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| 1 | The chimeric Japanese encephalitis/Dengue 2 virus protects mice from challenge by both dengue virus and JEV virulent virus显示文摘 | Yang, Jian Yang, Huiqiang Li, Zhushi Lin, Hua Zhao, Yu Wang, Wei Tan, Shuai Zeng, Xianwu Li, Yuhua | 2017 | Protein & Cell2017，8，3： | 7 |
| 2 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 3 | Dynamical behavior for a three-dimensional differential equation in chemical system显示文摘 | Yiping Lin Xianwu Zheng and Zujun Jing | 1995 | Acta mathematical applicant science1995，12，2： | 1 |
| 4 | Silencing transformer and transformer-2 in Zeugodacus cucurbitae causes defective sex determination with inviability of most pseudomales显示文摘transformer is a switch gene for sex determination in many insects, which cooperates with transformer-2 that is expressed in both sexes to regulate female differentiation, particularly in dipterans. Zeugodacus cucurbitae(Coquillett) is a very destructive pest worldwide, however, its sex determination pathway remains largely uncharacterized. Here, we show that the female sex ratio is sharply reduced with knockdown of either transformer or transformer-2 by RNA interference in early embryos of Z. cucurbitae. Most of the males grown from the embryos with transient transformer and transformer-2 suppression mated with wild-type females and produced mixed sex progeny, with one exception that produced only female progeny, and all of the few remaining males failed to mate with wild-type females and produced no progeny. The exceptional male and those males with mating failure were XX pseudomales as determined by the detection of Y chromosome-linked Maleness-on-the-Y, indicating that most XX pseudomales are not viable. The phenotypes of transformer and transformer-2 suggest that they play a key role in regulating sex determination and are required for female sexual development of Z. cucurbitae. Our results will be beneficial to the understanding of sex determination in Z. cucurbitae and can facilitate the development of genetic sexing strains for its biological control. | Qin Ma Zizhen Fan Ping Wang Siya Ma Jian Wen Fengqin Cao Xianwu Lin Rihui Yan | 2024 | Journal of Integrative Agriculture2024，23，3： | 0 |
| 5 | Altered gene expression in human brain microvascular endothelial cells in response to the infection of influenza H1N1 virus显示文摘Influenza viruses not only cause respiratory illness,but also have been reported to elicit neurological manifestations following acute viral infection.The central nervous system(CNS)has a specific defense mechanism against pathogens structured by cerebral microvasculature lined with brain endothelial cells to form the blood–brain barrier(BBB).To investigate the response of human brain microvascular endothelial cells(hBMECs)to the Influenza A virus(IAV),we inoculated the cells with the A/WSN/33(H1N1)virus.We then conducted an RNAseq experiment to determine the changes in gene expression levels and the activated disease pathways following infection.The analysis revealed an effective activation of the innate immune defense by inducing the pattern recognition receptors(PRRs).Along with the production of proinflammatory cytokines,we detected an upregulation of interferons and interferon-stimulated genes,such as IFN-β/λ,ISG15,CXCL11,CXCL3 and IL-6,etc.Moreover,infected hBMECs exhibited a disruption in the cytoskeletal structure both on the transcriptomic and cytological levels.The RNAseq analysis showed different pathways and candidate genes associated with the neuroactive ligand-receptor interaction,neuroinflammation,and neurodegenerative diseases,together with a predicted activation of the neuroglia.Likewise,some genes linked with the mitochondrial structure and function displayed a significantly altered expression.En masse,this data supports that hBMECs could be infected by the IAV,which induces the innate and inflammatory immune response.The results suggest that the influenza virus infection could potentially induce a subsequent aggravation of neurological disorders. | Doaa Higazy Xianwu Lin Tanghui Xie Ke Wang Xiaochen Gao Min Cui | 2023 | Animal Diseases2023，3，1： | 0 |
| 6 | An analysis on the airship dynamic model linearization显示文摘The existing results on airship dynamic model linearization are usually achieved under the assumption that the airship trim state has a linear velocity with nonzero axial and normal components. This means that the direction of airship velocity is not coincident with the axis in the trim state and the deflection angles of the air rudders are different from their attack angles. However, these differences are not explicitly distinguished when calculating the air rudders' aerodynamic force. In this paper, to build a more accurate airship dynamic model, aerodynamic forces and moments produced by the air rudders are deduced for the case that the direction of airship velocity is not coincident with the trim axis. A special trim state that all linear and angular velocities are zeros except axial and normal linear velocity, adopted by most research on airship dynamic model linearization, is selected to linearize the six degree airship dynamic model for simplicity and for comparison. Both the control forces of the propelling system and the air rudders are linearized to achieve more control inputs for the linear model. The extra control inputs provided by the propelling system can be used to stabilize the airship when the air rudders are invalid due to low speed of the airship or the constraint of air rudder mechanical strength. The nuance between the new linearized model and those deduced in the literature is discussed. | Xianwu LIN Weiyao LAN | 2013 | 控制理论与应用(英文版)2013，11，3： | 0 |
| 7 | A Continuous Time Domain Direct Identication Method for Unsteady Fluid Dynamic Model in Incompressible Flow显示文摘To identify the unsteady°uid dynamic model for a solid moving in the°uid,a new identication method that operates in the continuous time domain is proposed.It is illustrated that this new identication method is more accurate and appropriate for identifying unsteady°uid dynamic model in incompressible°ow in comparison with the classical frequency domain or discrete domain method.This new method is applied to identify the unsteady°uid dynamic models of a NACA0012 airfoil and the e®ect of the°uid viscosity on the model parameter is analyzed.The result shows that the added mass in viscous°ow is dependent on the input signal frequency and is exactly the added mass in inviscid°ow when the frequency approaches innity.Based on this discovery,the long controversy on the relationship of added mass between viscous and inviscid°ow is solved.Then,the enlightenment of this discovery on the identication of both linear and nonlinear unsteady aerodynamic model in incompressible°ow is illustrated.At last,the advantage of the new acquired unsteady°uid dynamic model is discussed in comparison with the classical quasi-steady aerodynamic model. | Xianwu Lin Tao Li Lixun Xiong Delin Luo | 2023 | Guidance, Navigation and Control2023，3，1： | 0 |
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