong Hao Li Sufeng Ma Yilong Wang Qiang Dong Haipeng Shen Yongjun Wang | 2017 | Stroke & Vascular Neurology2017，2，4： | 76 |
| 4 | The Chinese Stroke Association scientific statement:intravenous thrombolysis in acute ischaemic stroke显示文摘The most effective medical treatment for acute ischaemic stroke(AIS)is to offer intravenous thrombolysis during the ultra-early period of time after the onset.Even based on the Consensus of Chinese Experts on Intravenous Thrombolysis for AIS in 2012 and 2014 Chinese Guidelines on the Diagnosis and Treatment of AIS,the rate of thrombolysis for AIS in China remained around 2.4%,and the rate of intravenous tissue plasminogen activator usage was only about 1.6%in real world.The indication of thrombolysis for AIS has been expanded,and contraindications have been reduced with recently published studies.In order to facilitate the standardisation of treating AIS,improve the rate of thrombolysis and benefit patients who had a stroke,Chinese Stroke Association has organised and developed this scientific statement. | Qiang Dong Yi Dong Liping Liu Anding Xu Yusheng Zhang Huaguang Zheng Yongjun Wang 无 | 2017 | Stroke & Vascular Neurology2017，2，3： | 56 |
| 5 | Jurassic Tectonic Revolution in China and New Interpretation of the “Yanshan Movement”显示文摘摘要:与结构的地质的调查的新数据和高分辨率的同位素的标明日期数据的获得和累积,我们极大地改进了我们从迟了的侏罗记在时期期间发生在东方中国到早白垩纪的构造事件的理解并且可以给性质的新解释,预定并且 Yanshan 运动的 geodynamic 背景。在中间迟了的侏罗记期间(165 挠慬獳漠 ?? | DONG Shuwen ZHANG Yueqiao LONG Changxing YANG Zhenyu JI Qiang WANG Tao HU Jianmin CHEN Xuanhua | 2008 | Acta Geologica Sinica(English Edition)2008，82，2： | 41 |
| 6 | The Association of Overweight and Obesity with Blood Pressure among Chinese Children and Adolescents显示文摘Objective To examine the association between obesity and high blood pressure (BP) in Chinese children and adolescents. Methods Body mass index (BMI) and blood pressure measurements of 197 191 children aged 7-17 years were obtained from a Chinese national survey in 2010. Obesity and high BP were defined according to the reference values for Chinese children. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of different BMI categories for high BP, as well as the population attributable risk percent (PAR%), were also calculated. Results The prevalence of high BP was 16.1% for boys and 12.9% for girls in 2010. Overweight and obese children had a significantly higher prevalence of high BP than non-overweight children in both boys and girls in each age group. ORs (95% CI) for high BP were 4.1 (3.9, 4.4) in obese boys and 4.0 (3.7, 4.3) in obese girls. The overall PAR% for high BP due to overweight and obesity was 14.4%. Conclusion Overweight and obese children have a significantly higher risk of high BP than non-overweight children. Eliminating overweight and obesity could reduce 14.4% of high BP cases. | DONG Bin MA Jun WANG Hai Jun WANG Zhi Qiang | 2013 | Biomedical and Environmental Sciences2013，26，6： | 42 |
| 7 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 8 | Effect of artificial aeration on the performance of vertical-flow constructed wetland treating heavily polluted river water显示文摘Three lab-scale vertical-flow constructed wetlands(VFCWs),including the non-aerated(NA),intermittently aerated(IA) and continuously aerated(CA) ones,were operated at different hydraulic loading rates(HLRs) to evaluate the effect of artificial aeration on the treatment efficiency of heavily polluted river water.Results indicated that artificial aeration increased the dissolved oxygen(DO) concentrations in IA and CA,which significantly favored the removal of organic matter and NH 4 +-N.The DO grads caused by intermittent aeration formed aerobic and anoxic regions in IA and thus promoted the removal of total nitrogen(TN).Although the removal efficiencies of COD Cr,NH 4 +-N and TN in the three VFCWs all decreased with an increase in HLR,artificial aeration enhanced the reactor resistance to the fluctuation of pollutant loadings.The maximal removal efficiencies of COD Cr,NH 4 +-N and total phosphorus(TP)(i.e.,81%,87% and 37%,respectively) were observed in CA at 19 cm/day HLR,while the maximal TN removal(i.e.,57%) was achieved in IA.Although the improvement of artificial aeration on TP removal was limited,this study has demonstrated the feasibility of applying artificial aeration to VFCWs treating polluted river water,particularly at a high HLR. | Huiyu Dong Zhimin Qiang Tinggang Li Hui Jin Weidong Chen | 2012 | Journal of Environmental Sciences2012，24，4： | 38 |
