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| 1 | Advanced hydrogels for the repair of cartilage defects and regeneration显示文摘Cartilage defects are one of the most common symptoms of osteoarthritis(OA),a degenerative disease that affects millions of people world-wide and places a significant socio-economic burden on society.Hydrogels,which are a class of biomaterials that are elastic,and display smooth surfaces while exhibiting high water content,are promising candidates for cartilage regeneration.In recent years,various kinds of hydrogels have been developed and applied for the repair of cartilage defects in vitro or in vivo,some of which are hopeful to enter clinical trials.In this review,recent research findings and developments of hydrogels for cartilage defects repair are summarized.We discuss the principle of cartilage regeneration,and outline the requirements that have to be fulfilled for the deployment of hydrogels for medical applications.We also highlight the development of advanced hydrogels with tailored properties for different kinds of cartilage defects to meet the requirements of cartilage tissue engineering and precision medicine. | Wei Wei Yuanzhu Ma Xudong Yao Wenyan Zhou Xiaozhao Wang Chenglin Li Junxin Lin Qiulin He Sebastian Leptihn Hongwei Ouyang | 2021 | Bioactive Materials2021，6，4： | 8 |
| 2 | Fabric changes induced by super-absorbent polymer on cementelime stabilized excavated clayey soil显示文摘This paper studies the microstructure variation induced by super-absorbent polymer(SAP)to understand the mechanism of macroscopic strength improvement of stabilized soil.The fabric changes of cement elime stabilized soil were analyzed with respect to the variation of SAP content,water content,lime content and curing time,using mercury intrusion porosimetry(MIP)tests.It can be observed that the delimitation pore diameter between inter-and intra-aggregate pores was 0.2 mm for the studied soil,determined through the intrusion/extrusion cycles.Experimental results showed that fabric in both inter-and intra-aggregate pores varied significantly with SAP content,lime content,water content and curing time.Two main changes in fabric due to SAP are identified as:(1)an increase in intra-aggregate pores(<0.2 mm)due to the closer soilecementelime cluster space at higher SAP content;and(2)a decrease in inter-aggregate pores represented by a reduction in small-pores(0.2e2 mm)due to the lower pore volume of soil mixture after water absorption by SAP,and a slight increase in large-pores(>2 mm)due to the shrinkage of SAP particle during the freezeedry process of MIP test.Accordingly,the strength gain due to SAP for cementelime stabilized soil was mainly due to a denser fabric with less interaggregate pores.The cementitious products gradually developed over time,leading to an increase in intra-aggregate pores with an increasing proportion of micro-pores(0.006e0.2 mm).Meanwhile,the inter-aggregate pores were filled by cementitious products,resulting in a decrease in total void ratio.Hence,the strength development over time is attributable to the enhancement of cementation bonding and the refinement of fabric due to the increasing cementitious compounds. | Xia Bian Lingling Zeng Xiaozhao Li Xiusong Shi Shuming Zhou Fuqing Li | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，5： | 3 |
| 3 | A roughness parameter considering joint material properties and peak shear strength model for rock joints显示文摘This study aims at proposing a reasonable roughness parameter that can reflect the peak shear strength(PSS)of rock joints.Firstly,the contribution of the asperities with different apparent dip angles to shear strength is studied.Then the shear strength of the entire joint asperities is derived.The results showed that the PSS of the entire joint asperities is proportional to a key parameter hs,which is related to the geometric character of the joint surface and the joint material properties.The parameter hsis taken as the new roughness parameter,and it is reasonable to associate the PSS with the geometric characteristics of the joint surface.Based on the new roughness parameter and shear test results of 20 sets of joint specimens,a new PSS model for rock joints is proposed.The new model is validated with the artificial joints in this paper and real rock joints in published studies.Results showed that it is suitable for different types of rock joints except for gneiss joints.The new model has the form of the Mohr-Coulomb model,which can directly reflect the relationship between the 3 D roughness parameters and the peak dilation angle. | Liren Ban Weisheng Du Tianwei Jin Chengzhi Qi Xiaozhao Li | 2021 | International Journal of Mining Science and Technology2021，31，3： | 3 |
| 4 | An integrated planning concept for the emerging underground urbanism: Deep City Method Part 2 case study for resource supply and project valuation显示文摘 | Li Huanqing Li Xiaozhao Parriaux Aurèle | 2013 | Tunnelling and Underground Space Technology2013，38，6： | 1 |
