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| 1 | Occurrence and removal of N-nitrosodimethylamine and its precursors in wastewater treatment plants in and around Shanghai显示文摘六废水处理植物(WWTP ) 被调查评估出现和移动 N-nitrosodimethylamine (NDMA ) , NDMA 形成潜力(FP ) 和四位特定的 NDMA 先锋, dimethylamine (直接存储器存取) , trimethylamine (TMA ) , dimethylformamide (DMFA ) 和 dimethylaminobenzene (DMAB ) 。与直接存储器存取功能的组一起的直接存储器存取和第三级的胺通常在市政的废水存在。化学上提高的主要过程(CEPP ) 没在 NDMA 或 NDMA FP 的移动上有效果。在有第二等的处理过程的 WWTP,可观的可变性在 NDMA (19%85%) 和 NDMA FP (16%76%) 的移动被观察,而且,在 NDMA 和 NDMA FP 的移动之间没有明确的关系。直接存储器存取很好在所有六调查 WWTP 被移开;它的移动效率比 97% 大。为第三级的胺的移动,生物学的处理与氮的硝化作用和 denitrification 处理移动效率最好比常规激活的污泥处理。为 TMA, DMFA 和 DMAB 的最好的移动效率分别地是 95% , 68% 和 72% 。CEPP 能移开 73% TMA, 23% DMFA 和 36% DMAB。在紫外消毒以后,仅仅, 17% NDMA 由于低剂量被移开紫外在 WWTP 被使用。尽管氯化能减少 NDMA 先锋, NDMA 集中实际上在氯化以后被增加。 | Lin WANG Yongmei LI Xiaoling SHANG Jing SHEN | 2014 | Frontiers of Environmental Science & Engineering2014，8，4： | 7 |
| 2 | Effects of Yishendaluo decoction on axonal degeneration,inflammatory reaction,and neurological function in a mouse model of experimental autoimmune encephalomyelitis显示文摘<正>BACKGROUND:Yishendaluo decoction reduces production of inflammatory mediators,relieves damage due to inflammatory reactions,and improves neural functions during experimental autoimmune encephalomyelitis. OBJECTIVE:To investigate the effects of Yishendaluo decoction on a mouse model of experimental autoimmune encephalomyelitis. DESIGN,TIME AND SETTING:The randomized,controlled,neuropathological,and molecular biological animal study was performed at the Key Laboratory of Chinese Internal Medicine,Ministry of Education,Dongzhimen Hospital of Beijing University of Chinese Medicine and Center for Neuroinformatics,General Hospital of Chinese PLA from 2005 to 2006. MATERIALS:Yishendaluo decoction pieces consisting of prepared rehmannia root,colla cornus cervi,cape jasmine fruit,and grassleaf sweetflag rhizome were purchased from the Dongzhimen Hospital of Beijing University of Chinese Medicine.Rabbit anti-mouseβ-amyloid precursor protein and p38 polyclonal antibody(Zhongshan Goldenbridge Biotechnology,China),as well interferon-γand interleukin-4 ELISA kit(Boster,China),were used in this study. METHODS:A total of 96 healthy,female,SJL/J mice,aged 8-12 weeks,were equally and randomly assigned to normal,model,hormone,and Chinese medicine groups.A total of 0.2 mL antigen preparation,supplemented with 150μg PLP139-151 and 400μg H37RA,was subcutaneously injected into the upper abdomen of mice from the model,hormone,and Chinese medicine groups. Mouse models of experimental autoimmune encephalomyelitis were established by intravenous injection of 0.1 mL Bordetella pertussis solution containing 0.6×10~6 Bordetella pertussis at days 1 and 3.Mice from the model,Chinese medicine,and hormone groups were respectively subjected to 0.2 mL saline,2 g/kg Yishendaluo decoction,and 0.078 mg/kg prednisone acetate,once daily for 14 consecutive days.Mice from the normal group were left intact. MAIN OUTCOME MEASURES:Pathological changes were observed using hematoxylin-eosin staining and Luxol fast blue staining.Expression ofβ-amyloid precursor protein and p38 protein was determined by immunohistochemistry.Levels of interferon-γand interleukin-4 were detected by ELISA.Behavioral changes were assessed in mice according to scores of neurological function. RESULTS:A few inflammatory cell infiltration,nerve fiber breakage and slight demyelination were detected in the central nervous system of mice from the Chinese medicine and hormone groups compared with the model group.Expression ofβ-amyloid precursor protein and p38 protein was significantly diminished in the central nervous system of mice from the Chinese medicine and hormone groups compared with the model group(P<0.05 or P<0.01),and the decrease was greatest in the Chinese medicine group.The decrease in mouse weight was not significant,and neurological function scores were less in the Chinese medicine and hormone groups compared with the model group(P<0.05 or P<0.01).Interferon-γlevels were significantly reduced(P<0.01),and interleukin-4 levels were significantly increased(P<0.01) in the brains of the Chinese medicine and hormone groups,compared with the model group. CONCLUSION:Yishendaluo decoction improved neurological function in mice with experimental autoimmune encephalomyelitis by downregulatingβ-amyloid precursor protein expression,resisting axonal degeneration,and relieving inflammatory reaction.The anti-inflammatory mechanism was regulated by inhibition of the p38 mitogen-activated protein kinase signal pathway. | Xiaoling Shang Ying Gao Ling Yin Jintao Zhang Shuoren Wang | 2009 | Neural Regeneration Research2009，4，11： | 6 |
