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| 1 | microRNA-mediated R gene regulation: molecular scabbards for double-edged swords显示文摘Plant resistance(R) proteins are immune receptors that recognize pathogen effectors and trigger rapid defense responses, namely effector-triggered immunity. R protein-mediated pathogen resistance is usually race specific. During plant-pathogen coevolution,plant genomes accumulated large numbers of R genes. Even though plant R genes provide important natural resources for breeding disease-resistant crops, their presence in the plant genome comes at a cost. Misregulation of R genes leads to developmental defects, such as stunted growth and reduced fertility. In the past decade, many microRNAs(miRNAs) have been identified to target various R genes in plant genomes. miRNAs reduce R gene levels under normal conditions and allow induction of R gene expression under various stresses. For these reasons, we consider R genes to be double-edged 'swords' and miRNAs as molecular 'scabbards'. In the present review, we summarize the contributions and potential problems of these 'swords' and discuss the features and production of the 'scabbards', as well as the mechanisms used to pull the 'sword' from the 'scabbard'when needed. | Yingtian Deng Minglei Liu Xiaofei Li Feng Li | 2018 | Science China(Life Sciences)2018，61，2： | 9 |
| 2 | The development of blood-retinal barrier during the interaction of astrocytes with vascular wall cells显示文摘Astrocytes are intimately involved in the formation and development of retinal vessels.Astrocyte dysfunction is a major cause of blood-retinal barrier injury and other retinal vascular diseases.In this study,the development of the retinal vascular system and the formation of the blood-retinal barrier in mice were investigated using immunofluorescence staining,gelatin-ink perfusion,and transmission electron microscopy.The results showed that the retinal vascular system of mice develops from the optic disc after birth,and radiates out gradually to cover the entire retina,taking the papilla optica as the center.First,the superficial vasculature is formed on the inner retinal layer; then,the vasculature extends into the inner and outer edges of the retinal inner nuclear layer,forming the deep vasculature that is parallel to the superficial vasculature.The blood-retinal barrier is mainly composed of endothelium,basal lamina and the end-feet of astrocytes,which become mature during mouse development.Initially,the naive endothelial cells were immature with few organelles and many microvilli.The basal lamina was uniform in thickness,and the glial end-feet surrounded the outer basal lamina incompletely.In the end,the blood-retinal barrier matures with smooth endothelia connected through tight junctions,relatively thin and even basal lamina,and relatively thin glial cell end-feet.These findings indicate that the development of the vasculature in the retina follows the rules of 'center to periphery' and 'superficial layer to deep layers'.Its development and maturation are spatially and temporally consistent with the functional performance of retinal neurons and photosensitivity.The blood-retinal barrier gradually becomes mature via the process of interactions between astrocytes and blood vessel cells. | Huanling Yao Tianshi Wang Jiexin Deng Ding Liu Xiaofei Li Jinbo Deng | 2014 | Neural Regeneration Research2014，9，10： | 6 |