| 5 | Evolution laws of microstructures and mechanical properties during heat treatments for near-αhigh-temperature titanium alloys显示文摘Evolution laws of microstructures,mechanical properties,and fractographs after different solution temperatures were investigated through various analysis methods.With the increasing solution temperatures,contents of the primaryαphase decreased,and contents of transformedβstructures increased.Lamellarαgrains dominated the characteristics of transformedβstructures,and widths of secondaryαlamellas increased monotonously.For as-forged alloy,large silicides with equiaxed and rod-like morphologies,and nano-scale silicides were found.Silicides with large sizes might be(Ti,Zr,Nb)_(5)Si_(3) and(Ti,Zr,Nb)_(6)Si_(3).Rod-like silicides with small sizes precipitated in retainedβphase,exhibiting near 45°angles withα/βboundaries.Retainedβphases in as-heat treated alloys were incontinuous.980STA exhibited an excellent combination of room temperature(RT)and 650°C mechanical properties.Characteristics of fracture surfaces largely depended on the evolutions of microstructures.Meanwhile,silicides promoted the formation of mico-voids. | Xiaozhao Ma Zhilei Xiang Tao Li Yilan Chen Yingying Liu Ziyong Chen Qun Shu | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，8： | 1 |
| 6 | Deformation characteristics and novel strain criteria of strainbursts induced by low-frequency cyclic disturbance显示文摘Strainbursts induced by cyclic disturbance with low frequency(termed as cyclicinduced strainbursts)are major dynamic disasters during deep excavation and mining.There is currently no quantitative criterion available for the prediction of such disastrous events.In this study,based on true triaxial experiments,we analyzed the deformation characteristics,established two novel strain criteria for the cyclic-induced strainbursts,and explained the physical meaning of these criteria.Characteristic strains for the cyclic-induced strainbursts were defined,including the control strain ε_(ctr),the strain caused by the combined dynamic and static loading ε_(sd),and the ultimate strain ε_(u) after strainbursts.As indicated by the results,the deformation evolution of the cyclic-induced strainbursts shows remarkable fatigue characteristics,which resemble that of rock subjected to cyclic loading and unloading.In other words,there are three stages during deformation evolution,namely,initial rapid growth,uniform velocity growth after several periods of disturbance,and sudden sharp growth preceding the burst.The ultimate strain ε_(u) is insensitive to the tangential static stress and disturbance amplitude,but it changes nonlinearly with disturbance frequency.From the perspective of deformation,the occurrence of a cyclic-induced strainburst is controlled by the control strainε_(ctr).Thus,a control strain criterion is proposed;that is,when the stain ε_(sd) is larger than the control strain ε_(ctr),a strainburst will be induced by cyclic disturbance.Moreover,based on the statistical results,a strain ratio criterion is proposed;that is,when the strain ratio ε_(sd)/ε_(u) is greater than 30%,a cyclic-induced strainburst will be induced. | Lihua Hu Minghe Ju Peng Zhao Xiaozhao Li | 2023 | Deep Underground Science and Engineering2023，2，1： | 1 |
| 7 | Three-dimensional geo- logical modeling based on division of engineering geological stra- ta units显示文摘 | Cao Liang Li Xiaozhao Tacher L | 2012 | Advanced Science Letters2012，5，2： | 1 |
| 8 | Estimates of strength and cracking behaviors of pre-flawed granite specimens treated by chemical corrosion under triaxial compression tests显示文摘Four types of granite specimens were prepared and treated by chemical corrosion for 5 and 30 days,which were then used to carry out triaxial compression tests under different confining pressuresσ_(3).Type A is the intact sample with no preexisting flaws.Types B and C are the samples containing two relatively low-dip flaws and two relatively high-dip flaws,respectively.Type D is the sample including both relatively low-dip and relatively high-dip flaws.The influences of pH value of chemical solutions,flaw distribution,corrosion time andσ_(3) on triaxial stress-strain curves and ultimate failure modes are analyzed and discussed.The results show that the pH value of the chemical solution,corrosion time and the arrangement of preexisting flaws play crucial roles in the cracking behaviors of granite specimens.Type A specimens have the largest peak axial deviatoric stress,followed by Type C,Type D,and Type B specimens,respectively.It is because the decrease in the inclination of preexisting flaws induces the weakening effect due to the decrease in the shadow area along the compaction direction.Under aσ_(3) of 5 MPa,the peak axial deviatoric stress drops by approximately 40.89%,29.08%,4.08%,and 23.53%for pH=2,4,7,and 12,respectively.For intact granite(Type A)specimens,the ultimate failure mode displays a typical shear mode.The connection of two secondary cracks initiated at the tips of preexisting cracks is always the ultimate failure and crack coalescence mode for Type B specimens.The ultimate failure and crack coalescence mode of Types C and D specimens are significantly affected by pH value of the chemical solution,corrosion time andσ_(3),which is different from those of Types A and B specimens due to the differences in flow distributions. | Zhicong LI Richeng LIU Shuchen LI Hongwen JING Xiaozhao LI Liyuan YU | 2022 | Frontiers of Earth Science2022，16，2： | 1 |