| 9 | Limbic Encephalitis Associated with Anti-y-aminobutyric Acid B Receptor Antibodies: A Case Series from China显示文摘 | Hong-Zhi Guan Hai-Tao Ren Xun-Zhe Yang Qiang Lu Bin Peng Yi-Cheng Zhu Xiao-Qiu Shao Yong-Qiang Hu Dong Zhou Li-Ying Cui | 2015 | Chinese Medical Journal2015，，22： | 38 |
| 10 | Chinese Stroke Center Alliance:a national effort to improve healthcare quality for acute stroke and transient ischaemic attack:rationale,design and preliminary findings显示文摘Background In June 2015,the Chinese Stroke Association(CSA)initiated the Chinese Stroke Center Alliance(CSCA)to establish the national hospital-based stroke care quality assessment and improvement platform.This article outlines its objectives,operational structure,patient population,quality improvement(QI)intervention tools,data elements,data collection methodology and current patient and hospital data.Methods The CSCA is a national,hospital-based,multicentre,voluntary,multifaceted intervention and continuous QI initiative.This multifaceted intervention includes stroke centre development,written care protocols,workshops and a monitoring/feedback system of evidencebased performance measures.The data coordinating centre of the CSCA resides at the China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital.results As of July 2017,1576 hospitals in China have contributed detailed clinical information to serve as a benchmark for the stroke care quality of 433264 patients with acute stroke/transient ischaemic attacks(TIA),including 352572(81.38%)acute ischaemic stroke,30362(7.01%)TIA,42080(9.71%)spontaneous intracranial haemorrhage,5505(1.27%)subarachnoid haemorrhage and 2745(0.63%)not specified stroke.Conclusion The CSCA programme is designed to establish a continuous national stroke registry and help healthcare providers develop stroke centres and treat patients in a consistent manner in accordance with accepted national guidelines and,ultimately,improve patient outcomes.It supports the CSA mission to reduce stroke burden in China. | Yongjun Wang Zixiao Li Yilong Wang Xingquan Zhao Liping Liu Xin Yang Caiyun Wang Hongqiu Gu Fuying Zhang Chunjuan Wang Ying Xian David Z Wang Qiang Dong Anding Xu Jizong Zhao Chinese Stroke Center Alliance investigators | 2018 | Stroke & Vascular Neurology2018，3，4： | 38 |
| 11 | Differentiation profile of brain tumor stem cells:a comparative study with neural stem cells显示文摘大脑肿瘤干细胞(BTSC ) 的区别侧面的理解,在肿瘤房间人口之中的关键的,将通过有神经干细胞(NSC ) 的比较借卓见进 glioma 的起源并且最终产出新途径与这难处理的疾病作斗争。这里,我们从外科的 glioma 标本的有教养、净化的 BTSC 和 NSCsfrom 人的胎儿的大脑织物,并且进一步分析了他们的细胞的生物行为,他们的特别区别性质。是期望,区分进成熟神经显型的 NSC。然而, BTSC 展出了的 Inthe 一样的区别状况区分了差别。词法上,房间变得变平并且属于第一个星期,但是逐渐地此后聚集了并且改过漂浮的肿瘤范围。在相应时期期间,无差别的房间标记 CD133 和巢在的表示率在 BTSC 不停地减少,但是 1 个星期以后,他们重获上升趋势。有趣地,区分的房间标记 GFAP 和 beta-tubulinIIIshowed 表示变化逆到无差别的房间标记的。总起来说, BTSCswere 揭示了拥有一个能力抵抗区别,它实际上代表 glioma 的恶意的行为。 | Quan Bin Zhang Xiao Yan Ji Qiang Huang Jun Dong Yu De Zhu Qing Lan | 2006 | Cell Research2006，16，12： | 34 |
