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您的检索式：作者名="Xia Fuquan"
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| 1 | Alisol B 23-acetate-induced HepG2 hepatoma cell death through mTOR signaling-initiated G_1 cell cycle arrest and apoptosis: A quantitative proteomic study显示文摘Objective: The present study aimed to investigate the molecular events in alisol B 23-acetate(ABA) cytotoxic activity against a liver cancer cell line.Methods: First, we employed a quantitative proteomics approach based on stable isotope labeling by amino acids in cell culture(SILAC) to identify the different proteins expressed in HepG2 liver cancer cells upon exposure to ABA. Next, bioinformatics analyses through DAVID and STRING on-line tools were used to predict the pathways involved. Finally, we applied functional validation including cell cycle analysis and Western blotting for apoptosis and mTOR pathway-related proteins to confirm the bioinformatics predictions.Results: We identified 330 different proteins with the SILAC-based quantitative proteomics approach. The bioinformatics analysis and the functional validation revealed that the mTOR pathway, ribosome biogenesis, cell cycle, and apoptosis pathways were differentially regulated by ABA. G1 cell cycle arrest, apoptosis and mTOR inhibition were confirmed.Conclusions: ABA, a potential mTOR inhibitor, induces the disruption of ribosomal biogenesis. It also affects the mTOR-MRP axis to cause G1 cell cycle arrest and finally leads to cancer cell apoptosis. | Ji Xia Qiang Luo Shengbin Huang Fuquan Jiang Lin Wang Guanghui Wang Jingjing Xie Jie Liu Yang Xu | 2019 | Chinese Journal of Cancer Research2019，31，2： | 2 |
| 2 | Variational inclutions with a generalized H-monotone operator in Banach spaces显示文摘 | Xia Fuquan Huang Nanjing | 2007 | Comput Math App12007，54，1： | 1 |
| 3 | Forward and symmetric Wick-Itôintegrals with respect to fractional Brownian motion显示文摘Let BH={BHt,t≥0}be a fractional Brownian motion with Hurst index H∈(0,1).Inspired by pathwise integrals and Wick product,in this paper,we consider the forward and symmetric Wick-Itôintegrals with respect to BH as follows:∫t0us⋄d−BHs=limε↓01ε∫t0us⋄(BHs+ε−BHs)ds,∫t0us⋄d∘BHs=limε↓012ε∫t0us⋄(BHs+ε−BH(s−ε)∨0)ds,in probability,where◊denotes the Wick product.We show that the two integrals coincide with divergence-type integral of BH for all H∈(0,1). | Fuquan XIA Litan YAN Jianhui ZHU | 2021 | Frontiers of Mathematics in China2021，16，2： | 0 |
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