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您的检索式：作者名="Xinshui Zhang"
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| 1 | The ZFP541-KCTD19 complex is essential for pachytene progression by activating meiotic genes during mouse spermatogenesis显示文摘Meiosis is essential for fertility in sexually reproducing species and this sophisticated process has been extensively studied.Notwithstanding these efforts,key factors involved in meiosis have not been fully characterized.In this study,we investigate the regulatory roles of zinc finger protein 541(ZFP541)and its interacting protein potassium channel tetramerization domain containing 19(KCTD19)in spermatogenesis.ZFP541 is expressed from leptotene to the round spermatid stage,while the expression of KCTD19 is initiated in pachytene.Depletion of Zfp541 or Kctd19 leads to infertility in male mice and delays progression from early to mid/late pachynema.In addition,Zfp541^(-/-)spermatocytes show abnormal programmed DNA double-strand break repair,impaired crossover formation and resolution,and asynapsis of the XY chromosomes.ZFP541 interacts with KCTD19,histone deacetylase 1/2(HDAC1/2),and deoxynucleotidyl transferase terminal-interacting protein 1(DNTTIP1).Moreover,ZFP541 binds to and activates the expression of genes involved in meiosis and post-meiosis including Kctd19;in turn,KCTD19 promotes the transcriptional activation activity of ZFP541.Taken together,our studies reveal that the ZFP541/KCTD19 signaling complex,acting as a key transcription regulator,plays an indispensable role in male fertility by regulating pachytene progression. | Yushan Li Ranran Meng Shanze Li Bowen Gu Xiaotong Xu Haihang Zhang Xinshui Tan Tianyu Shao Jiawen Wang Dan Xu Fengchao Wang | 2022 | Journal of Genetics and Genomics2022，49，11： | 0 |
| 2 | Ultrafast Carbonized Wood of Electrode-Scaled Aligned-Porous Structure for High-Performance Lithium Batteries显示文摘The use of carbonized wood in various functional devices is attracting considerable attention due to its low cost,vertical channels,and high electrical conduction.However,the conventional carbonization method requires a long processing time and an inert atmosphere.Here,a microwave-assisted ultrafast carbonization technique was developed that carbonizes natural wood in seconds without the need for an inert atmosphere,and the obtained aligned-porous carbonized wood provided an excellent electrochemical performance as an anode material for lithium-ion batteries.This ultrafast carbonization technique simultaneously produced ZnO nanoparticles during the carbonization process that were uniformly distributed on the alignedporous carbon.The hierarchical structure of carbonized wood functionalized with ZnO nanoparticles was used as a host for achieving high-performance lithium-sulfur batteries:the highly conductive carbonized wood framework with vertical channels provided good electron transport pathways,and the homogeneously dispersed ZnO nanoparticles effectively adsorbed lithium polysulfide and catalyzed its conversion reactions.In summary,a new method was developed to realize the ultrafast carbonization of biomass materials with decorated metal oxide nanoparticles. | Shaojie Chen Lu Nie Hongsheng Shi Xiangchen Hu Zeyu Wang Xinshui Zhang Yuyao Zhang Qilin Hu Tianyi Gao Yi Yu Wei Liu | 2023 | Transactions of Tianjin University2023，29，5： | 0 |
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