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| 1 | Integrated DNA-based/biochemical screening for early diagnosis of multiple endocrine neoplasia type 2A (MEN2A)显示文摘Multiple endocrine neoplasia type 2A (MEN2A), a subtype of MEN2, is characterized by medullary thyroid cancer, pheochromocytoma, and primary hyperparathyroidism. A Han Chinese pedigree with MEN2A was investigated following confirmation of the proband's diagnosis by pathological findings and DNA/biochemical screening. DNA samples from 4 other family members were collected and exon 5, 8, 10, 11, 13, 16 and 18 of the RET proto-oncogene were sequenced and then analyzed. A missense mutation of TGG (Trp) to TGC (Cys) at codon 634 (the classic MEN2A mutation) in exon 11 of the RET gene was detected in 3 family members, including the proband. Sequencing data were compared with the human gene mutation database. Elevated serum calcitonin level was detected initially; medullary thyroid carcinoma was revealed in the 3 cases and adrenal pheochromocy-toma was also found in the proband. Elective operations were successfully performed on the adrenal and thyroid glands because of pheochromocytoma and medullary thyroid carcinoma. Our case study confirms that integrated DNA-based/biochemical screening is crucial for early diagnosis of MEN2A and is helpful in the screening of their relatives. In addition, DNA-based screening may occasionally uncover a previously unknown RET sequence. | Qin Cui Wen Wang Zhenzhen Fu Xin Shao Zhihong Zhang Mei Zhang Xianxia Ju Kunlin Wang Jiawei Chen Hongwen Zhou | 2013 | The Journal of Biomedical Research2013，27，2： | 3 |
| 2 | Cobalt sulfides as efficient catalyst towards oxygen reduction reactions显示文摘Developing low-cost and high performance catalysts to replace precious metal based catalysts for oxygen reduction reaction(ORR) is one of the most feasible ways to promote the commercial application of fuel cells.In this work,flower-like CoS and octahedral CoS_2 are synthesized by a facile one-pot hydrothermal method without any adjunction of surfactants or follow-up thermolysis,their catalytic performance towards ORR in alkaline electrolyte are comparatively investigated.The results reveal that CoS_2 outperforms CoS owing to the higher electron density around S-S bond of S_2^(2-) in the crystal structure,which promotes the adsorption of oxygen on catalyst surface and facilitates the breakage of O-O bond in oxygen,leading to direct 4-electron transfer ORR.When CoS_2 particles are dispersed on the surface of rGO with large surface area,their ORR performance could be further improved. | Shuo Yao Taizhong Huang Hengyi Fang Jiemei Yu Mayilvel Dinesh Meganathan Zhaoxin Cui Xianxia Yuan | 2020 | Chinese Chemical Letters2020，31，2： | 3 |
| 3 | Electrochemical performance of a novel CoTETA/C catalyst for the oxygen reduction reaction显示文摘 | Hui-Juan Zhang Xianxia Yuan Wen Wen Dong-Yun Zhang Liangliang Sun Qi-Zhong Jiang Zi-Feng Ma | 2008 | Electrochemistry Communications2008，，1： | 1 |
| 4 | A probe into 'mining technique in the condition of floor failure' for coal seam above longwall goals 显示文摘 | FENG Guorui WANG Xianxia KANG Lixun | 2008 | Journal of Coal Science &Engineering2008，14，1： | 1 |
| 5 | Pyrolyzed CoN4-chelate as an electrocatalyst for oxygen reduction reaction in acidmedia显示文摘 | Zhang Huijuan Yuan Xianxia Ma Zifeng | 2010 | lnternationalJournalofHydrogenEnergy2010，35，： | 1 |
| 6 | A three-dimensional fuzzy control methodology for a class of distributed parameter systems显示文摘 | LI Hanxiong ZHANG Xianxia LI Shaoyuan | 2007 | IEEE Transaction on Fuzzy Systems2007，15，3： | 1 |
| 7 | Electro-chemical performance of a novel CoTETA/C catalyst forthe oxygen reduction reaction显示文摘 | Zhang Hui-juan Yuan Xianxia Wen Wen | 2009 | ElectrochemistryCommunications2009，11，1： | 1 |
| 8 | Charac- teristics of LaNi5-based hydrogen storage alloys modified by partial substituting La for Ce显示文摘 | YUAN Xianxia LIU Hansan MA Zifeng | 2003 | Journal of Alloys and Compounds2003，359，： | 1 |
| 9 | A steganographic method based upon JPEG and particle swarm optimization algorithm显示文摘 | LI Xianxia WANG Jianjun | 2007 | Information Sciences2007，177，： | 1 |