| 3 | Catalytic conversion of lignocellulosic biomass into chemicals and fuels显示文摘In the search of alternative resources to make commodity chemicals and transportation fuels for a low carbon future,lignocellulosic biomass with over 180-billion-ton annual production rate has been identified as a promising feedstock.This review focuses on the state-of-the-art catalytic transformation of lignocellulosic biomass into value-added chemicals and fuels.Following a brief introduction on the structure,major resources and pretreatment methods of lignocellulosic biomass,the catalytic conversion of three main components,i.e.,cellulose,hemicellulose and lignin,into various compounds are comprehensively discussed.Either in separate steps or in one-pot,cellulose and hemicellulose are hydrolyzed into sugars and upgraded into oxygen-containing chemicals such as 5-HMF,furfural,polyols,and organic acids,or even nitrogen-containing chemicals such as amino acids.On the other hand,lignin is first depolymerized into phenols,catechols,guaiacols,aldehydes and ketones,and then further transformed into hydrocarbon fuels,bioplastic precursors and bioactive compounds.The review then introduces the transformations of whole biomass via catalytic gasification,catalytic pyrolysis,as well as emerging strategies.Finally,opportunities,challenges and prospective of woody biomass valorization are highlighted. | Weiping Deng Yunchao Feng Jie Fu Haiwei Guo Yong Guo Buxing Han Zhicheng Jiang Lingzhao Kong Changzhi Li Haichao Liu Phuc T.T.Nguyen Puning Ren Feng Wang Shuai Wang Yanqin Wang Ye Wang Sie Shing Wong Kai Yan Ning Yan Xiaofei Yang Yuanbao Zhang Zhanrong Zhang Xianhai Zeng Hui Zhou | 2023 | Green Energy & Environment2023，8，1： | 6 |
| 4 | Knockdown of long non-coding RNA LCPAT1 inhibits autophagy in lung cancer显示文摘Objective: Long non-coding RNAs(lnc RNAs) are involved in numerous biological processes in lung cancer cells. In our previous studies, we identified a lnc RNA, ENST00000439577, which is highly expressed in lung carcinomas, and termed it lung cancer progression-associated transcript 1(LCPAT1). To characterize the role of LCPAT1 in lung cancer, we conducted the current study.Methods: Expression of LCPAT1 and autophagy-associated markers in tumor tissues and lung cancer cell lines was determined by real-time quantitative polymerase chain reaction(q PCR). Hematoxylin and eosin(HE) staining, q PCR, Western blot, and immunohistochemistry were performed to evaluate xenografted tumor tissues. Autophagy induced by rapamycin was detected by Western blot and immunofluorescence in lung cancer cell lines.Results: Expression of LCPAT1 and microtubule-associated protein 1 light chain 3 beta(LC3B) was positively correlated in lung cancer. Knockdown of LCPAT1 inhibited tumor growth and suppressed cell autophagy in vivo. Moreover, LCPAT1 knockdown in lung cancer cell lines resulted in decreased autophagy-associated gene expression and alleviated the cell autophagy induced by rapamycin.Conclusions: We speculate that LCPAT1 plays a crucial role in regulating autophagy in lung cancer. | Xiao Yu Xiaofei Ye Hongyan Lin Nannan Feng Sumeng Gao Xiaohong Zhang Yu Wang Herbert Yu Xiaobei Deng Biyun Qian | 2018 | Cancer Biology & Medicine2018，15，3： | 5 |
| 5 | Maize orthologs of rice GS5 and their transregulator are associated with kernel development显示文摘Genome information from model species such as rice can assist in the cloning of genes in a complex genome,such as maize.Here,we identified a maize ortholog of rice GS5 that contributes to kernel development in maize.The genomewide association analysis of the expression levels of ZmGS5,and 15 of its 26 paralogs,identified a trans-regulator on chromosome 7,which was a BAKi-like gene.This gene that we named as ZmBAK1-7 could regulate the expression of ZmGS5 and three of the paralogs.Candidate-gene association analyses revealed that these five genes were associated with maize kernel development-related traits.Linkage analyses also detected that ZmGSs and ZmBAK1-7 co-localized with mapped QTLs.A transgenic analysis of ZmGS5 in Arabidopsis thaliana L.showed a significant increase in seed weight and cell number,suggesting that ZmGS5 may have a conserved function among different plant species that affects seed development. | Jie Liu Min Deng Huan Guo Sharif Raihan Jingyun Luo Yuancheng Xu Xiaofei Dong Jianbing Yan | 2015 | Journal of Integrative Plant Biology2015，57，11： | 4 |
