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		题名	作者	年代	出处	被引量
	1	Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe显示文摘Salt-inducible kinase 2 (SIK2) is a member of the AMP-activated serine/threonine kinase family. It has been reported that inhibition of SIK2 can enhance the cytotoxicity of paclitaxel,1 promote premitotic apoptosis, and lead to cell cycle arrest in the metaphase.2 Thus, targeting SIK2 may be a therapeutic strategy for cancers drug and radiotherapy resistance. Mitotic catastrophe is a type of abnormal mitosis leading to cell death characterized by the multipolar spindle and multinucleation, which was first discovered during an ionizing radiation (IR)-induced cell damage.3 However, the mechanism of mitotic catastrophe is not well understood. The present study aimed to assess the effect of the knockdown of SIK2 on IR-induced mitotic catastrophe.	Jiaojiao Zhu Ying Zhang Ziyan Yan Jianxiao Wang Ping Wang Xinxin Liang Yuhao Liu Xingkun Ao Maoxiang Zhu Pingkun Zhou Yongqing Gu	2023	Genes & Diseases2023，10，2：	0

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