| 10 | Determination of hydrogen diffusion coefficient in metal hydride electrode by modified Warburg impedance显示文摘 | Yuan Xianxia Xu Naixin | | 0，，： | 1 |
| 11 | Characteristics of LaNis-based hydrogen storage alloys modified by partial substituting La for Ce显示文摘 | YUAN Xianxia LIU Hansan MA Zifeng | 2003 | Journal of Alloys and Compounds2003，359，12： | 1 |
| 12 | Pyrolyzed CoN4-chelate as an electrocatalyst for oxygen reduction reaction in acid media 显示文摘 | Zhang Huijuan Yuan Xianxia Sun Liangliang | 2010 | International Journal of Hydrogen Energy2010，35，7： | 1 |
| 13 | A probe into 'mining technique in the condition of floor failure' for coal seam above longwall goafs 显示文摘 | Feng Guorui Wang Xianxia Kang Lixun | 2008 | Journal of Coal Science & Engineering2008，14，1： | 1 |
| 14 | Int J Hydrogen Energy显示文摘 | Ding Xinlong Yuan Xianxia Jia Chao | 2010 | 35:110772010，35，11： | 1 |
| 15 | The Glass-Transition, Crystallization and Melting Characteristics of a Class of Polyester Ionomers 显示文摘 | Guo Xianying Gu Lixia Feng Xianxia | 2002 | J Appl Polym Sci2002，86，： | 1 |
| 16 | ELECTRON MICROANALYSIS FOR LASER MELTED ZONE IN 45 STEEL WITH Fe-Ni-Cr COATING显示文摘The Fe-Ni-Cr coating laver has been alloyed with 45 steel base metal by transverse.flow typeCO2 gas laser of maximum output 5kW.The characteristics of the melted zone and the es-sence of the“bright band”has been investigated using the electron microscopy.The resultsshow that the“bright band”belongs to the melted zone and is a vertical section of the planecrystal,The width of the“bright band”equals the height of the plane crystal,which decreaseswith the increase of laser beam scanning rate and the decrease of laser power.This has beenexplained in terms of constitutional supercooling G/R. | CHENG Yongxing LI Genfu YU Shaoluo Shanghai University of Engineering Science,Shanghai,China WANG Huimin No.11 Institute of China State Shipbuilding Corp.,Shanghai,China Associate Professor,Dept.No.5,Shanghai University of Engineering Science,350 Xianxia Road,Shanghai,China | 1989 | Acta Metallurgica Sinica(English Letters)1989，2，3： | 0 |
| 17 | Scenario-oriented hybrid particle swarm optimization algorithm for robust economic dispatch of power system with wind power显示文摘An economic dispatch problem for power system with wind power is discussed.Using discrete scenario to describe uncertain wind powers,a threshold is given to identify bad scenario set.The bad-scenario-set robust economic dispatch model is established to minimize the total penalties on bad scenarios.A specialized hybrid particle swarm optimization(PSO)algorithm is developed through hybridizing simulated annealing(SA)operators.The SA operators are performed according to a scenario-oriented adaptive search rule in a neighborhood which is constructed based on the unit commitment constraints.Finally,an experiment is conducted.The computational results show that the developed algorithm outperforms the existing algorithms. | WANG Bing ZHANG Pengfei HE Yufeng WANG Xiaozhi ZHANG Xianxia | 2022 | Journal of Systems Engineering and Electronics2022，33，5： | 0 |
| 18 | (Ⅰ+Ⅱ)MIXED MODE HYDROGEN INDUCED CRACKING显示文摘Hydrogen induced cracking(HIC)of 0.3% C,1% Cr,1% Mn,1% Si high strength steel hasbeen studied under simple mode Ⅰ,mode Ⅱ and(Ⅰ+Ⅱ)mixed mode loading conditions.Af-ter being hydrogen-charged in IN H2SO4 solution,the material behaved hydrogenembrittlement in all the cases studied.The threshold KⅡH/KⅡX of HIC under mode Ⅱ load-ing was 0.27,which was nearly the same as that K(ⅠH)/KⅠX=0.29 under mode Ⅰ loading.While the thresholds of-HIC under(Ⅰ+Ⅱ)mixed mode loading were 0.36,0.41 and 0.37 cor-responding to the KⅡ/KⅠ ratio of 0.27,0.4 and O.81.The results show that simple mode Ⅰor mode Ⅱ loading is more susceptible to hydrogen embrittlement than(Ⅰ+Ⅱ)mixed mode.For explaining the experimental results,the effects of triaxial stress as well as plasticdeformation ahead of crack tip has been discussed. | GAO Hua XUE Lijue Shanghai University of Engineering Science,Shanghai,China Associate Professor,Dept.of Materials,Shanghai University of Engineering Science,350 Xianxia Road,Shanghai,China | 1989 | Acta Metallurgica Sinica(English Letters)1989，2，4： | 0 |
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