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| 1 | Novel dental implant modifications with two-staged double benefits for preventing infection and promoting osseointegration in vivo and in vitro显示文摘Peri-implantitis are a major problem causing implant failure these days.Accordingly,anti-infection during the early stage and subsequent promotion of osseointegration are two main key factors to solve this issue.Micro-arc oxidation(MAO)treatment is a way to form an oxidation film on the surface of metallic materials.The method shows good osteogenic properties but weak antibacterial effect.Therefore,we developed combined strategies to combat severe peri-implantitis,which included the use of a novel compound,PD,comprising dendrimers poly(amidoamine)(PAMAM)loading dimethylaminododecyl methacrylate(DMADDM)as well as MAO treatment.Here,we explored the chemical properties of the novel compound PD,and proved that this compound was successfully synthesized,with the loading efficiency and encapsulation efficiency of 23.91%and 31.42%,respectively.We further report the two-stage double benefits capability of PD+MAO:(1)in the first stage,PD+MAO could decrease the adherence and development of biofilms by releasing DMADDM in the highly infected first stage after implant surgery both in vitro and in vivo;(2)in the second stage,PD+MAO indicated mighty anti-infection and osteoconductive characteristics in a rat model of peri-implantitis in vivo.This study first reports the two-staged,double benefits of PD+MAO,and demonstrates its potential in clinical applications for inhibiting peri-implantitis,especially in patients with severe infection risk. | Xiaoyu Huang Yang Ge Bina Yang Qi Han Wen Zhou Jingou Liang Mingyun Li Xian Peng Biao Ren Bangcheng Yang Michael D.Weir Qiang Guo Haohao Wang Xinxuan Zhou Xugang Lu Thomas W.Oates Hockin H.K.Xu Dongmei Deng Xuedong Zhou Lei Cheng | 2021 | Bioactive Materials2021，6，12： | 1 |
| 2 | Artemisinins inhibit oral candidiasis caused by Candida albicans through the repression on its hyphal development显示文摘Candida albicans is the most abundant fungal species in oral cavity. As a smart opportunistic pathogen, it increases the virulence byswitching its forms from yeasts to hyphae and becomes the major pathogenic agent for oral candidiasis. However, the overuse ofcurrent clinical antifungals and lack of new types of drugs highlight the challenges in the antifungal treatments because of the drugresistance and side effects. Anti-virulence strategy is proved as a practical way to develop new types of anti-infective drugs. Here,seven artemisinins, including artemisinin, dihydroartemisinin, artemisinic acid, dihydroartemisinic acid, artesunate, artemether andarteether, were employed to target at the hyphal development, the most important virulence factor of C. albicans. Artemisininsfailed to affect the growth, but significantly inhibited the hyphal development of C. albicans, including the clinical azole resistantisolates, and reduced their damage to oral epithelial cells, while arteether showed the strongest activities. The transcriptomesuggested that arteether could affect the energy metabolism of C. albicans. Seven artemisinins were then proved to significantlyinhibit the productions of ATP and cAMP, while reduced the hyphal inhibition on RAS1 overexpression strain indicating thatartemisinins regulated the Ras1-cAMP-Efg1 pathway to inhibit the hyphal development. Importantly, arteether significantlyinhibited the fungal burden and infections with no systemic toxicity in the murine oropharyngeal candidiasis models in vivo causedby both fluconazole sensitive and resistant strains. Our results for the first time indicated that artemisinins can be potentialantifungal compounds against C. albicans infections by targeting at its hyphal development. | Xiaoyue Liang Ding Chen Jiannan Wang Binyou Liao Jiawei Shen Xingchen Ye Zheng Wang Chengguang Zhu Lichen Gou Xinxuan Zhou Lei Cheng Biao Ren Xuedong Zhou | 2023 | International Journal of Oral Science2023，15，4： | 0 |
| 3 | Industry Competitiveness and Complementarity between China and Eurasian Economic Union Countries under the Background of Strategic Docking between Silk Road Economic Belt and the Union显示文摘The implementation of strategic docking between Silk Road Economic Bclt and the Eurasian Economic Union(the Union)is of great significance to facilitate the stable expansion of bilateral trade volume,diversification in major areas of trade,and the continual improvement of technical content level of trade products.This paper first uses the revealed comparative advantage index to study the competitiveness of industries with different technical levels for China and the Union member countries.Then,the trade complementarity and trade integration between China the Union member countries are studied by using the trade complementarity index and trade intensity index.Based on these results,the paper gives some advice on expanding and deepening the bilateral cconomic and trade cooperation. | Xinxuan Cheng Longfei Fan Jiachen Wang | 2019 | China Finance and Economic Review2019，8，1： | 0 |
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