| 9 | Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosis显示文摘 | Yongqian Bian Li Wang Huanyu Lu Guodong Yang Zhang Zhang Haiyan Fu Xiaozhao Lu Mengying Wei Jianyong Sun Qingchuan Zhao Guanglong Dong Zifan Lu | 2012 | Biochemical and Biophysical Research Communications2012，，1： | 1 |
| 10 | Effects of intermediate stress on deep rock strainbursts under true triaxial stresses显示文摘The effect of intermediate stress(in situ tunnel axial)on a strainburst is studied with a threedimensional(3D)bonded block distinct element method(DEM).A series of simulations of strainbursts under true triaxial in situ stress conditions(i.e.high tangential stress,moderate intermediate stress and low radial stress)of near-boundary rock masses are performed.Compared with the experimental results,the DEM model is able to capture the stress-strain response,failure pattern and energy balance of strainbursts.The fracturing processes of strainbursts are also numerically reproduced.Numerical results show that,as the intermediate stress increases:(1)The peak strain of strainbursts increases,the yield stress increases,the rock strength increases linearly,and the ratio of yield stress to rock strength decreases,indicating that the precursory information on strainbursts is enhanced;(2)Tensile and shear cracks increase significantly,and slabbing and bending of rock plates are more pronounced;and(3)The stored elastic strain energy and dissipated energy increase linearly,whereas the kinetic energy of the ejected rock fragments increases approximately exponentially,implying an increase in strainburst intensity.By comparing the experimental and numerical results,the effect of intermediate stress on the rock strength of strainbursts is discussed in order to address three key issues.Then,the Mogi criterion is applied to construct new strength criteria for strainbursts by converting the one-face free true triaxial stress state of a strainburst to its equivalent true triaxial stress state.In summary,the effect of intermediate stress on strainbursts is a double-edged sword that can enhance the rock strength and the precursory information of a strainburst,but also increase its intensity. | Lihua Hu Liyuan Yu Minghe Ju Xiaozhao Li Chun’an Tang | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，3： | 1 |
| 11 | RESEARCH ON COLOR CONSTANCY UNDER OPEN ILLUMINATION CONDITIONS显示文摘Color information plays a key role in the research fields of object recognition and image retrieval. However, the actual color varies by the conditions of illumination, especially the open natural daylight. Four different color constancy schemes are proposed in the paper to minimize the effects of open illumination conditions. (1) The color constancy scheme based on the image statistics is proposed, which includes the color cast detection and removal. (2) The color constancy scheme based on the color temperature curve is proposed, which combines Gaussian model with linear fitting to estimate color temperature curve. (3) The color constancy scheme based on the double exposure theory is proposed, which is able to reproduce a color image under typical illumination. (4) According to the concepts of supervised learning, the supervised color constancy scheme is proposed. The transformation of color values from unknown illumination to typical illumination is solved by improved Support Vector Regression (SVR). | Xu Xiaozhao Zhuo Li Zhang Jing Shen Lansun | 2009 | Journal of Electronics(China)2009，26，5： | 1 |
| 12 | Constructing oxygen-deficient V_(2)O_(3)@C nanospheres for high performance potassium ion batteries显示文摘Potassium ion batteries(PIBs) have been regarded as promising alternatives to lithium ion batteries(LIBs)on account of their abundant resource and low cost in large scale energy storage applications. However,it still remains great challenges to explore suitable electrode materials that can reversibly accommodate large size of potassium ions. Here, we construct oxygen-deficient V_(2)O_(3)nanoparticles encapsulated in amorphous carbon shell(Od-V_(2)O_(3)@C) as anode materials for PIBs by subtly combining the strategies of morphology and deficiency engineering. The MOF derived nanostructure along with uniform carbon coating layer can not only enables fast K+migration and charge transfer kinetics, but also accommodate volume change and maintain structural stability. Besides, the introduction of oxygen deficiency intrinsically tunes the electronic structure of materials according to DFT calculation, and thus lead to improved electrochemical performance. When utilized as anode for PIBs, Od-V_(2)O_(3)@C electrode exhibits superior rate capability(reversible capacities of 262.8, 227.8, 201.5, 179.8, 156.9 mAh/g at 100, 200, 500, 1000 and2000 mA/g, respectively), and ultralong cycle life(127.4 mAh/g after 1000 cycles at 2 A/g). This study demonstrates a feasible way to realize high performance PIBs through morphology and deficiency engineering. | Qiang Deng Luolan Wang Jing Li Qian Cheng Xiaozhao Liu Changdong Chen Qimeng Zhang Wentao Zhong Hua Wang Lijue Wu Chenghao Yang | 2023 | Chinese Chemical Letters2023，34，3： | 0 |
