维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

4篇 您的检索式：作者名="Xingang Weng"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Curcumin-incorporated 3D bioprinting gelatin methacryloyl hydrogel reduces reactive oxygen species-induced adipose-derived stem cell apoptosis and improves implanting survival in diabetic wounds显示文摘Background:Gelatin methacryloyl(GelMA)hydrogels loaded with stem cells have proved to be an effective clinical treatment for wound healing.Advanced glycation end product(AGE),interacting with its particular receptor(AGER),gives rise to reactive oxygen species(ROS)and apoptosis.Curcumin(Cur)has excellent antioxidant activity and regulates intracellular ROS production and apoptosis.In this study,we developed a Cur-incorporated 3D-printed GelMA to insert into adiposederived stem cells(ADSCs)and applied it to diabetic wounds.Methods:GelMA hydrogels with Cur were fabricated and their in vitro effects on ADSCs were investigated.We used structural characterization,western blot,ROS and apoptosis assay to evaluate the antioxidant and anti-apoptotic activity,and assessed the wound healing effects to investigate the mechanism underlying regulation of apoptosis by Cur via the AGE/AGER/nuclear factor-κB(NF-κB)p65 pathway.Results:A 10%GelMA scaffold exhibited appropriate mechanical properties and biocompatibility for ADSCs.The circular mesh structure demonstrated printability of 10%GelMA and Cur-GelMA bioinks.The incorporation of Cur into the 10%GelMA hydrogel showed an inhibitory effect on AGEs/AGER/NF-κB p65-induced ROS generation and ADSC apoptosis.Furthermore,Cur-GelMA scaffold promoted cell survival and expedited in vivo diabetic wound healing.Conclusions:The incorporation of Cur improved the antioxidant activity of 3D-printed GelMA hydrogel and mitigated AGE/AGER/p65 axis-induced ROS and apoptosis in ADSCs.The effects of scaffolds on wound healing suggested that Cur/GelMA-ADSC hydrogel could be an effective biological material for accelerating wound healing.	Sizhan Xia Tingting Weng Ronghua Jin Min Yang Meirong Yu Wei Zhang Xingang Wang Chunmao Han	2022	Burns & Trauma2022，10，1：	4
	2	Analysis of 020 Model'sDevelopment Problems and Trend显示文摘	Xingang Weng Liying Zhang	2015	iBusiness2015，7，1：	1
	3	Analysis of 020 Model's Development Problems and Trend 显示文摘	Xingang Weng Liying Zhang	2015	iBusiness2015，，7：	1
	4	Nanomaterials for the delivery of bioactive factors to enhance angiogenesis of dermal substitutes during wound healing显示文摘Dermal substitutes provide a template for dermal regeneration and reconstruction.They constitutes an ideal clinical treatment for deep skin defects.However,rapid vascularization remains as a major hurdle to the development and application of dermal substitutes.Several bioactive factors play an important regulatory role in the process of angiogenesis and an understanding of the mechanism of achieving their effective delivery and sustained function is vital.Nanomaterials have great potential for tissue engineering.Effective delivery of bioactive factors(including growth factors,peptides and nucleic acids)by nanomaterials is of increasing research interest.This paper discusses the process of dermal substitute angiogenesis and the roles of related bioactive factors in this process.The application of nanomaterials for the delivery of bioactive factors to enhance angiogenesis and accelerate wound healing is also reviewed.We focus on new systems and approaches for delivering bioactive factors for enhancing angiogenesis in dermal substitutes.	Tingting Weng Jialiang Wang Min Yang Wei Zhang Pan Wu Chuangang You Chunmao Han Xingang Wang	2022	Burns & Trauma2022，10，1：	0

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费