| 12 | Therapy and prognostic features of primary clear cell carcinoma of the liver显示文摘AIM:To clarify the therapeutic strategies and prognosis factors of primary clear cell carcinoma of the liver(PCCCL) . METHODS:The clinical pathological data of 64 patients with PCCCL treated with hepatectomy in our hospital from January 2000 to January 2006 were analyzed retrospectively.The patients were divided into two groups to make treatment analysis:curative resection only(n=40) ;and curative resection and postoperative chemotherapy with calcium folinate and tegafur(n= 24) .Meanwhile,the PCCCL patients were subdivided into two subgroups on the basis of the proportion of clear cells in the tumor for pathological analysis.There were 36 cases in subgroup A for which the proportion of clear cells was more than 70%,and 28 cases in subgroup B for which the proportion was less or equal to 70%,comparing analysis of median survival time of the counterpart groups.Univariate and multivariate analyses were performed to examine factors that affect-ed clinical prognosis,recurrence and metastasis. RESULTS:Median survival period of the curative surgery group was 38 mo,while the counterpart was 41 mo.Median survival period for group A was 41 mo,while group B was 19 mo.The Kaplan-Meier method showed that capsule formation,preoperative liver function,hepatitis C virus infection,large vascular invasion and multiple tumor occurrences were related to disease-free survival.Cox regression analysis showed that the clear cell ratio,capsule formation,preoperative liver function and large vascular invasion were independent risk factors for overall survival. CONCLUSION:Postoperative chemotherapy has no obvious effect on survival of patients with PCCCL. Clear cell ratio,capsule formation,preoperative liver function,and vascular invasion were independent risk factors for prognosis. | Ji, Sheng-Pu Li, Qiang Dong, Hui | 2010 | World Journal of Gastroenterology2010，16，6： | 28 |
| 13 | Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin显示文摘LRP16 以前在乳癌房间作为导致雌激素的基因被识别。到在子宫内膜的癌症(EC ) 的雌激素和它的功能的效果的 LRP16 的应答的海角房间仍然是不清楚的。这里,我们证明 LRP16 基因的信使 rna 水平和倡导者活动被 17beta-estradiol (E2 ) 显著地在雌激素受体高山增加哈(嗯高山哈)-positiveIshikawa 人 EC 房间。尽管 Ishikawa 细胞的生长率没被 LRP16 的宫外的表示显然影响, Transwell 试金的结果显示出 LRP16-overexpressing 细胞的侵略能力的近似 one-thirdincrease。由于分子的屏蔽,我们观察到 E-cadherin 的表示,与肿瘤转移联系的一个必要粘附分子,被 LRP16 镇压。进一步的倡导者分析以一种剂量依赖者方式表明了那 LRP16 inhibitedE-cadherin transactivation。然而,抑制被雌激素剥夺废除,显示由 LRP16requires 的 E-cadherin 抄写的 down 规定嗯高山哈调停。染色质免疫降水分析表明到 E-cadherin 倡导者的 ERalpha 的绑定被 LRP16 反对,建议那 LRP16 能防碍嗯调停 alpha 的抄写。这些结果建议起来由雌激素的 LRP16 的规定能被在人的 EC 调整 E-cadherin 的 down 涉及侵略生长。 | Yuan Guang Meng Wei Dong Han Ya Li Zhao Ke Huang Yi Ling Si Zhi Qiang Wu Yi Ming Mu | 2007 | Cell Research2007，17，10： | 27 |
| 14 | Late Miocene Red River submarine fan,northwestern South China Sea显示文摘A huge submarine fan is discovered through the research of the seismic and borehole data in the binding site of Yinggehai basin and Qiongdongnan basin in northwestern South China Sea.The fan,mainly formed during Late Miocene (Huangliu period) has an area over 10000 km 2 and maximum thickness of over 2000 m.It is characterized by a wedge-shaped oblique progradation configuration on the dip profile and a hummocky bidirectional progradation configuration on the strike profile.The core and Logging data from the well YC35-1-2 located in the front side of the fan indicate that sandy gravity flow deposits are predominant in lower Huangliu Formation and change to interbeds of sand and mud in upper Huangliu Formation.The fan is interpreted as a sand/mud-rich submarine fan in combination with the bathyal geological background of Huangliu period.A preliminary analysis of provenance indicates that neither the Guiren Uplift in the west nor the Hainan Uplift in the north can serve as the major provenance for the submarine fan.The provenance is considered to be from the Red River,based on the sedimentary facies study of the Huangliu Formation in Yinggehai basin.The fan is thus named as 'Red River submarine fan'.The Red River depositional system consists of the Red River submarine fan,the Red River delta,and associated submarine canyons.The discovery of the Red River submarine fan provides important information for the research of the uplift of Tibetan Plateau and the evolvement of Red River Fault Zone.Furthermore,it also points out a new direction for the deepwater hydrocarbon exploration in the northern South China Sea. | WANG YingMin XU Qiang LI Dong HAN JianHui LU Ming WANG YongFeng LI WeiGuo WANG HaiRong | 2011 | Chinese Science Bulletin2011，56，14： | 28 |
