|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Survival difference between EGFR Del19 and L858R mutant advanced non-small cell lung cancer patients receiving gefitinib:a propensity score matching analysis显示文摘Objective: Although superior clinical benefits of epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors(TKIs) in the treatment of advanced non-small-cell lung cancer(NSCLC) had been reported,the survival difference between exon 19 deletion(Del19) and exon 21 Leu858 Arg substitution(L858 R) remains controversial.The purpose of this study is to investigate the differences in progression-free survival(PFS) and overall survival(OS) between different EGFR mutant subtypes among advanced NSCLC patients receiving gefitinib.Methods: There were 204 advanced NSCLC patients with EGFR mutations treated with gefitinib were enrolled in this retrospective cohort study.Patients were divided into the EGFR Del19 group and the L858 R mutated group according to their mutant subtype.Propensity score matching(PSM) was conducted by using a nearest-neighbor algorithm(1:1) to adjust for demographical and clinical covariates.Survival curves were constructed with the Kaplan-Meier method and compared by using the log-rank test.Results: The PFS in Del19 group was similar to that in the L858 R group [before PSM 8.6 vs.7.2 months,P=0.072; after PSM 7.3 vs.7.2 months,P=0.155].No differences were detected in OS between the L858 R and the Del19 group(before PSM 17.8 vs.13.1 months,P=0.253; after PSM 16.9 vs.13.1 months,P=0.339).The Del19 group was significantly younger compared with the L858 R mutation group in age(P=0.015).Conclusions: No significant difference was found in the PFS or OS between the Del19 and L858 R mutant NSCLC patients receiving gefitinib.The age gap might contribute to the survival differences between Del19 and L858 R groups.PSM is of important value to the elimination of potential bias. | Minglei Zhuo Qiwen Zheng Jun Zhao Meina Wu Tongtong An Yuyan Wang Jianjie Li Shuhang Wang Jia Zhong Xue Yang Hanxiao Chen Bo Jia Zhi Dong Emei Gao JingjingWang Ziping Wang | 2017 | Chinese Journal of Cancer Research2017，29，6： | 4 |
| 2 | Antioxidantactivity and total phenolic contentsin peel and pulp of Chinese jujube{Ziziphus Jujuba Mill) fruits 显示文摘 | XUE Ziping FENG Weihua CAO Jiankang | 2009 | Journal of Food Biochemistry2009，33，5： | 1 |
| 3 | Antioxidant activity and total phenolic contents in peel and pulp of Chinese jujube (Ziziphus Jujuba Mill) Fruits显示文摘 | XUE Ziping FENG Weihua CAO Jiankang | 2009 | Journal of Food Biochemistry2009，33，5： | 1 |
| 4 | Antioxidant Activity And Total Phenolic Contents In Peel And Pulp Of Chinese Jujube (Ziziphus Jujuba Mill) Fruits显示文摘 | Ziping Xue Weihua Feng Jiankang Cao | 2009 | Journal of Food Biochemistry2009，33，5： | 1 |
| 5 | Antioxidant activity and total phenolic contents in peel and pulp of chinese jujube (Ziziphus jujuba mill) fruits显示文摘 | XUE Ziping FENG Weihua CAO Jiankang | 2009 | Journal of Food Biochemistry2009，33，5： | 1 |
| 6 | Antioxidant acticity and total phenolic contents in peel and pulp of Chinese jujube (Ziziphusjujuba Mill) fruits显示文摘 | XUE ZIPING FENG WEIHUA CAO JIANKANG | 2009 | Journal of Food Biochemistry2009，，33： | 1 |
| 7 | Antioxidant acticity and total phenolic contents in peel and pulp of Chinese jujube (Ziziphus jujuba MilL) fruits显示文摘 | XUE Ziping FENG Weihua CAO Jiankang | 2009 | Journal of Food Biochemistry2009，33，5： | 1 |
| 8 | Single-pulse Emission Variation of Two Pulsars Discovered by FAST显示文摘We investigate the single-pulse emission variations of two pulsars,PSRs J0211+4235 and J0553+4111,observed with the Five-hundred-meter Aperture Spherical radio Telescope at the 1.25 GHz central frequency.The observation sessions span from 2020 December to 2021 July,with 21 and 22 observations for them respectively.The integrated pulse profile of PSR J0211+4235 shows that there is a weak pulse component following the main component,and PSR J0553+4111 displays a bimodal profile with a bridge component in the middle.PSR J0211+4235 presents significant nulling phenomenon with nulling duration lasting from 2 to 115 pulses and burst duration lasting from 2 to 113 pulses.The NF of each observation is determined to be 45%-55%.No emission greater than threeσis found in the mean integrated profile of all nulling pulses.In most cases,the pulse energy changes abruptly during the transition from null to burst,while in the transition from burst to null there are two trends:abrupt and gradual.We find that the nulling phenomenon of PSR J0211+4235 is periodic by the Fourier transform of the null and burst state.In addition,the single-pulse modulation characteristics of these two pulsars are investigated,and the distributions of modulation index,LRFS and 2DFS are analyzed with PSRSALSA.The left peak of PSR J0553+4111 has intensity modulation.Finally,the polarization properties of these two pulsars are obtained through polarization calibration,and their characteristics are analyzed.The possible physical mechanisms of these phenomena are discussed. | Ziping Guo Zhigang Wen Jianping Yuan Feifei Kou Qingdong Wu Na Wang Weiwei Zhu Di Li Mengyao Xue Pei Wang Chenchen Miao De Zhao Yue Hu Wenming Yan Jiarui Niu Rukiye Rejep Zhipeng Huang | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员