| 6 | Synthesis,gas adsorption and reliable pore size estimation of zeolitic imidazolate framework-7 using CO_2 and water adsorption显示文摘Reliable estimation of the pore size distribution(PSD) in porous materials such as metal–organic frameworks(MOFs) and zeolitic imidazolate frameworks(ZIFs) is crucial for accurately assessing adsorption capacity and corresponding selectivity. In this study, the so-called zeolitic imidazolate framework-7(ZIF-7) is successfully synthesized via relatively fast and convenient microwave technique. The morphology and structure of the obtained MOF were characterized by XRD, SEM and N_2 and CO_2adsorption/desorption isotherms at 77 K and0 °C respectively. Then, to determine the PSD of the fabricated MOF, carbon dioxide isotherms are experimentally measured at various temperatures up to atmospheric pressure. Afterward, the experimental CO_2 isotherms data are utilized in two recently proposed in-house algorithms of SHN1 and SHN2 to extract the true PSD of manufactured ZIF-7. The obtained results revealed that median pore diameter of the fabricated ZIF-7 is estimated around 0.404 nm and 0.370 nm by using CO_2 isotherms at 273 K and 298 K respectively. These values are in good agreement with the real pore diameter of 0.42 nm. Moreover, experimental data of water adsorption isotherms over four different MOFs, borrowed from literature, are employed to illustrate further effectiveness of the above algorithms on successful determination of the corresponding pore size distributions. All predicted PSDs are proved to be in good agreement with those obtained from independent methods such as topology and morphology studies. | Mahdi Niknam Shahrak Morteza Niknam Shahrak Akbar Shahsavand Nasser Khazeni Xiaofei Wu Shuguang Deng | 2017 | Chinese Journal of Chemical Engineering2017，25，5： | 3 |
| 7 | Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression显示文摘 | Xiaofei Wang Haiping Tang Yuling Chen Binghuan Chi Shiyu Wang Yang Lv Di WU Renshan Ge Haiteng Deng | 2016 | Protein & Cell2016，7，4： | 3 |
| 8 | H7N9 virus infection triggers lethal cytokine storm by activating gasdermin E-mediated pyroptosis of lung alveolar epithelial cells显示文摘The H7N9 influenza virus emerged in China in 2013,causing more than 1560 human infections,39% of which were fatal.A ‘cytokine storm’ in the lungs of H7N9 patients has been linked to a poor prognosis and death;however,the underlying mechanism that triggers the cytokine storm is unknown.Here,we found that efficient replication of the H7N9 virus in mouse lungs activates gasdermin E(GSDME)-mediated pyroptosis in alveolar epithelial cells,and that the released cytosolic contents then trigger a cytokine storm.Knockout of Gsdme switched the manner of death of A549 and human primary alveolar epithelial cells from pyroptosis to apoptosis upon H7N9 virus infection,and Gsdme knockout mice survived H7N9 virus lethal infection.Our findings reveal that GSDME activation is a key and unique mechanism for the pulmonary cytokine storm and lethal outcome of H7N9 virus infection and thus opens a new door for the development of antivirals against the H7N9 virus. | Xiaopeng Wan Jiqing Li Yupeng Wang Xiaofei Yu Xijun He Jianzhong Shi Guohua Deng Xianying Zeng Guobin Tian Yanbing Li Yongping Jiang Yuntao Guan Chengjun Li Feng Shao Hualan Chen | 2022 | National Science Review2022，9，1： | 3 |
