3篇
您的检索式：作者名="Xiang Yixian"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Specific Regulation of m^(6)A by SRSF7 Promotes the Progression of Glioblastoma显示文摘Serine/arginine-rich splicing factor 7(SRSF7),a known splicing factor,has been revealed to play oncogenic roles in multiple cancers.However,the mechanisms underlying its oncogenic roles have not been well addressed.Here,based on N6-methyladenosine(m^(6)A)co-methylation network analysis across diverse cell lines,we find that the gene expression of SRSF7 is positively correlated with glioblastoma(GBM)cell-specific m^(6)A methylation.We then indicate that SRSF7 is a novel m^(6)A regulator,which specifically facilitates the m^(6)A methylation near its binding sites on the mRNAs involved in cell proliferation and migration,through recruiting the methyltransferase complex.Moreover,SRSF7 promotes the proliferation and migration of GBM cells largely dependent on the presence of the m^(6)A methyltransferase.The two m^(6)A sites on the mRNA for PDZ-binding kinase(PBK)are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2).Together,our discovery reveals a novel role of SRSF7 in regulating m^(6)A and validates the presence and functional importance of temporal-and spatial-specific regulation of m^(6)A mediated by RNA-binding proteins(RBPs). | Yixian Cun Sanqi An Haiqing Zheng Jing Lan Wenfang Chen Wanjun Luo Chengguo Yao Xincheng Li Xiang Huang Xiang Sun Zehong Wu Yameng Hu Ziwen Li Shuxia Zhang Geyan Wu Meisongzhu Yang Miaoling Tang Ruyuan Yu Xinyi Liao Guicheng Gao Wei Zhao Jinkai Wang Jun Li | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 2 | Fe-doped SnO_(2) nanosheet for ambient electrocatalytic nitrogen reduction reaction显示文摘Ammonia plays a vital role in the development of modern agriculture and industry.Compared to the conventional Haber–Bosch ammonia synthesis in industry,electrocatalytic nitrogen reduction reaction(NRR)is considered as a promising and environmental friendly strategy to synthesize ammonia.Here,inspired by biological nitrogenase,we designed iron doped tin oxide(Fe-doped SnO_(2))for nitrogen reduction.In this work,iron can optimize the interface electron transfer and improve the poor conductivity of the pure SnO_(2),meanwhile,the synergistic effect between iron and Sn ions improves the catalyst activity.In the electrocatalytic NRR test,Fe-doped SnO_(2) exhibits a NH_(3) yield of 28.45μg·h^(−1)·mgcat^(−1),which is 2.1 times that of pure SnO_(2),and Faradaic efficiency of 6.54%at−0.8 V vs.RHE in 0.1 M Na_(2)SO_(4).It also shows good stability during a 12-h long-term stability test.Density functional theory calculations show that doped Fe atoms in SnO_(2) enhance catalysis performance of some Sn sites by strengthening N–Sn interaction and lowering the energy barrier of the rate-limiting step of NRR.The transient photovoltage test reveals that electrons in the low-frequency region are the key to determining the electron transfer ability of Fe-doped SnO_(2). | Yaxi Li Yixian Liu Xiang Liu Yunliang Liu Yuanyuan Cheng Peng Zhang Peiji Deng Jiujun Deng Zhenhui Kang Haitao Li | 2022 | Nano Research2022，15，7： | 0 |
| 3 | A Modest Study on Ba Culture and Architecture显示文摘Ba people are inherently different from Shu people,but they are also complementary to each other.Ba people are represented to have rough masculine qualities,while Shu people are distinctly described as gentle and graceful,entirely different from the vigorous Ba.The initial buildings of the Ba people were rock pits slightly reorganized in virtue of convenient geographical conditions,which are regarded as the earliest life pattern of the Ba people.After long study and progress,Ba people ultimately came out of wild pits,and perfected the dry column buildings by creating stilted buildings,which bring both security and superiority.The Ba people found the subtlest equilibrium point between utility and aesthetics,achieving a true harmony between human beings and nature. | Xiang Yixian Ding Xiaohua | 2017 | Contemporary Social Sciences2017，2，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员