| 13 | Evolution of Desertification Types on the North Shore of Qinghai Lake显示文摘Land desertification is a widely concerned ecological environment problem.Studying the evolution trend of desertification types is of great significance to prevent and control land desertification.In this study,we applied the decision tree classification method,to study the land area and temporal and spatial change law of different types of desertification in the North Bank of Qinghai Lake area from 1987 to 2014,based on the current land use situation and TM remote sensing image data of Haiyan County,Qinghai Province,The results show that the area of mild desertification land and moderate desertification land in the study area has decreased,while the area of severe desertification land and extreme desertification land has increased significantly in the past 30 years.The area of desertification land decreased by 4.02 km2,of which the area of mild and moderate desertification land decreased by 39.73 km2 and 36.8 km2 respectively,and the area of severe and extreme desertification land increased by 32.78 km2 and 39.73 km2 respectively.As for the mutual transformation relationship,the transformation from severe desertification land to extreme desertification land is the main,and the junction of severe desertification land and extreme desertification land is the sensitive area of transformation.In the north shore of Qinghai Lake,the sandy land tends to expand eastward.The research provides reference basis for local land desertification monitoring,and has a great guidance for local effective land desertification and soil and water conservation. | Wenzheng Yu Jintao Cui Yang Gao Mingxuan Zhu Li Shao Yanbo Shen Xiaozhao Zhang Chen Guo Hanxiaoya Zhang | 2022 | Computers, Materials & Continua2022，，5： | 0 |
| 14 | New understandings on initiation and evolution of disasters in deep underground显示文摘The editors wish to highlight the articles appearing in this issue.The first article,entitled“New physics of supersonic ruptures”by Boris G.Tarasov,concerns the development of a new theory on the potential occurrence of ruptures after deep underground earthquakes.Two other articles belong to our first special theme of“Disaster evolution in deep underground.”The final two articles introduce a nonlocal damage fracture phasefield model for rock‐like materials and the gas–liquid displacement in microcleats for mass transfer through gas‐or water‐driven displacement.These five papers indeed explore various aspects of deep underground science and engineering and constitute an integral component of deep underground fundamentals. | Jianguo Wang Heping Xie Chunfai Leung Xiaozhao Li | 2023 | Deep Underground Science and Engineering2023，2，3： | 0 |
| 15 | A research on excavation compensation theory for large deformation disaster control and a review on the multiphysical-multiscale responses of salt rock for underground gas storage显示文摘We highlight two articles in this issue:A research article titled“Excavation compensation theory and supplementary technology system for large deformation disasters”by Manchao He et al.and a review article titled“Mineralogy,microstructures and geomechanics of rock salt for underground gas storage”by Veerle Vandeginste et al. | Jianguo Wang Heping Xie Chunfai Leung Xiaozhao Li | 2023 | Deep Underground Science and Engineering2023，2，2： | 0 |
| 16 | An Analytical Method for Predicting Direct Tensile Creep Fracture in Brittle Solids Containing Initial Microcracks显示文摘The tensile creep fracture behaviors in brittle solids are of great significance for the safety evaluation of brittle solid engineering.However,micromechanics-based tensile creep fracture behavior is rarely studied.In this study,a micromechanics-based method for predicting direct tensile creep fractures is presented.This method is established by combining the suggested expression of the mode-I stress intensity factor,the subcritical crack growth law,and the relationship between wing crack length and axial strain.This suggested mode-I stress intensity factor is formulated by the use of the basic theory of fracture mechanics under different loading modes.The rationality of the proposed tensile creep fracture model is verified by comparing with the experimental results.The correspondences of time-dependent axial strain,strain rate,wing crack length,and crack velocity are plotted under constant stress and stepping stress during tensile creep fracture.The effects of the initial crack size,inclination angle and density on the crack initiation stress,tensile strength,tensile creep fracture time,steady-state strain rate,initial strain,crack coalescence strain,and failure strain are discussed. | Xiaozhao Li Chengzhi Qi | 2022 | Acta Mechanica Solida Sinica2022，35，1： | 0 |