| 9 | Architecture of Co-layered double hydroxide nanocages/graphene composite electrode with high electrochemical performance for supercapacitor显示文摘A facile hydrolysis method was applied to fabricate high-performance Co-layered double hydroxide(LDH)nanocages/graphene composites for supercapacitors. The materials exhibit enhanced rate capability than the counterpart electrode free of graphene while maintaining a high specific capacitance. In addition,such Co-LDH nanocages/graphene composites display an excellent cycling stability; the capacitance retention of Co-LDH nanocages/graphene composite electrode remains 90.4% after 10000 cycles at a current density of 2 A g(-1). The integration of high capacity of double hydroxide and outstanding conductivity of graphene makes the delicately-designed composites promising candidates for electrode materials for supercapacitors. | Xianyu Chu Ting Deng Wei Zhang Dong Wang Xiaofei Liu Cai Zhang Tingting Qin Liyun Zhang Bingsen Zhang Chengmeng Chen Weitao Zheng | 2018 | Journal of Energy Chemistry2018，27，2： | 2 |
| 10 | Response of PM_(2.5)-bound elemental species to emission variations and associated health risk assessment during the COVID-19 pandemic in a coastal megacity显示文摘The coronavirus(COVID-19)pandemic is disrupting the world from many aspects.In this study,the impact of emission variations on PM_(2.5)-bound elemental species and health risks associated to inhalation exposure has been analyzed based on real-time measurements at a remote coastal site in Shanghai during the pandemic.Most trace elemental species decreased significantly and displayed almost no diel peaks during the lockdown.After the lockdown,they rebounded rapidly,of which V and Ni even exceeded the levels before the lockdown,suggesting the recovery of both inland and shipping activities.Five sources were identified based on receptor modeling.Coal combustion accounted for more than 70%of the measured elemental concentrations before and during the lockdown.Shipping emissions,fugitive/mineral dust,and waste incineration all showed elevated contributions after the lockdown.The total non-carcinogenic risk(HQ)for the target elements exceeded the risk threshold for both children and adults with chloride as the predominant species contributing to HQ.Whereas,the total carcinogenic risk(TR)for adults was above the acceptable level and much higher than that for children.Waste incineration was the largest contributor to HQ,while manufacture processing and coal combustion were the main sources of TR.Lockdown control measures were beneficial for lowering the carcinogenic risk while unexpectedly increased the non-carcinogenic risk.From the perspective of health effects,priorities of control measures should be given to waste incineration,manufacture processing,and coal combustion.A balanced way should be reached between both lowering the levels of air pollutants and their health risks. | Guochen Wang Kan Huang Qingyan Fu Jia Chen Juntao Huo Qianbiao Zhao Yusen Duan Yanfen Lin Fan Yang Wenjie Zhang Hao Li Jian Xu Xiaofei Qin Na Zhao Congrui Deng | 2022 | Journal of Environmental Sciences2022，34，12： | 2 |
| 11 | Stable confinement of Fe/Fe_(3)C in Fe,N-codoped carbon nanotube towards robust zinc-air batteries显示文摘Catalytic oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)have garnered great attention as the key character in metal-air batteries.Herein,we developed a superior nonprecious bifunctional oxygen electrocatalyst,fabricated through spatial confinement of Fe/Fe_(3)C nanocrystals in pyridinic N and Fe-Nx rich carbon nanotubes(Fe/Fe_(3)C-N-CNTs).During ORR,the resultant electrocatalyst exhibits positive onset pote ntial of 1.0 V(vs.RHE),large half-wave potentials of 0.88 V(vs.RHE),which