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| 1 | Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks显示文摘Avian infectious bronchitis virus(IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune system. Severe histopathological lesions were observed in the tracheal mucosa at 3–5days post inoculation(dpi) and in the kidney at 8 dpi, with heavy viral loads at 1–11 and 1–28 dpi,respectively. The expression of m RNAs encoding Toll-like receptor(TLR) 3 and TLR7 were upregulated at 3–8 dpi, and that of TIR-domain-containing adapter-inducing interferon(IFN) β(TRIF) was upregulated at 21 dpi in the trachea and kidney. Myeloid differentiation primary response protein 88(My D88) was upregulated in the trachea during early infection. Tumor necrosis factor receptor-associated factor(TRAF) 3 and TRAF6 were upregulated expression in both tissues.Moreover, melanoma differentiation-associated protein 5(MDA5), laboratory of genetics and physiology 2(LGP2), stimulator of IFN genes(STING), and mitochondrial antiviral signaling protein(MAVS), as well as TANK binding kinase 1(TBK1), inhibitor of kappa B kinase(IKK) ?, IKKα, IKKβ,IFN regulatory factor(IRF) 7, nuclear factor of kappa B(NF-κB), IFN-α, IFN-β, various interleukins(ILs), and macrophage inflammatory protein-1β(MIP-1β) were significantly upregulated in the trachea and downregulated in the kidney. These results suggested that the TLR and MDA5 signaling pathways and innate immune cytokine were induced after IBV infection. Additionally,consistent responses to IBV infection were observed during early infection, with differential and complicated responses in the kidney. | Yining He Zhiwen Xie Jinglong Dai Yanjie Cao Jinlian Hou Yansheng Zheng Tianchao Wei Meilan Mo Ping Wei | 2016 | Virologica Sinica2016，31，1： | 14 |
| 2 | Organocatalytic domino reaction of electron-deficient 2,4-dienes with 2-halo-1,3-dicarbonyl com- pounds:A highly regio- and stereoselective approach to functionalized five-membered carbocycles显示文摘 | Xie Jianwu Xu Meilan Zhang Renzun | 2014 | Chem Inform2014，45，33： | 1 |
| 3 | Research on first heart sound and second heart sound amplitude variability and reversal phenomenon-A new finding in athletic heart study显示文摘 | Wu Wenzhu Guo Xingming Xie Meilan | 2009 | Journal of Medical and Biological Engineering2009，29，4： | 1 |
| 4 | Research on First Heart Sound and Second Heart Sound Amplitude Variability and Reversal Phenomenon-A New Finding in Athletic Heart Study显示文摘 | WU Wenzhu GUO Xingming XIE Meilan | 2009 | Journal of Medical and Biological Engineering2009，29，4： | 1 |
| 5 | Multi-center, Multi-topic Heart Sound Databases and Their Applications显示文摘 | XIE MEILAN XIAO SHOUZHONG LIU TIANHU | 2010 | J Med Systems2010，36，1： | 1 |
| 6 | Decoration of carbon encapsulated nitrogen-rich MoxN with few-layered MoSe2 nanosheets for high-performance sodium-ion storage显示文摘Transition metal nitrides have become the focus of research in sodium ion batteries(SIBs)due to their unique metal properties and high theoretical capacity.However,the low actual capacity is still the main bottleneck for their application.Herein,using Mo-aniline frameworks as precursors,the carbon encapsulated nitrogen-rich Mo_(x)N is decorated by few-layered MoSe_(2) nanosheets(MoSe_(2)@Mo_(x)N/C-I)after the facile calcinating,selenizing,and nitriding.The carbon encapsulation can effectively strengthen the structural stability of Mo_(x)N.The nitrogen-rich Mo_(x)N and decoration of few-layered MoSe_(2) can create rich heterointerfaces and extra active sites for rapid sodium-ion storage,thus promoting reaction kinetics and improving actual capacity.The MoSe_(2)@Mo_(x)N/C-I as an anode achieves a large reversible capacity of 522.8 mAh g^(-1)at 0.1 A g^(-1),and 254.3 mAh g^(-1)capacity is obtained after 6000 cycles at 5.0 A g^(-1),showing signally improved sodium-ion storage properties.The storage mechanisms and kinetic behaviors are described systematically via the advanced testing techniques and density functional theory(DFT)calculations.It is found that the nitrogen-rich Mo_(x)N as the substrate is the basis of long cycling stability,and the few-layered MoSe_(2) are the key to improving actual capacity.This work indicates that the decoration of few-layered selenides has a broad application prospect in high-performance metal-ion batteries. | Tao Lu Baoquan Liu Fanyan Zeng Guo Cheng Shile Chu Meilan Xie Zhi Chen Zhaohui Hou | 2022 | Journal of Energy Chemistry2022，31，11： | 0 |
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