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| 1 | Apoptotic mechanism of MCF-7 breast cells in vivo and in vitro induced by photodynamic therapy with C-phycocyanin显示文摘这研究的目的是调查 C-phycocyanin (CPC ) 的 pro-apoptotic 机制在一个鼠科的肿瘤模型和有教养的 MCF-7 房间的调停的光力学的治疗(太平洋夏季时间) 。老鼠被划分成四个组:控制, HeNe 激光放射, CPC 处理,和 CPC 处理 + HeNe 激光放射。有免疫力的机关, immunocyte 增长,肿瘤开始,和 apoptosis 相关的蛋白质表情上的 CPC 或激光的效果被 immunohistochemistry 调查,在 situ 杂交, MTT,电子显微镜,西方的污点,和 immunofluorescence 试金。结果证明 HeNe 激光处理独自显示出边缘的效果。在 C-PC-treated 老鼠,有免疫力的机关的重量, immunocytes 的增长,和 pro-apoptotic 的表示,船边交货蛋白质被增加,而肿瘤重量和 anti-apoptotic 蛋白质(NF-B 和 P53 ) 和 CD44 mRNA 的表情比较地被减少。在 vitro, CPC 能包括 microvilli 损失,膜水泡的形成,和染色质冷凝作用禁止 MCF-7 房间增长和原因 ultrastructural 变化。而且, CPC 处理能激活 caspase-9 表示,导致细胞色素 c 版本,和 downregulate Bcl-2 表示。当与 HeNe 激光照耀结合了时, CPC 处理的效果进一步被提高。便于 apoptosis 信号 transduction 并且最后导致 MCF-7 房间的 apoptosis 可以是 C-PC-mediated 太平洋夏季时间的反肿瘤活动的机制。 | Bing Li Xianming Chu Meihua Gao Wuxiu Li | 2010 | Acta Biochimica et Biophysica Sinica2010，42，1： | 22 |
| 2 | Coronary heart disease: incidence, risk factors and interventions in Jiaozhou of Shandong province显示文摘 | Yu Hua Li Dan Chu Xianming An Yi Song Tongxun Feng Huixin Lin Peilin Wang Tao Jiang Shaoyan Guo Linlin Xu Fengqiang Liu Zhengke Yang Bin | 2014 | Chinese Medical Journal2014，，12： | 5 |
| 3 | Environmentally responsive dual-targeting nanotheranostics for overcoming cancer multidrug resistance显示文摘The development of multiple drug resistance(MDR) to chemotherapy and subsequent treatment failures are major obstacles in cancer therapy. An attractive option for combating MDR is inhibiting the expression of P-glycoprotein(P-gp) in tumor cells. Here, we report a novel chemosensitizing agent, XMD8-92,which can down-regulate P-gp. To enhance the specificity of MDR chemotherapy, a promising nanotheranostic micelle system based on poly(ethylene glycol)-blocked-poly(L-leucine)(PEG-b-Leu) was developed to simultaneously carry the anticancer drug doxorubicin, chemosensitizing agent XMD8-92, and superparamagnetic iron oxide nanoparticles(SPIOs). Featured with MDR environmentally responsive dual-targeting capability, controllable drug delivery, and efficient magnetic resonance(MR) imaging characteristics, the prepared nanotheranostics(DXS@NPs) showed outstanding in vitro cytotoxicity on MDR cells(SCG 7901/VCR) with only 53% of cells surviving compared to 90% of DOX-treated cells.Furthermore, efficient tumor inhibition and highly reduced systemic toxicity were exhibited by MDR tumor-bearing mice treated with DXS@NPs. Overall, the environmentally responsive dual-targeting nanotheranostics represent a promising approach for overcoming cancer MDR. | Caixia Yang Xin Pang Weihai Chen Xiaoyong Wang Gan Lin Chengchao Chu Xianzheng Zhang Xianming Deng Xiaoyuan Chen Gang Liu | 2019 | Science Bulletin2019，64，10： | 3 |
| 4 | Pd nanoparticles on defective polymer carbon nitride:Enhanced activity and origin for electrocatalytic hydrodechlorination reaction显示文摘Here we report a facile defect-engineering strategy on the support to optimize the metal-support interaction and enhance the metal’s electrocatalytic hydrodechlo rination perfo rmance in converting 2,4-dichlorophenol(2,4-DCP)to phenol.The specific activity of the Pd nanoparticles(Pd NPs)on defective polymer carbon nitride(Pd/PCN-x)reaches 0.09 min^(-1) m^-2Pd,which is 1.5 times that of the Pd NPs supported on the perfect PCN(Pd/PCN-0).The combined experimental and theoretical results demonstrate that the strong adsorption of phenol on Pd/PCN-0 passivates the active sites,limiting the dechlorination progress.The PCN-x containing-C≡N defects can effectively mediate the spatial configuration and electronic structure of Pd NPs,and promote the preferential adsorption of 2,4-DCP rather than phenol,resulting in an enhanced dechlorination efficiency. | Song Shu Peng Wang Wendong Zhang Weilu Wang Jianjun Li Yinghao Chu Fusheng Wei Xianming Zhang Guangming Jiang | 2020 | Chinese Chemical Letters2020，31，10： | 0 |
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