|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ultrasmall Fe<sub>3</sub>O<sub>4</sub> Nanoparticle/MoS<sub>2</sub> Nanosheet Composites with Superior Performances for Lithium Ion Batteries显示文摘 | Yu Chen Bohang Song Xiaosheng Tang Li Lu Junmin Xue | 2014 | Small2014，，8： | 1 |
| 2 | Ultrasmall Fe3O4 nanoparticle /MoS2 nanosheet com- posites with superior performances for lithium ion bat- teries显示文摘 | CHE Yu SONG Bohang TANG Xiaosheng | 2014 | Small2014，10，8： | 1 |
| 3 | Mixed H2/H∞distributed robust model predictive control for poly-topic uncertain systems subject to actuator saturation and missing measurements显示文摘 | YAN Song Xiaosheng Fang Qingda Diao | 2015 | International Journal of Systems Science2015，47，4： | 1 |
| 4 | Establishment of NaLuF_(4):15%Tb-based low dose X-PDT agent and its application on efficient antitumor therapy显示文摘X-ray excited photodynamic therapy(X-PDT)is the bravo answer of photodynamic therapy(PDT)for deep-seated tumors,as it employs X-ray as the irradiation source to overcome the limitation of light penetration depth.However,high X-ray irradiation dose caused organ lesions and side effects became the major barrier to X-PDT application.To address this issue,this work employed a classic-al co-precipitation reaction to synthesize NaLuF_(4):15%Tb^(3+)(NLF)with an average particle size of(23.48±0.91)nm,which was then coupled with the photosensitizer merocyanine 540(MC540)to form the X-PDT system NLF-MC540 with high production of singlet oxygen.The system could induce antitumor efficacy to about 24%in relative low dose X-ray irradiation range(0.1-0.3 Gy).In vivo,when NLF-MC540 irradiated by 0.1 Gy X-ray,the tumor inhibition percentage reached 89.5%±5.7%.The therapeutic mechanism of low dose X-PDT was found.A significant increase of neutrophils in serum was found on the third day after X-PDT.By immunohistochemical staining of tumor sections,the Ly6G^(+),CD8^(+),and CD11c^(+)cells infiltrated in the tumor microenvironment were studied.Utilizing the bilat-eral tumor model,the NLF-MC540 with 0.1 Gy X-ray irradiation could inhibit both the primary tumor and the distant tumor growth.De-tected by enzyme linked immunosorbent assay(ELISA),two cytokines IFN-γand TNF-αin serum were upregulated 7 and 6 times than negative control,respectively.Detected by enzyme linked immune spot assay(ELISPOT),the number of immune cells attributable to the IFN-γand TNF-αlevels in the group of low dose X-PDT were 14 and 6 times greater than that in the negative control group,respectively.Thus,it conclude that low dose X-PDT system could successfully upregulate the levels of immune cells,stimulate the secretion of cy-tokines(especially IFN-γand TNF-α),activate antitumor immunity,and finally inhibit colon tumor growth. | Yi Tian Zhiguang Fu Xiaosheng Zhu Chunjing Zhan Jinwei Hu Li Fan Chaojun Song Qian Yang Yu Wang Mei Shi | 2024 | International Journal of Minerals,Metallurgy and Materials2024，31，3： | 0 |
| 5 | Decomposition pathway and stabilization of ether-based electrolytes in the discharge process of Li-O_(2) battery显示文摘Ether-based electrolytes with relatively high stability are widely used in Li-O_(2) batteries (LOBs) with high energy density.However,they are still prone to be attacked by reactive oxygen species.Understanding the degradation chemistry of ether-based solvent induced by reactive oxygen species is significant importance toward selection of stable electrolytes for LOBs.Herein,we demonstrate that a great amount of H_(2) gas evolves on the Li anode during the long-term discharge process of LOBs,which is due to the electrolyte decomposition at the oxygen cathode.By coupling with in-situ and ex-situ characterization techniques,it is demonstrated that O_(2)^(-) induces the H-abstraction of tetraethylene glycol dimethyl ether(TEGDME) to produce a large amount of H_(2)O at cathode,and this H_(2)O migrates to Li anode and produce H_(2) gas.Based on the established experiments and spectra,a possible decomposition pathway of TEGDME caused by O_(2)^(-)at the discharge process is proposed.And moreover,three types of strategies are discussed to inhibit the decomposition of ether-based electrolytes,which should be highly important for the fundamental and technical advancement for LOBs. | Xiao Liu Xiaosheng Song Qi Zhang Xuebing Zhu Qing Han Zewen Liu Peng Zhang Yong Zhao | 2022 | Journal of Energy Chemistry2022，31，6： | 0 |