| 17 | Quantitative two/three-dimensional spatial characterization and fluid transport prediction of macro/micropores in Gaomiaozi bentonite显示文摘The sealing performance of a bentonite barrier is highly dependent on its seepage characteristics, which are directly related to the characteristics of its pore structure. Based on scanning electron microscopy(SEM) and focused ion beam-SEM(FIB-SEM), the pore structure of bentonite was characterized at different scales. First, a reasonable gray threshold was determined through back analysis, and the image was binarized based on the threshold. In addition, binary images were used to analyze bentonite’s pore structure(porosity and pore size distribution). Furthermore, the effects of different algorithms on the pore structure characterization were evaluated. Then, permeability calculations were performed based on the previous pore structure characteristics and a modified permeability prediction model. For permeability prediction based on the three-dimensional model, the effect of pore tortuosity was also considered. Finally, the accuracy of numerical calculations was verified by conducting macroscopic gas and alcohol permeability experiments. This approach provides a better understanding of the microscale mechanism of gas transport in bentonite and the importance of pore structures at different scales in determining its seepage characteristics. | Jiangfeng Liu Shijia Ma Hongyang Ni Hai Pu Xiaozhao Li Shaojie Chen | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，5： | 0 |
| 18 | Exploration of Water Resource and Multiple Model for Water Resource Development in Karst Areas with the Preferred Plane Theory显示文摘According to the theory of preferred plane, preferred planes (faults) always control the distribution of bedrock fissure water and hold abundant groundwater. Thus, the exploration of fissure or karst water can be converted into searching for the watery preferred plane (WPP). In the paper, the characteristic of watery preferred planes is analyzed and a series of superior indices has been set up. It is introduced that WPPs are determined by the methods of geological analysis, superior index and complex geophysical analysis. Meanwhile, new multiple model for water resource development in the water-scarce areas of karst mountainous regions are advanced. | LUO Guoyu, YAN Changhong, LI Xiaozhao, JIANG Jianping and MA Ji Department of Earth Sciences, Nanjing University, Nanjing, Jiangsu 210093 | 2003 | Acta Geologica Sinica(English Edition)2003，77，1： | 0 |
| 19 | Dynamic photoelectrical regulation of ECM protein and cellular behaviors显示文摘Dynamic regulation of cell-extracellular matrix(ECM)-material interactions is crucial for various biomedical applications.In this study,a light-activated molecular switch for the modulation of cell attachment/detachment behaviors was established on monolayer graphene(Gr)/n-type Silicon substrates(Gr/Si).Initiated by light illumination at the Gr/Si interface,pre-adsorbed proteins(bovine serum albumin,ECM proteins collagen-1,and fibronectin)underwent protonation to achieve negative charge transfer to Gr films(n-doping)throughπ-πinteractions.This n-doping process stimulated the conformational switches of ECM proteins.The structural alterations in these ECM interactors significantly reduced the specificity of the cell surface receptor-ligand interaction(e.g.,integrin recognition),leading to dynamic regulation of cell adhesion and eventual cell detachment.RNA-sequencing results revealed that the detached bone marrow mesenchymal stromal cell sheets from the Gr/Si system manifested regulated immunoregulatory properties and enhanced osteogenic differentiation,implying their potential application in bone tissue regeneration.This work not only provides a fast and feasible method for controllable cells/cell sheets harvesting but also gives new insights into the understanding of cell-ECM-material communications. | Xiaozhao Wang Cai Yao Xudong Yao Junxin Lin Rui Li Kun Huang Weiming Lin Xiaojun Long Chao Dai Jiajun Dong Xuegong Yu a Wenwen Huang Wenjian Weng Qi Wang Hongwei Ouyang Kui Cheng | 2023 | Bioactive Materials2023，，4： | 0 |
| 20 | Preliminary study on the determination of the Weibull modulus of strength distribution in quasi-brittle materials显示文摘In this paper,how to determine the Weibull modulus of a fracture strength distribution is discussed with its physical implications for quasi-brittle materials.Based on the Markov chain assumption,it is shown that the lifetime(i.e.,the time taken for formation of a critical defect)in a quasi-brittle material can be described by a gamma probabilistic distribution function.Prior to macroscopic failure,the effective number of energy barriers to be overcome is determined by the slope of the energy barrier spectrum,which is equivalent to the Weibull modulus.Based on a fracture mechanics model,the fracture energy barrier spectral slope and Weibull modulus can be calculated theoretically.Furthermore,such a model can be extended to take into account the crack interactions and defect-induced degradation.The predicted Weibull modulus is good agreement with that derived from available experimental results. | Chengzhi Qi Chunsheng Lu A.I.Chanyshev Xiaozhao Li Xiaolei Qu | 2023 | Geohazard Mechanics2023，1，2： | 0 |
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