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| 1 | Therapeutic potential of siRNA-mediated combined knockdown of the lAP genes (Livin, XIAP, and Survivin) on human bladder cancer T24 cells显示文摘Livin, apoptosis (XIAP ) 的 X 连接禁止者,和 Survivin 几乎是 apoptosis 的三个著名禁止者在癌症房间只过去表示并且为癌症治疗被认为有势力目标。在现在的学习,我们发现 Livin, XIAP,和 Survivin 同时在膀胱癌症房间被表示。我们推测了那 Livin, XIAP,和 Survivin 可能在房间生长和 apoptosis 上有 synergistic 效果。我们的结果证实了联合那所有这三基因击倒能 synergistically 禁止增长和高级膀胱癌症 T24 房间的转变能力并且把房间 apoptotic 敏感提升到化疗。而且,联合了 Livin, XIAP,和 Survivin 罐头击倒显著地增加许多活跃 caspase-3,活跃 caspase-7,活跃 caspase-9,和 cytosolic Smac。我们的调查结果暗示 Livin, XIAP,和 Survivin 的那联合 silencing 可以是一个有势力为膀胱癌症的多指向的基因治疗。 | Deyong Yang Xishuang Song Jianing Zhang Lin Ye Shujing Wang Xiangyu Che Jianbo Wang Zhiwei Zhang Lina Wang Wei Shi | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 29 |
| 2 | Zinc sensitizes prostate cancer cells to sorafenib and regulates the expression of Livin显示文摘在前列腺 carcinogenesis,正常积累锌的上皮的房间被转变成不积累锌的恶意的房间。锌的增加的层次被显示了在前列腺癌症房间与下面调整的 anti-apoptotic 蛋白质通过 caspase 依赖的机制导致 apoptosis。我们的以前的学习显示出那,作为 apoptosis 的禁止者的一个成员蛋白质(国际机场) 家庭, Livin 能在人的前列腺癌症的开始起一个重要作用并且由改变 G1S 房间周期转变支持房间增长。在现在的学习,我们测量了前列腺癌症房间的 apoptosis 敏感到锌和 sorafenib 并且发现那锌敏化前列腺癌症房间到导致 sorafenib 的 apoptosis。令人惊讶地,我们也发现 Livin 不同于它的对应物 Survivin 和 cIAP2,没总是被减少;相反,它赔偿地在前列腺癌症房间在 48 h 在调停锌的 apoptosis 被增加。我们可以扩充 sorafenib 的效果,并且也第一次揭示的结果提议潜力治疗联合,那增加的 Livin 表情可以在对锌的前列腺癌症房间的早房间死亡反应起一个作用。 | Xiaochi Chen Xiangyu Che Jianbo Wang Feng Chen Xuejian Wang Zhiwei Zhang Bo Fan Deyong Yang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 5 |
| 3 | One-Dimensional Magnetic FeCoNi Alloy Toward Low-Frequency Electromagnetic Wave Absorption显示文摘Rational designing of one-dimensional(1D)magnetic alloy to facilitate electromagnetic(EM)wave attenuation capability in low-frequency(2-6 GHz)microwave absorption field is highly desired but remains a significant challenge.In this study,a composite EM wave absorber made of a FeCoNi medium-entropy alloy embedded in a 1D carbon matrix framework is rationally designed through an improved electrospinning method.The 1D-shaped FeCoNi alloy embedded composite demonstrates the high-density and continuous magnetic network using off-axis electronic holography technique,indicating the excellent magnetic loss ability under an external EM field.Then,the in-depth analysis shows that many factors,including 1D anisotropy and intrinsic physical features of the magnetic medium-entropy alloy,primarily contribute to the enhanced EM wave absorption performance.Therefore,the fabricated EM wave absorber shows an increasing effective absorption band of 1.3 GHz in the low-frequency electromagnetic field at an ultrathin thickness of 2 mm.Thus,this study opens up a new method for the design and preparation of high-performance 1D magnetic EM absorbers. | Bintong Yang Jiefeng Fang Chunyang Xu Hui Cao Ruixuan Zhang Biao Zhao Mengqiu Huang Xiangyu Wang Hualiang Lv Renchao Che | 2022 | Nano-Micro Letters2022，14，10： | 4 |
| 4 | Comparing the Safety and Efficiency of Conventional Monopolar, Plasmakinetic, and Holmium Laser Transurethral Resection of Primary Non - muscle Invasive Bladder Cancer 显示文摘 | Song Xishuang Yang Deyong Che Xiangyu | 2010 | Journal of Endourology2010，24，1： | 1 |
| 5 | Spatial and temporal assessment of the initial pattern of phytoplankton population in a newly built coastal reservoir显示文摘为十年,对一个宗主国的水安全的主要威胁例如上海的城市,是对水的很快成长的要求,包括超营养作用并且同时,在水质量的减少。因此,上海转移了比较喜欢的淡水来源到 Yangtze 河口并且构造了 Qingcaosha 水库,它从长江服从于更少的发育营养正常促进剂水。第一次估计浮游植物的人口在新建水库,这研究改进了一个综合方法在 large-water-area 水库和湖估计浮游植物模式,用部分 triadic 分析和地理信息系统。每月的采样并且从 2010 年 7 月在水库从 10 个车站监视到 2011 年 12 月被进行。学习检验了浮游植物人口结构的普通模式并且在水库的转变时期期间在浮游植物社区的特定的作文决定了差别。结果建议那在几乎,三采样在 Qingcaosha 水库的上面的部分驻扎,在 2011 有强壮的普通妥协。二个很重要的时期从迟了的夏天发生了到秋天并且从冬季到早春。前者被 cyanobacteria 的优势描绘,而后者被 chlorophyta 和硅藻的优势描绘。Cyanobacteria (Microcystis spp。作为主要的类) 是在在水库操作以后的夏天的独占性的主导的种。统计分析也为在水库并且在几有限的种上的更低的部分集中于车站的常规监视显示了必要性。 | Xiangyu REN Kai YANG Yue CHE Mingwei WANG Lili ZHOU Liqiao CHEN | 2016 | Frontiers of Earth Science2016，10，3： | 0 |
| 6 | Review and prospect of immune checkpoint blockade therapy represented by PD-1/PD-L1 in the treatment of clear cell renal cell carcinoma显示文摘As a common tumor of the urinary system,the morbidity and mortality related to renal carcinoma,are increasing annually.Clear cell renal cell carcinoma(CCRCC)is the most common subtype of renal cell carcinoma,accounting for approximately 75%of the total number of patients with renal cell carcinoma.Currently,the clinical treatment of ccRCC involves targeted therapy,immunotherapy,and a combination of the two.In immunotherapy,PD-1/PD-L1 blocking of activated T cells to kill cancer cells is the most common treatment.However,as treatment progresses,some patients gradually develop resistance to immunotherapy.Meanwhile,other patients experience great side effects after immunotherapy,resulting in a survival status far lower than the expected survival rate.Based on these clinical problems,many researchers have been working on the improvement of tumor immunotherapy in recent years and have accumulated numerous research results.We hope to find a more suitable direction for future immunotherapy for ccRCC by combining these results and the latest research progress. | WENFEI GE SHIYAN SONG XIAOCHEN QI FENG CHEN XIANGYU CHE YONGHAO SUN JIN WANG XIAOWEI LI NANA LIU QIFEI WANG GUANGZHEN WU | 2023 | Oncology Research2023，31，3： | 0 |
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