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| 1 | Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression显示文摘Neurogenesis decline in hippocampal dentate gyrus(DG)participates in stress-induced depressive-like behaviors,but the underlying mechanism remains poorly understood.Here,we observed low-expression of NOD-like receptor family pyrin domain containing 6(NLRP6)in hippocampus of stress-stimulated mice,being consistent with high corticosterone level.NLRP6 was found to be abundantly expressed in neural stem cells(NSCs)of DG.Both Nlrp6 knockout(Nlrp6^(-/-))and NSCconditional Nlrp6 knockout(Nlrp6CKO)mice were susceptible to stress,being more likely to develop depressive-like behaviors.Interestingly,NLRP6 was required for NSC proliferation in sustaining hippocampal neurogenesis and reinforcing stress resilience during growing up.Nlrp6 deficiency promoted esophageal cancer-related gene 4(ECRG4)expression and caused mitochondrial dysfunction.Corticosterone as a stress factor significantly down-regulated NLRP6 expression,damaged mitochondrial function and suppressed cell proliferation in NSCs,which were blocked by Nlrp6 overexpression.ECRG4 knockdown reversed corticosterone-induced NSC mitochondrial function and cell proliferation disorders.Pioglitazone,a well-known clinical drug,up-regulated NLRP6 expression to inhibit ECRG4 expression in its protection against corticosterone-induced NSC mitochondrial dysfunction and proliferation restriction.In conclusion,this study demonstrates that NLRP6 is essential to maintain mitochondrial homeostasis and proliferation in NSCs,and identifies NLRP6 as a promising therapeutic target for hippocampal neurogenesis decline linked to depression. | Chuanfeng Tang Qiaona Wang Jingyan Shen Congying Wang Hong Ding Shiyu Wen Fan Yang Ruiqing Jiao Xingxin Wu Jianmei Li Lingdong Kong | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 2 | Effects of sludge characteristics on electrical resistance and energy consumption during electro-dewatering process显示文摘The increase of electrical resistance(ER)and energy consumption(EC)during the later stage of dewatering is a major problem hindering the development of electro-dewatering(EDW)technology.As the variations of sludge characteristics are significant during the EDW process,the relationships between sludge characteristics and ER and EC during EDW remain unclear.In this study,the effects of moisture content(MC),thickness,pH,conductivity,zeta potential,temperature,and gas volume on the ER and EC during the EDW process were statistically investigated using correlation and multiple linear regression analyses.Herein,the results showed that the ER of the sludge near the anode was primarily affected by pH,whereas the sludge near the cathode was primarily affected by the MC and conductivity.Further,sludge temperature and conductivity were the most reliable indicators to predict the EC near the anode and cathode,respectively.The results of this study provide theoretical guidance useful for solving the increase of ER and EC during the later stage of the EDW process. | Li Sha Xiaoyan Yu Zhangxiang Wu Xingxin Liu Shuting Zhang | 2021 | Journal of Environmental Sciences2021，33，3： | 2 |
| 3 | Locally differentially private distributed algorithms for set intersection and union显示文摘Dear editor,Privacy-preserving distributed set intersection and union(PPSI, PPSU) have received much attention in recent years because of their wide applications. Most of existing solutions [1, 2] utilize secure multiparty computation protocols(SMCP) [3, 4] to settle the problem, but the SMCP methods are expensive in computation and communication. Even worse, most SMCP methods hardly continue to work if some participants disconnect. | Qiao XUE Youwen ZHU Jian WANG Xingxin LI Ji ZHANG | 2021 | Science China(Information Sciences)2021，64，11： | 1 |
| 4 | Fully distributed identity-based threshold signatures with identifiable aborts显示文摘Identity-based threshold signature(IDTS)is a forceful primitive to protect identity and data privacy,in which parties can collaboratively sign a given message as a signer without reconstructing a signing key.Nevertheless,most IDTS schemes rely on a trusted key generation center(KGC).Recently,some IDTS schemes can achieve escrow-free security against corrupted KGC,but all of them are vulnerable to denial-of-service attacks in the dishonest majority setting,where cheaters may force the protocol to abort without providing any feedback.In this work,we present a fully decentralized IDTS scheme to resist corrupted KGC and denialof-service attacks.To this end,we design threshold protocols to achieve distributed key generation,private key extraction,and signing generation which can withstand the collusion between KGCs and signers,and then we propose an identification mechanism that can detect the identity of cheaters during key generation,private key extraction and signing generation.Finally,we formally prove that the proposed scheme is threshold unforgeability against chosen message attacks.The experimental results show that the computation time of both key generation and signing generation is<1 s,and private key extraction is about 3 s,which is practical in the distributed environment. | Yan JIANG Youwen ZHU Jian WANG Xingxin LI | 2023 | Frontiers of Computer Science2023，17，5： | 0 |