| 15 | Angiotensin-converting enzyme 2 activation protects against pulmonary arterial hypertension through improving early endothelial function and mediating cytokines levels显示文摘 | LI Gang XU Yu-lin LING Feng LIU Ai-jun WANG Dong WANG Qiang LIU Ying-long | 2012 | Chinese Medical Journal2012，，8： | 24 |
| 16 | Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell proliferation by up-regulation of p27^kipl via the ERK signal pathway显示文摘背景 RhoA/ Rho kinase (岩石) 小径涉及肺的动脉的高血压(哼) 并且肺的动脉光滑的肌肉房间(PASMC ) 增长。岩石的抑制作为一个处理被建议了为哼。但是 RhoA/ROCK 小径并且它在人的 PASMC 的增长的下游的发信号的机制是不清楚的。我们调查了 fasudil 的效果,一个选择岩石禁止者,在导出血小板的生长上,因素( PDGF )导致了人的 PASMC 增长,和在 RhoA/ROCK 和细胞外的调整信号的 kinase (英皇家空军之阶级最低之兵)之间的可能的协会, p27KiP1.Methods 人 PASMC 与 10 ng/ml PDGF 的刺激是有教养的,并且 fasudil 的不同集中在 mitogen 的增加前被增加。房间生存能力和房间周期分别地与 MTT 和流动 cytometry 被决定。岩石活动,英皇家空军之阶级最低之兵活动和增殖的房间的蛋白质表示原子 angigen (PCNA ) 和 p27Kip1 被 MTT 试金被 immunoblotting.Results 测量, PDGF 显著地增加了代表了人的 PASMC 增长的 OD 值,并且有 fasudil 的预告的处理显著地颠倒了以一种剂量依赖者方式的这效果。在 PDGF 刺激以后,在 S 阶段的房间的百分比从 15.6 ~ 24.3 戏剧性地增加了,当在 G0/G1 阶段的百分比从 80.6 ~ 59 被减少时。并且有 fasudil 的预告的处理以一种剂量依赖者方式显著地颠倒了 PDGF 的房间周期效果。PDGF 显著地在 15 分钟与一座山峰导致了岩石活动和英皇家空军之阶级最低之兵活动,它被 fasudil 显著地禁止。另外, fasudil 显著地也禁止了导致 PDGF 的 PCNA 表示和 fasudil 在人的 PASMC 的 upregulated p27Kip1 表示,在 PDGF stimulation.Conclusion RhoA/ROCK 为导致 PDFG 的人的 PASMC 增长是重要的以后,它减少了,和 fasudil 有效地由 p27Kip1 的起来规定禁止了导致 PDGF 的人的 PASMC 增长,它可以与英皇家空军之阶级最低之兵的抑制被联系活动。 | LIU Ai-jun LING Feng WANG Dong WANG Qiang LU Xiao-dong LIU Ying-long | 2011 | Chinese Medical Journal2011，，19： | 23 |
| 17 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 18 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 19 | Adsorption of graphene oxide/chitosan porous materials for metal ions显示文摘多孔的 graphene oxide/chitosan (PGOC ) 材料被一个单向性的 freeze-drying 方法准备。他们为金属离子的多孔的结构,机械性质和吸附被调查。结果证明 graphene 氧化物的加入(去) 显著地增加了 PGOC 材料的压缩力量。当时, Pb2+ 的浸透的吸附能力增加了大约 31% ,直到 99 mg/g 5 wt% 去被合并这些可被细菌破坏的、无毒的、有效 PGOC 材料将是为在水的答案的金属离子的潜在的吸附物。 | Yong Qiang He Na Na Zhang Xiao Dong Wang | 2011 | Chinese Chemical Letters2011，22，7： | 20 |
| 20 | History and possible mechanisms of prehistoric human migration to the Tibetan Plateau显示文摘Prehistoric human history on the Tibetan Plateau is a hotly debated topic. Archaeological research on the plateau during the past few decades has enormously improved our understanding of the topic and makes it possible for us to consider the processes and mechanisms of prehistoric human migration to the region. By reviewing the published archaeological research on the Tibetan Plateau, we propose that the first people on the plateau initially spread into the He-Huang region from the Chinese Loess Plateau, and then moved to the low elevation Northeastern Tibetan Plateau and perhaps subsequently to the entire plateau. This process consisted of four stages.(1) During the climatic amelioration of the Last Deglacial period(15–11.6 ka BP), Upper Paleolithic hunter-gatherers with a developed microlithic technology first spread into the Northeastern Tibetan Plateau.(2) In the early-mid Holocene(11.6–6 ka BP), Epipaleolithic microlithic hunter-gatherers were widely distributed on the northeastern plateau and spread southwards to the interior plateau, possibly with millet agriculture developed in the neighboring low elevation regions.(3) In the mid-late Holocene(6–4 ka BP), Neolithic millet farmers spread into low elevation river valleys in the northeastern and southeastern plateau areas.(4) In the late Holocene(4–2.3 ka BP), Bronze Age barley and wheat farmers further settled on the high elevation regions of the Tibetan Plateau, especially after 3.6 ka BP. Finally, we suggest that all of the reported Paleolithic sites earlier than the LGM on the Tibetan Plateau need further examination. | ZHANG DongJu DONG GuangHui WANG Hui REN XiaoYan HA PiPu'u QIANG MingRui CHEN FaHui | 2016 | Science China Earth Sciences2016，59，9： | 20 |
您所在的机构暂未开通此部分的功能，请联系管理员