| 6 | An Experience of On-site PD Testing for Condition Monitoring of an 11 kV PILC Cable Insulation System显示文摘 | Xiaosheng Peng Chengke Zhou Xiaodi Song | 2012 | Journal of Energy and Power Engineering2012，6，1： | 0 |
| 7 | Fano resonance-enhanced Si/MoS_(2) photodetector显示文摘In this work,a Si∕MoS_(2) heterojunction photodetector enhanced by hot electron injection through Fano resonance is developed.By preparing Au oligomers using capillary-assisted particle assembly(CAPA)on the silicon substrate with a nanohole array and covering few-layer MoS_(2) with Au electrodes on top of the oligomer structures,the Fano resonance couples with a Si∕MoS_(2) heterojunction.With on-resonance excitation,Fano resonance generated many hot electrons on the surface of oligomers,and the hot electrons were injected into MoS_(2),providing an increased current in the photodetector under a bias voltage.The photodetectors exhibited a broadband photoresponse ranging from 450 to 1064 nm,and a large responsivity up to 52 A/W at a wavelength of 785 nm under a bias voltage of 3 V.The demonstrated Fano resonance-enhanced Si∕MoS_(2) heterojunction photodetector provides a strategy to improve the photoresponsivity of two-dimensional materials-based photodetectors for optoelectronic applications in the field of visible and near-infrared detection. | TIANXUN GONG BOYUAN YAN TAIPING ZHANG WEN HUANG YUHAO HE XIAOYU XU SONG SUN XIAOSHENG ZHANG | 2023 | Photonics Research2023，11，12： | 0 |
| 8 | A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors显示文摘Protein arginine methyltransferases(PRMTs)are attractive targets for developing therapeutic agents,but selective PRMT inhibitors targeting the cofactor SAM binding site are limited.Herein,we report the discovery of a noncanonical but less polar SAH surrogate YD1113 by replacing the benzyl guanidine of a pan-PRMT inhibitor with a benzyl urea,potently and selectively inhibiting PRMT3/4/5.Importantly,crystal structures reveal that the benzyl urea moiety of YD1113 induces a unique and novel hydrophobic binding pocket in PRMT3/4,providing a structural basis for the selectivity.In addition,YD1113 can be modified by introducing a substrate mimic to form a“T-shaped”bisubstrate analogue YD1290 to engage both the SAM and substrate binding pockets,exhibiting potent and selective inhibition to typeⅠPRMTs(IC_(50)<5 nmol/L).In summary,we demonstrated the promise of YD1113 as a general SAH mimic to build potent and selective PRMT inhibitors. | Youchao Deng Xiaosheng Song Iredia D.Iyamu Aiping Dong Jinrong Min Rong Huang | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 9 | Hyparillums A and B: polycyclic polyprenylated acylphloroglucinols from Hypericum patulum显示文摘Hyparillums A(1)and B(2),two previously unidentified polycyclic polyprenylated acylphloroglucinols(PPAPs)with intricate architectures,were isolated from Hypericum patulum Thunb.Hyparillum A was the first PPAP with eight-carbon rings based on an unprecedented 6/6/5/6/6/5/6/4 octocyclic system featuring a rare heptacyclo[10.8.1.11,10.03,8.08,21.012,19.014,17]docosane core.In contrast,hyparillum B featured a novel heptacyclic architecture(6/6/5/6/6/5/5)based on a hexacyclo[9.6.1.11,9.03,7.07,18.011,16]nonadecane motif.Furthermore,hyparillums A and B demonstrated promising inhibitory effects on the proliferation of murine splenocytes stimulated by anti-CD3/anti-CD28 monoclonal antibodies and lipopolysaccharide,exhibiting half-maximal inhibitory concentration(IC50)values ranging from 6.13±0.86 to 12.69±1.31μmol·L−1. | DUAN Yulin SHI Zhengyi SONG Fei HOU Zhangrong TAN Xiaosheng ZHANG Yeting HAO Xincai CHEN Gang QI Changxing ZHANG Yonghui | 2024 | Chinese Journal of Natural Medicines2024，22，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员