| 5 | Quantitative analysis of collagen morphology in breast cancer from millimeter scale using multiphoton microscopy显示文摘The tumor microenvironment(TME)is now recognized as an important participant of tumor progression.As the most abundant extracellular matrix component in TME,collagen plays an important role in tumor development.The imaging study of collagen morphological feature in TME is of great significance for understanding the state of tumor.Multiphoton microscopy(MPM),based on second harmonic generation(SHG)and two-photon excitation fluorescence(TPEF),can be used to monitor the morphological changes of biological tissues without labeling.In this study,we used MPM for large-scale imaging of early invasive breast cancer from the tumor center to normal tissues far from the tumor.We found that there were signi¯cant di®erences in collagen morphology between breast cancer tumor boundary,near tumor transition region and normal tissues far from the tumor.Furthermore,the morphological feature of eight collagen¯bers was extracted to quantify the variation trend of collagen in three regions.These results may provide a new perspective for the optimal negative margin width of breast-conserving surgery and the understanding of tumor metastasis. | Yulan Liu Shunwu Xu Deyong Kang Xingxin Huang Shuoyu Xu Lianhuang Li Liqin Zheng Lida Qiu Zhenlin Zhan Xiahui Han Jianxin Chen | 2023 | Journal of Innovative Optical Health Sciences2023，16，4： | 0 |
| 6 | Optical second-harmonic generation imaging for identifying gastrointestinal stromal tumors显示文摘Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors arising in the digest tract.It brings a challenge to diagnosis because it is asymptomatic clinically.It is well known that tumor development is often accompanied by the changes in the morphology of collagen fibers.Nowadays,an emerging optical imaging technique,second-harmonic generation(SHG),can directly identify collagen fibers without staining due to its noncentrosymmetric properties.Therefore,in this study,we attempt to assess the feasibility of SHG imaging for detecting GISTs by monitoring the morphological changes of collagen fibers in tumor microenvironment.We found that collagen alterations occurred obviously in the GISTs by comparing with normal tissues,and furthermore,two morphological features from SHG images were extracted to quantitatively assess the morphological difference of collagen fibers between normal muscular layer and GISTs by means of automated image analysis.Quantitative analyses show a significant difference in the two collagen features.This study demonstrates the potential of SHG imaging as an adjunctive diagnostic tool for label-free identification of GISTs. | Shichao Zhang Xingxin Huang Deyong Kang Jikui Miao Zhenlin Zhan Guoxian Guan Jianxin Chen Yongjian Zhou Lianhuang Li | 2023 | Journal of Innovative Optical Health Sciences2023，16，5： | 0 |
| 7 | The novel SLC40A1(T419I)variant results in a loss-of-function phenotype and may provide insights into the mechanism of large granular lymphocytic leukemia and pure red cell aplasia显示文摘Variants in the solute carrier family 40 member 1(SLC40A1)gene are the molecular basis of ferroportin disease,which is an autosomal dominant hereditary hemochromatosis.Here,we present a patient with pure red cell aplasia(PRCA)and large granular lymphocytic leukemia(LGLL)associated with an extremely high levels of serum ferritin and iron overload syndrome.Whole exon sequencing revealed a novel heterozygous variant in SLC40A1(p.T419I),which was found in his daughter as well.A series of functional studies in vitro of the T419I variant in ferroportin were conducted and the results revealed a reduced capacity of iron export from cells without changes in protein localization and its sensitivity to hepcidin.Intracellular iron storage in mutated cells was significantly higher than that of wild-type.These findings suggest that the novel variant p.T419I can cause the classical form of ferroportin disease and an elevated intracellular iron level indicates a potential novel pathogenic mechanism underlying PRCA and LGLL. | Hongfei Wu Xiang Ren Meili Ge Peiyuan Dong Shichong Wang Huiming Yi Xingxin Li Jiali Huo Xuan Zheng Mengying Gao Jinbo Huang Jing Zhang Min Wang Peng Jin Neng Nie Yingqi Shao Yizhou Zheng | 2022 | Blood Science2022，4，1： | 0 |
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