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		题名	作者	年代	出处	被引量
	1	Ran binding protein 9(RanBPM) binds IFN-λR1 in the IFN-λsignaling pathway显示文摘Like the type I interferons(IFNs),the recently discovered cytokine IFN-λ displays antiviral,antiproliferative,and proapoptotic activities,mediated by a heterodimeric IFN-λ receptor complex composed of a unique IFN-λR1 chain and the IL-10R2 chain.However,the molecular mechanism of the IFN-λ-regulated pathway remains unclear.In this study,we newly identified RAN-binding protein M(RanBPM) as a binding partner of IFN-λR1.The interaction between RanBPM and IFN-λRl was identified with a glutathione S-transferase pull-down assay and coimmunoprecipitation experiments.IFN-λ1 stimulates this interaction and affects the cellular distribution of RanBPM.However,the interaction between RanBPM and IFN-λR1 does not correlate with their conserved TRAF6-binding sites.Furthermore,we also found that RanBPM is a scaffolding protein with a modulatory function that regulates the activities of IFN-stimulated response elements.Therefore,RanBPM plays a novel role in the IFN-λ-regulated signaling pathway.	Junwen Zhang XiaojieCong Jiajie Zhaoqiao Xia Yang Meng Li Hong Chen Ruifang Mi Guishan Jin Fusheng Liu Bing-Ren Huang	2017	Science China(Life Sciences)2017，60，9：	1

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