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您的检索式：作者名="Xindong Shui"
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| 1 | Error Estimate of a Fully Discrete Local Discontinuous Galerkin Method for Variable-Order Time-Fractional Diffusion Equations显示文摘The aim of this paper is to develop a fully discrete local discontinuous Galerkin method to solve a class of variable-order fractional diffusion problems.The scheme is discretized by a weighted-shifted Grünwald formula in the temporal discretization and a local discontinuous Galerkin method in the spatial direction.The stability and the L^(2)-convergence of the scheme are proved for all variable-orderα(t)∈(0,1).The proposed method is of accuracy-order O(τ^(3)+h^(k+1)),whereτ,h,and k are the temporal step size,the spatial step size,and the degree of piecewise P^(k)polynomials,respectively.Some numerical tests are provided to illustrate the accuracy and the capability of the scheme. | Leilei Wei Shuying Zhai Xindong Zhang | 2021 | Communications on Applied Mathematics and Computation2021，3，3： | 0 |
| 2 | Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer’s disease显示文摘Background:Intracellular accumulation of the microtubule-associated protein tau and its hyperphosphorylated forms is a key neuropathological feature of Alzheimer’s disease(AD).Melatonin has been shown to prevent tau hyperphosphorylation in cellular and animal models.However,the molecular mechanisms by which melatonin attenuates tau hyperphosphorylation and tau-related pathologies are not fully understood.Methods:Immunofluorescence,immunoblotting analysis and thioflavin-S staining were employed to examine the effects of early and late treatment of melatonin on tau-related pathology in hTau mice,in which nonmutated human tau is overexpressed on a mouse tau knockout background.High-throughput microRNA(miRNA)sequencing,quantitative RT-PCR,luciferase reporter assay and immunoblotting analysis were performed to determine the molecular mechanism.Results:We found that both early and late treatment of melatonin efficiently decreased the phosphorylation of soluble and insoluble tau at sites related to AD.Moreover,melatonin significantly reduced the number of neurofibrillary tangles(NFTs)and attenuated neuronal loss in the cortex and hippocampus.Furthermore,using miRNA microarray analysis,we found that miR-504-3p expression was upregulated by melatonin in the hTau mice.The administration of miR-504-3p mimics dramatically decreased tau phosphorylation by targeting p39,an activator of the well-known tau kinase cyclin-dependent kinase 5(CDK5).Compared with miR-504-3p mimics alone,co-treatment with miR-504-3p mimics and p39 failed to reduce tau hyperphosphorylation.Conclusions:Our results suggest for the first time that melatonin alleviates tau-related pathologies through upregulation of miR-504-3p expression by targeting the p39/CDK5 axis and provide novel insights into AD treatment strategies. | Dongmei Chen Guihua Lan Ruomeng Li Yingxue Mei Xindong Shui Xi Gu Long Wang Tao Zhang Chen-Ling Gan Yongfang Xia Li Hu Yuan Tian Mi Zhang Tae Ho Lee | 2022 | Translational Neurodegeneration2022，11，1： | 0 |
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