|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 2 | A small molecular electron acceptor based on asymmetric hexacyclic core of thieno[1,2-b]indaceno[5,6-b']thienothiophene for efficient fullerene-free polymer solar cells显示文摘A novel A-D-A(acceptor-donor-acceptor)type non-fullerene small molecule,A201,consisting of an asymmetric thieno[1,2-b]indaceno[5,6-b^0]thienothiophene(TITT)unit as middle D part and 2-(3-oxo-2,3-dihydroinden-1-ylidene)malononitrile(IC)groups as end-capped A parts was designed and synthesized.The asymmetric TITT building block showed a higher dipole moment of 0.85 Debye(1 Debye=3.33564?10^(à30)cm)compared with the symmetric analogues of indacenodithiophene(IDT)and indacenodithieno[3,2-b]thiophene(IDTT)of 0.098 and 0.13 Debye,respectively.The solution-processed bulk heterojunction solar cells using a benzotriazole(BTA)-based polymer of J71 as donor and A201 as acceptor,showed a power conversion efficiency(PCE)of 9.36%with an open-circuit voltage(V_(oc))of0.88 V,a short-circuit current(J_(sc))of 13.15 m A cm^(à2),and a fill factor(FF)of 0.67,under the illumination of AM 1.5G at 100 m W cm^(à2).The high PCE of this material combination could be attributed to its broad absorption spectrum and the high hole mobility(l_h)and electron mobility(l_e)of 9.56?10^(à4)and 5.17?10^(à4)cm^2V^(à1)s^(à1),respectively.These results indicate that the asymmetric electron-donating segments are promising to construct A-D-A type small molecular acceptors,which could largely enhance the diversity of building blocks to design photovoltaic materials. | Wenchao Zhai Ailing Tang Bo Xiao Xiaochen Wang Fan Chen Erjun Zhou | 2018 | Science Bulletin2018，63，13： | 1 |
| 3 | Constitutive expression of a chrysanthemum phospholipase Dα gene in Chrysanthemum morifolium enhances drought tolerance显示文摘Drought causes water shortage and consequent retardation of plants growth and development.Therefore,improving the drought tolerance of plants is necessary for expanding cultivation and resource promotion.Increasing evidence indicates that phospholipase is involved in the response of plants to drought stress.The objective of this study was to create new drought-tolerant chrysanthemum germplasm,which lays a foundation for the study of the molecular mechanism of phospholipase mediated stress response in chrysanthemum.CmPLDαhas the closest relationship with sunflower HaPLDα,and belongs to the PLDαfamily.CmPLDαover-expressing plants showed a slight shrinking under 20%PEG6000 treatment.The survival rate increased significantly by 1.7−1.8 times that of the wild type.Relative water content(RWC)of CmPLDαover-expressing plants were nearly 10%higher than that of the wild type.Relative electrical conductivity and MDA content were significantly lower than those of the wild type.ABA content of the over-expression lines Z1,Z2 were 1.3 and 1.22 times that of wild type,but ABA content of antisense lines F1,F2 was approximately 0.83 and 0.81 of those of wild type.Most plants of antisense transgenic lines F1,F2 were wrinkled,with a wilting index of 5 and 6,and the survival rate was also lower than that of the wild type after recovery growth.RWC of antisense lines were lower than over-expression lines,relative electrical conductivity and MDA content were significantly higher than those of the wild type.In summary,CmPLDαcould enhance tolerance of chrysanthemum to drought conditions. | Lisheng Zhai Xiaochen Zhu Shujin Yang Chunsun Gu Peng Liu Aiping Song Jiafu Jiang Zhiyong Guan Weimin Fang Fadi Chen Sumei Chen | 2021 | Ornamental Plant Research2021，1，1： | 1 |
| 4 | 江苏省多功能灯杆建设情况显示文摘在江苏省8个城市中,共计18个项目。其中落地项目最多的前三名为无锡市、南通市、常州市。值得注意的是,江苏省已经正式出台多功能灯杆标准。江苏省的多功能灯杆的建设和落地项目一直走在前面! | Xiaochen zhai | 2021 | 城市照明2021，25，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员