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| 1 | Amplitude of low-frequency fluctuations on Alzheimer’s disease with depression: evidence from resting-state fMRI显示文摘Background The prevalence of Alzheimer's disease(AD)comorbid with depression is common.However,the mechanisms of AD with depression remain unclear.Aims To investigate the regional alterations of brain activity of AD with depression in resting-state functional magnetic resonance imaging(rs-fMRI).Methods 154 patients with AD who met the inclusion criteria were recruited from the Zhejiang Provincial People’s Hospital from October 2014 to October 2016.According to whether the core symptoms of depression were present,patients were divided into two groups,22 patients with AD with depression(AD-D)and 52 patients with AD without depression(AD-nD).The amplitude of low frequency fluctuations(ALFF)was compared between two groups by performing independent-samples f-test.Results Compared with the AD-D group,increased ALFF values in the bilateral superior frontal gyrus,left middle frontal gyrus and left inferior frontal gyrus were observed in the AD-nD group.The brain activity in the AD-nD group in the bilateral superior frontal gyrus,left middle frontal gyrus and the left inferior frontal gyrus was higher than the AD-D group.Conclusions Resting-state brain functional alterations may be closely bound up with the pathophysiologic features of patients with AD with depressive symptoms. | Yuzhu Mu Yumei Li Qi Zhang Zhongxiang Ding Mei Wang Xingguang Luo Xiaoyun Guo Maosheng Xu | 2020 | General Psychiatry2020，33，4： | 1 |
| 2 | 酒精依赖的基于基因和基于通路的全基因组关联研究(英文)显示文摘背景:信号通路中风险基因的构成可能可以解释酒精依赖风险基因协同的神经生物学作用。目的:识别酒精依赖的风险基因和风险基因通路。方法:我们采用基因富集(gene-set-rich)分析方法对酒精依赖进行了基于通路的全基因组关联分析(GWAS)。在包括1409名欧裔美国人(European-American,EA)酒精依赖者和1518名EA健康对照者的探索性样本人群中检测了近一百万个基因标志物。此外,将681名非裔美国人(African-American,AA)病例和508名AA健康受试者作为重测样本。结果:我们发现了几个与酒精依赖显著相关的可重复的全基因组风险基因和风险通路。在多重比较Bonferroni校正后,'细胞-细胞外基质相互作用'通路(EA样本中p<2.0E-4)和该通路中PXN基因(编码桩蛋白paxillin)(EA样本中p=3.9E-7)是最有可能的酒精依赖的危险因素。在EA样本(0.015≤p≤0.035)和AA样本(0.025≤p≤0.050)中还有两条富含酒精依赖相关基因的可重复的通路:'Na+/Cl-依赖性神经递质转运体'通路和'其他聚糖降解'通路。结论:一些基因和生物信号传导过程可能与酒精依赖的风险相关,本研究的发现为此提供了新的证据。 | Lingjun ZUO Clarence K.ZHANG Frederick G.SAYWARD Kei-Hoi CHEUNG Kesheng WANG John H.KRYSTAL Hongyu ZHAO Xingguang LUO | 2015 | 上海精神医学2015，27，2： | 1 |
| 3 | Flow and Heat Transfer Instability of Supercritical Carbon Dioxide in a Vertical Heated Tube显示文摘Supercritical carbon dioxide(S-CO_(2))is one of the most promising working fluids in energy conversion systems.However,the instability of the flow and heat transfer has caused great harm to the security of energy conversion systems.In this work,a transient model based on the Finite Volume Method is set up to investigate the flow and heat transfer instability of CO_(2) changing from a subcritical state to a supercritical state in a vertical heated circular tube.The instability occurs when the wall heat flux is higher than a critical value,which makes the density and mass flow rate variations large enough.A large variation of the density triggers self-sustained oscillations in the flow.The critical heat flux heightens with the higher inlet pressure and pressure drop,larger tube diameter,and lower inlet temperature,but it reduces with the lengthening of the tube.To reflect the density-variation degree for the corresponding heat flux,a dimensionless number N_(tpc)=qπDL/Mβ_(pc)(p)/C_(p,pc)(p)(trans-pseudocritical number)is introduced.The critical trans-pseudocritical number Ntpc,c first goes up and down with the increase of the inlet pressure and the reduction of the inlet temperature.The rise of the mass flow rate,the shortening of the tube length,and the enlargement of the tube diameter all induce the temperature difference along the radial direction to become large.These tendencies make the critical Ntpc,c small.Consequently,the stability boundary N_(tpc,c)=48.47(N_(psc))^(1.048)(Δp∗)^(0.359)(D/L)^(−0.026)(G∗)^(−0.335)(ρ∗)^(2.666) is obtained to distinguish the regions of the flow and heat transfer stability and instability. | WANG Zhibin LIANG Xingguang CHEN Ying LUO Xianglong | 2023 | Journal of Thermal Science2023，32，4： | 0 |
| 4 | Aetiology of bipolar disorder: contribution of the L-type voltage-gated calcium channels显示文摘LTCCS ARE IMPLICATED IN THE PATHOLOGY OF BIPOLAR DISORDER Bipolar disorder (BPD) is a common mental illness with significant morbidity and mortality.1 Although evidence have suggested changes in oxidative stress, dopamine and inflammation in BPD, it is hard to define the aetiological mechanism of BPD clearly. Recently, some but not all candidate gene association studies, family-based association studies, linkage studies, genome-wide association studies (GWASs) and meta-analyses showed that mutation of L-type voltage-gated calcium chan? nels (LTCCs) gene CACNAlCis implicated in the mechanism of BPD.'-8 These findings support the possibility that BPD might have calcium channelopathy. | Xiaoyun Guo Dengtang Liu Tong Wang Xingguang Luo | 2019 | General Psychiatry2019，32，3： | 0 |
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