is more positive than Pt/C(0.98 V and 0.83 V,respectively).Remarkably,Fe/Fe_(3)C-N-CNTs exhibits outstanding durability and great methanol tolerance,exceeding Pt/C and most reported nonprecious metal-based oxygen reduction electrocatalysts.Moreover,Fe/Fe_(3)C-N-CNTs show a markedly low potential at j=10 mA/cm^(2),small Tafel slopes and extremely high stability for OER.Impressively,the Fe/Fe_(3)C-N-CNTs-based Zn-air batteries demonstrate high power density of 183 mW/cm^(2)and robust charge/discharge stability.It is revealed that the spatial confinement effect can impede the aggregation and corrosion of Fe/Fe_(3)C nanocrystals.Meanwhile,Fe/Fe_(3)C and Fe-Nx play synergistic effect on boosting the ORR/OER activity,which provides an important guideline for construction of inexpensive nonprecious metal-carbon hybrid nanomaterials. | Lingbo Zong Xin Chen Shuming Dou Kaicai Fan Zumin Wang Wenjun Zhang Yunmei Du Jie Xu Xiaofei Jia Qi Zhang Xia Li Yida Deng Yanan Chen Lei Wang | 2021 | Chinese Chemical Letters2021，32，3： | 2 |
| 12 | Rice In Vivo RNA Structurome Reveals RNA Secondary Structure Conservation and Divergence in Plants显示文摘RNA 第二等的结构在基因规定起一个关键作用。瑞斯(Oryza sativa ) 是在世界上的最重要的食物庄稼之一。然而,在米饭的 RNA 结构几乎没被学习。这里,我们成功地产生了在 ? 在米饭的 vivo Structure-seq 图书馆。我们发现 mRNAs 的结构的灵活性可能与生物功能的动力学联系。更高的 N 6-methyladenosine (m 6 一) 修正趋于在 3 UTR 有更少的 RNA 结构,而 GC 内容显著地不影响在 ? 维持象翻译那样的有效生物过程的 vivo mRNA 结构。在米饭和 Arabidopsis 之间的 RNA structurome 的比较分析揭示了内容不导致的那更高的 GC 更强壮的结构和更少 RNA 结构的灵活性。而且,我们发现了在顺序和在米饭和 Arabidopsis 之间的 orthologs 的结构保存之间的弱关联。顺序并且在的保存和分叉 ? vivo RNA 结构对应于多样、特定的生物过程。我们的结果显示那 RNA 第二等的结构可能把选择的分开的层提供给在 monocot 和 dicot 之间的顺序。因此,我们的学习暗示那 RNA 结构在各种各样的生物进程不同地演变在被子植物进化期间在开发和 adaptational 灵活性维持坚韧性。 | Hongjing Deng Jitender Cheema Hang Zhang Hugh Woolfenden Matthew Norris Zhenshan Liu Qi Liu Xiaofei Yang Minglei Yang Xian Deng Xiaofeng Cao Yiliang Ding | 2018 | Molecular Plant2018，11，4： | 2 |
| 13 | First Discovery of Hadean Xenocrystal Zircons from Granitic Gneisses in the Northern Dabie Orogen显示文摘Objective Geological records of Earth history in the Hadean(>4.0 Ga)are critical for understanding the earliest evolution of the planet’s continental crust.Unfortunately,investigation of such proto-continental crust,including its formation mechanism and evolution,has been extremely limited due to the scarcity of Hadean terranes,because most ancient crustal records have been destroyed during subsequent geological processes. | QIU Xiaofei DENG Xin JIANG Tuo XU Qiong YANG Wenwu | 2021 | Acta Geologica Sinica(English Edition)2021，95，5： | 2 |
| 14 | Document Clustering Using Locality Preserving Indexing显示文摘 | Cai Deng He Xiaofei Han Jiawei | 2005 | Knowledge and Data Engineering2005，17，12： | 1 |
| 15 | Squeezer: an efficient algorithm for clustering categorical data显示文摘 | HE Zengyou XU Xiaofei DENG Shengchun | 2002 | Jounranl of Computer Science and Technology2002，17，5： | 1 |
| 16 | Discove- ring cluster based local outliers 显示文摘 | HE Zengyou XU Xiaofei DENG Shengchun | 2003 | Pattern Recognition Letters2003，24，： | 1 |
| 17 | Graph Regularized Non-negative Matrix Factorization for Data Representation 显示文摘 | CAI Deng HE Xiaofei HAN Jiawei | 2011 | IEEE Trans Pattern Anal Maeh Intel2011，33，8： | 1 |
| 18 | Discovering cluster based local outliers 显示文摘 | He Zengyou Xu Xiaofei Deng Shengchun | 2003 | Pattern Recognition Letters2003，24，910： | 1 |
| 19 | Neighborhood preserving embedding显示文摘 | Xiaofei He Deng Cai Shuicheng Yan Hong-Jiang Zhang | 2005 | Tenth IEEE international conference on computer vision(5)2005，，： | 1 |
| 20 | Orthogonal Laplacianfaces for face recognition 显示文摘 | CAI Deng HE Xiaofei HAN Jiawei | 2006 | IEEE Transactions on Image Processing2006，，15： | 1 |
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