| 3 | A new method to identify and improve the purity of hybrid rice with herbicide resistant gene显示文摘There is a dose relationship between the hybrid rice production and seed purity, Two-line bybrid rice with bigher beterosis is produced through the hybridization between a photothermo sensitive genetic male sterile (GMS) rice line and a paternat variety, But the fertilety of photo-thermo sensitive GMS rice line is not stable because it changes with the total climate. | HUANG Danian,ZHANG Shanging,XUE Rui,HUA Zhihua,XIU Xiaobo,and WANG Xiaoling,CNRRI,Hangzhou 310006,China | 1998 | Chinese Rice Research Newsletter1998，6，1： | 3 |
| 4 | Effect of Dangfei Liganning capsule(当飞利肝宁胶囊) on liver X receptor α/steroid regulatory element binding protein-1/fatty acid synthase signal pathway in rats with metabolic-associated fatty liver disease显示文摘OBJECTIVE: To study the mechanism of Dangfei Liganning capsule(当飞利肝宁胶囊) in the treatment of rats with metabolic associated fatty liver disease(MAFLD). METHODS: Totally 48 specific pathogen free SpragueDawley male rats were randomly divided into normal Group, model group, Dangfei Liganning high, moderate, and low-dose groups and Essentiale group which were fed with high fat diet for 8 weeks, and gavage and molding were carried out simultaneously. Dangfei Liganning high, middle and low-dose group were given 0.27, 0.135 and 0.0675 g·kg-1·d-1 respectively by gavage, Essentiale group was given 0.123 g·kg-1·d-1 by gavage, the same amount of distilled water was given by gavage in the normal group and the model group. The rats were weighed at the 0th week, 2nd week, 4th week, 6th week and 8th weekend respectively. The rats were sacrificed at the end of the 8th week. Serum levels of alanine aminotransferase(ALT), alanine aminotransferase(AST),triglyceride(TG), total cholesterol(CHO), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein (LDL-C), total protein(TP), albumin(Alb), globulin(GLB), total bilirubin(TBIL), direct bilirubin(DBIL), tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) were measured. The levels of liver tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and liver pathology [hematoxylin and eosin(HE) staining, oil red O staining] were detected. The expression levels of liver X receptor α(LXRα), steroid regulatory element binding protein-1(SREBP-1) and fatty acid synthase(FAS) were detected by immunohistochemistry, Western blot and reverse transcription-polymerase chain reaction reverse transcription-polymerase chain reaction. RESULTS: From the beginning to the 8th week, the growth rate of body weight in the Dangfei Liganning highdose group was slower than all other groups. There was no significant difference in ALB level in all groups(P > 0.05). Compared with the model group, the levels of ALT, AST, LDL-C, TG, CHO, TP, GLB, TBIL, DBIL, IL-6, TNF-α were significantly decreased and HDL-C were significantly increased in Dangfei Liganning high-dose group(P < 0.01, < 0.05). HE and oil red O staining showed that the fatty lesions in rat liver were alleviated, while the expressions of LXRα, SREBP-1, FAS m RNA and protein were significantly decreased(P < 0.01). CONCLUSIONS: Dangfei Liganning capsule can slow down the increase of body weight of MAFLD rats, reduce the levels of transaminase, Lipid and inflammatory factors in MAFLD rats, promote the synthesis of liver protein and bile metabolism, and improve the liver fatty lesion of MAFLD rats, among which the Dangfei Liganning highdose group is more effective. The mechanism of action may be through blocking LXR-SREBP-1-FAS signal pathway. | LI Xiaoling SUN Fengxia SHANG Zimeng ZHANG Yingxue LI Jie ZHANG Qiuxiang | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 2 |
| 5 | Oxidative coupling of cinnamic acid derivatives and their radical-scavenging activities显示文摘4-Hydroxycinnamic acid derivatives,including ferulic acid (FA) (1),sinapic acid (SA) (2) and caffeic acid (CA) (3),are widely distributed in the plant kingdom,and undergo oxidative cross-coupling leading to the corresponding dehydrodimers,trimers and even higher oligomers in plants. In order to evaluate the antioxidative ability of these 4-hydroxycinnamic acid derivatives and their oligomers,we synthesized 8-8'-bis-lactone-dimers (8-8'-DiFA (4),8-8'-DiSA (5) and 8-8'-DiCA (6)),as well as a new trimer (7),by the reaction of the corresponding monomers (1-3) with Ag2O in methanol,and assayed their free radical-scavenging activity by the reaction with 2,2-diphenyl-1-picrylhydrazyl radical (DPPH·). It was found that CA (3) and 8-8'-DiCA (6) bearing o-dihydroxyl groups exhibited significantly higher radical-scavenging activity than those bearing no such groups,and oxidative coupling of CA (3) resulted in remarkable enhancement in the activity. | JIN XiaoLing YANG RuTing SHANG YaJing DAI Fang QIAN YiPing CHENG LiXia ZHOU Bo LIU ZhongLi | 2010 | Chinese Science Bulletin2010，55，25： | 2 |
| 6 | α‐Smooth muscle actin‐positive myofibroblasts, in association with epithelial–mesenchymal transition and lymphogenesis, is a critical prognostic parameter in patients with oral tongue squamous cell carcinoma显示文摘 | Lei Ding Ziwen Zhang Duo Shang Jie Cheng Hua Yuan Yunong Wu Xiaoling Song Hongbing Jiang | 2014 | J Oral Pathol Med2014，，5： | 1 |
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