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您的检索式：作者名="Xinwang Yuan"
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| 1 | FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers显示文摘forkhead 盒子抄写因素 A2 (FOXA2 ) 是在动物开发和身体动态平衡的一个重要管理者。然而, FOXA2 是否涉及转变生长因素尾 1 (TGF-尾 1 ) ,调停了 epithelial-to-mesenchymal 转变(EMT ) 和肿瘤转移仍然保持未知。现在的学习证明在人的肺癌症房间线,许多 FOXA2 断然与上皮的显型相关并且否定地与房间的间充质的显型相关,并且 TGF-尾 1 治疗减少了 FOXA2 蛋白质水平。一致地, FOXA2 击倒肺癌症房间的支持的 EMT 和侵略,而 FOXA2 的 overexpression 减少了侵略并且压制了 TGF- ,尾 1 导致了 EMT。另外, FOXA2 击倒禁止的 FOXA2 的导致的蛞蝓表示,和宫外的表示猛击抄写。而且,我们鉴别 FOXA2 能绑通过一个保存有约束力的地点猛击倡导者,并且 FOXA2 的 DNA 有约束力的区域和 transactivation 区域 II 为蛞蝓倡导者的压抑被要求。这些数据证明 FOXA2 由 EMT 的抑制作为肿瘤转移的 suppressor 工作。 | Yunneng Tang Guangwen Shu Xinwang Yuan Naihe Jing Jianguo Song | 2011 | Cell Research2011，21，2： | 27 |
| 2 | Glucocorticoid receptor–IRS-1 axis controls EMT and the metastasis of breast cancers显示文摘Glucocorticoid receptor (GR) is involved in the transcriptional regulation of genes that are important for various biological functions, including tumor growth and metastatic progression. However, the cellular and biological effects of GR remain poorly understood. Here, we investigated the role of GR and its underlying mechanism in mediating breast cancer cell survival and metastasis. We observed that the GR levels were increased in drug-resistant breast cancer cells and in metastatic breast cancer samples. GR promoted tumor cell invasion and lung metastasis in vivo. The GR expression levels were negatively correlated with the survival rates of breast cancer patients. Both ectopic expression and knockdown of GR revealed that GR is a strong inducer of epithelial-to-mesenchymal transition (EMT), which is consistent with its effects on cell survival and metastasis. GR suppressed the expression of insulin receptor substrate 1 (IRS-1) by acting as an IRS-1 transcriptional repressor. In addition, GR has an opposite effect on the expression levels of IRS-2, indicating that GR is able to differentially regulate the IRS-1 and IRS-2 expression. The cellular and biological effects elicited by GR were consistent with the reduced levels of IRS-1 observed in cancer cells, and GR-mediated IRS-1 suppression activated the ERK2 MAP kinase pathway, which is required for GR-mediated EMT. Taken together, our results indicate that GR–IRS-1 signaling axis plays an essential role in regulating the survival, invasion, and metastasis of breast cancer cells. | Weiwei Shi Dongmei Wang Xinwang Yuan Yi Liu Xiaojie Guo Jingsong Li Jianguo Song | 2019 | Journal of Molecular Cell Biology2019，11，12： | 1 |
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