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| 1 | Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma显示文摘Type 2 inflammation is a complex immune response and primary mechanism for several common allergic diseases including allergic rhinitis,allergic asthma,atopic dermatitis,and chronic rhinosinusitis with nasal polyps.It is the predominant type of immune response against helminths to prevent their tissue infiltration and induce their expulsion.Recent studies suggest that epithelial barrier dysfunction contributes to the development of type 2 inflammation in asthma,which may partly explain the increasing prevalence of asthma in China and around the globe.The epithelial barrier hypothesis has recently been proposed and has received great interest from the scientific community.The development of leaky epithelial barriers leads to microbial dysbiosis and the translocation of bacteria to inter-and sub-epithelial areas and the development of epithelial tissue inflammation.Accordingly,preventing the impairment and promoting the restoration of a deteriorated airway epithelial barrier represents a promising strategy for the treatment of asthma.This review introduces the interaction between type 2 inflammation and the airway epithelial barrier in asthma,the structure and molecular composition of the airway epithelial barrier,and the assessment of epithelial barrier integrity.The role of airway epithelial barrier disruption in the pathogenesis of asthma will be discussed.In addition,the possible mechanisms underlying the airway epithelial barrier dysfunction induced by allergens and environmental pollutants,and current treatments to restore the airway epithelial barrier are reviewed. | Xiang Dong Mei Ding Jinjin Zhang Ismail Ogülür Yagiz Pat Mübeccel Akdis Yadong Gao Cezmi A.Akdis | 2022 | Chinese Medical Journal2022，，5： | 4 |
| 2 | SKP2/P27 expression Profile is correlated with epstein-Barr virus status in extranodal nasal-type natural Killer cell lymphoma显示文摘 | Xiang L M Zu L S Dan H | 2008 | Transl Res2008，151，6： | 1 |
| 3 | Exploring the neutral invertase-oxidative stress defence connection in Ara-bidopsis thaliana显示文摘 | XIANG L LE ROY K BOLOURI-MOGHADDAM M K etal | 2011 | Journal of Experimental Botany2011，6211，： | 1 |
| 4 | Protein-protein interactions: hot spots and structurally conserved residues often located in complemented pockets that pre-organized in the unbound states: implications for docking 显示文摘 | Xiang L Ozlem K Buyong M | 2004 | J Mol Biol2004，344，3： | 1 |
| 5 | Color Fine-Tuning of CNTs@AAO Composite Thin Films via Isotropically Etching Porous AAO Before CNT Growth and Color Modification by Water Infusion显示文摘 | Xiang L Z Guowen M | 2010 | Adv Mater2010，22，： | 1 |
| 6 | Experimental study of debris capture efficiency of trash racks 显示文摘 | Xiang Fu Kavvas L M Chen Zhiqiang | 2009 | Journal of Hydro-Environment Research2009，3，3： | 1 |
| 7 | Phenotypic and functional character- ization of human γδT-Cell subsets in response to in fluenza a viruses显示文摘 | Qin G Liu Y Zheng J Xiang Z Ng I H Peiris J M Lau Y L Tu W | 2012 | J Infect Dis2012，205，11： | 1 |
| 8 | Interferometric estimation of three-dimensional surface deformation using geosynchronous circular SAR显示文摘 | Kou L Wang X Xiang M | 2012 | IEEE Transactions on Aerospace and Electronic Systems2012，48，2： | 1 |
| 9 | Edge-directed Single-image Super-resolution via Adaptive Gradient Magnitude Self-interpolation 显示文摘 | WANG L F XIANG S M MENG G F | 2013 | IEEE Transactions on Circuits and Systems for Video Technology2013，23，8： | 1 |
| 10 | Targeted deletion of the mouse POU domain gone Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling显示文摘 | XIANG M CAN L ZHOU L | 1996 | Pro: Nail Acad Sci USA1996，93，11： | 1 |
| 11 | Study on refining process of red clover total isoflavone显示文摘 | LI C M XIANG Y ZHAI L | 2004 | Chin Tradit Herb Drugs2004，35，： | 1 |
| 12 | On constructing a binary tree from its traversals 显示文摘 | Xiang L M Lawi A Ushijima K | 2000 | Research Reports on Information Science and Electrical Engineering of Kyushu University2000，5，1： | 1 |
| 13 | Characterization of stress-responsive CIPK genes in rice for stress toler- ance improvement 显示文摘 | XIANG Y HUANG Y M XIONG L Z | 2007 | Plant ''Physiology2007，144，3： | 1 |
| 14 | Influence of Sn on mi- crostructure and mechanical properties of Mg-5Li-3A1- 2Zn alloys 显示文摘 | Xiang Q Wu R Z Zhang M L | 2009 | Journal of Alloys and Compounds2009，477，： | 1 |
| 15 | The clinical characteristics and prognostic significance of MN1 gene and MN1-associated microRNA expression in adult patients with de novo acute myeloid leukemia显示文摘 | Xiang L Li M Liu Y | 2013 | Ann Hematol2013，92，8： | 1 |
| 16 | Strategies for antiplatelet targets and agents显示文摘 | XIANG Y Z KANG L Y GAO X M | 2008 | Thromb Res2008，123，： | 1 |
| 17 | Advances in Research on Circulating Tumor Cell显示文摘 | Zhu L Xiang M Liu X | 2014 | Xian DaiZhong Liu Xue2014，22，11： | 1 |
| 18 | Long-chain polyunsaturated fatty acids in Chinese and Swedish mothers:diet,breast milk and infant growth显示文摘 | Xiang M Harbige L S Zetterstrom R | 2005 | Acta Paediatr2005，94，11： | 1 |
| 19 | Cancer stem ceils: a contentious hypothesis now moving forward 显示文摘 | O'Connor M L Xiang D Shigdar S | 2014 | Cancer Lett2014，344，2： | 1 |
| 20 | Central pancreatectomy for benign or borderline lesions of the pancreatic neck: a single centre experience and literature review显示文摘 | Xiang G M Tan C L Zhang H Ran X Mai G Liu X B | 2012 | Hepatogastroenterology2012，59，： | 1 |
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