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| 1 | 感染模型家兔体内莫西沙星的药动学显示文摘目的 :研究莫西沙星在感染家兔模型中的药物动力学。方法 :8只家兔经埴入高尔夫练习球并用肺炎链球菌感染 3d后 ,用多剂量口服莫西沙星治疗 ,第 5天进行药动学试验。用高效液相色谱法测定血药浓度。结果 :莫西沙星在家兔体内属线性药物并符合二房室模型 ;达峰时间为 (1.2± 0 .6)h ,峰浓度为 (13 .2± 4 .0 ) μg·ml-1,曲线下面积为 (86.5± 2 1.1) μg·ml-1·h ,消除半衰期为 (13 .0± 6.2 )h。 4只家兔高尔夫练习球内的莫西沙星血清峰浓度 ,在为 3 .6± 2 .1μg·ml-12 4h内的平均曲线下面积为 (65 .4± 2 1.1) μg·ml-1·h。结论 :获得的莫西沙星在家兔模型中的药动学参数 ,对今后莫西沙星的药效学研究有很大的帮助。 | 钟明康 Xuan D Nicolau DP Nightingale CH2 | 2001 | 中国医院药学杂志2001，21，1： | 10 |
| 2 | Adaptive response surface method based on a double weighted regression technique显示文摘 | Xuan Son Nguyen Alain Sellier Frédéric Duprat Gérard Pons | 2008 | Probabilistic Engineering Mechanics2008，，2： | 2 |
| 3 | Effects of application of alfalfa pellet on germination and growth of weeds显示文摘 | XUAN T D TSUZUKI E | 2001 | Journal of Crop Production2001，4，2： | 1 |
| 4 | Real--time Liquid--erys-tal Atmosphere Turbulence Simulator with Graphic Processing Unit显示文摘 | Hu L Xuan L Li D | 2009 | Optics Express2009，17，9： | 1 |
| 5 | Mixture optimization of cement treated demolition waste with recycled masonry and concrete显示文摘 | Xuan D X Houben L J M Molenaar A A A | 2012 | Materials and structures2012，45，12： | 1 |
| 6 | Distortionless data hiding based on integer wavelet transform显示文摘 | Xuan G R Zhu J Chen J D | 2002 | IEE Electronics Letters2002，38，25： | 1 |
| 7 | Laboratory Assessment of Emission Reduction Strategies for the Agricultural Fumigants 1,3-Dichloropropene and Chl0ropicrin显示文摘 | ASHWORTH D J ERNST F F XUAN Ri-cheng | 2009 | Environ Sci Technol2009，43，13： | 1 |
| 8 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 9 | Optimization of a combined thermionic–thermoelectric generator显示文摘 | X.C Xuan D Li | 2002 | Journal of Power Sources2002，，1： | 1 |
| 10 | Weed control with alfalfa pellet in transplanting in rice显示文摘 | XUAN T D TSUZUKI E UEMATSU H | 2001 | Weed Biology and Management2001，1，： | 1 |
| 11 | Mass transport in laser surface nitriding involving the effect of high temperature gradi- ent:Simulation and experiment 显示文摘 | Xuan F Z Cao L Q Wang Z D | 2010 | Computational Materials Science2010，49，1： | 1 |
| 12 | C * estimation for cracks in mismatched welds and finite element validation 显示文摘 | XUAN F Z TU S T WANG Z D | 2004 | International Journal of Fracture2004，126，： | 1 |
| 13 | Distributions of polycyclic aromatic hydrocarbons in surface waters, sediments and soils of Hangzhou City, China显示文摘 | Chen B L Xuan X D Zhu L Z | 2004 | Wat Res2004，38，： | 1 |
| 14 | Anodic stripping voltammetry of arsenic using gold nanoparticle - modified electrodes 显示文摘 | Xuan D Olga N Michael E H | 2004 | Anal Chem2004，76，： | 1 |
| 15 | A routing protocol for anycast messages显示文摘 | Xuan D Jia W J Zhao W | 2000 | IEEE Transactions on Parallel and Distributed Systems2000，11，6： | 1 |
| 16 | An improved NURBS-basedisogeometric analysis with enhanced treatment of essentialboundary conditions显示文摘 | Wang D D Xuan J C | 2010 | Computer Methods in AppliedMechanics and Engineering2010，199，24： | 1 |
| 17 | Rehydration reactivity of recycled mortar from concretewaste experienced to thermal treatment显示文摘 | SHUI Z H XUAN D X WAN H W | 2008 | Constructionand Building Materials2008，22，8： | 1 |
| 18 | Using quality scores and longer reads improves accuracy of Solexa read mapping显示文摘 | SMITH A D XUAN Z ZHANG M Q | 2008 | BMC Bioinformatics2008，9，1： | 1 |
| 19 | Optimal patterns for four-connectivity and full coverage in wireless sensor networks 显示文摘 | BaiX L Yun Z Q Xuan D | 2010 | IEEE Transactions on Mobile Computing2010，9，3： | 1 |
| 20 | Distributed admission control for anycast flows显示文摘 | Jia W J Xuan D Tu W Q | 2004 | IEEE Transactions on Parallel and Distributed Systems2004，15，8： | 1 |
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