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| 1 | The m6A methylation regulates gonadal sex differentiation in chicken embryo显示文摘Background:As a ubiquitous reversible epigenetic RNA modification,N6-methyladenosine(m6A)plays crucial regulatory roles in multiple biological pathways.However,its functional mechanisms in sex determination and differentiation during gonadal development of chicken embryos are not clear.Therefore,we established a transcriptome-wide m6A map in the female and male chicken left gonads of embryonic day 7(E7)by methylated RNA immunoprecipitation sequencing(MeRIP-seq)to offer insight into the landscape of m6A methylation and investigate the post-transcriptional modification underlying gonadal differentiation.Results:The chicken embryonic gonadal transcriptome was extensively methylated.We found 15,191 and 16,111 m6A peaks in the female and male left gonads,respectively,which were mainly enriched in the coding sequence(CDS)and stop codon.Among these m6A peaks,we identified that 1013 and 751 were hypermethylated in females and males,respectively.These differential peaks covered 281 and 327 genes,such as BMP2,SMAD2,SOX9 and CYP19A1,which were primarily associated with development,morphogenesis and sex differentiation by functional enrichment.Further analysis revealed that the m6A methylation level was positively correlated with gene expression abundance.Furthermore,we found that YTHDC2 could regulate the expression of sex-related genes,especially HEMGN and SOX9,in male mesonephros/gonad mingle cells,which was verified by in vitro experiments,suggesting a regulatory role of m6A methylation in chicken gonad differentiation.Conclusions:This work provided a comprehensive m6A methylation profile of chicken embryonic gonads and revealed YTHDC2 as a key regulator responsible for sex differentiation.Our results contribute to a better understanding of epigenetic factors involved in chicken sex determination and differentiation and to promoting the future development of sex manipulation in poultry industry. | Jianbo Li Xiuan Zhang Xiqiong Wang Congjiao Sun Jiangxia Zheng Junying Li Guoqiang Yi Ning Yang | 2022 | Journal of Animal Science and Biotechnology2022，13，6： | 4 |
| 2 | Effect of silicon carbide additive on microstructure and properties of porcelain ceramics显示文摘 | Anze Shui Xiuan Xi Yanmin Wang Xiaosu Cheng | 2011 | Ceramics International2011，，5： | 2 |
| 3 | Effects of different selenium source on selenium distribution, loin quality and antioxidant status in finishing pigs显示文摘 | XiuAn Zhan Min Wang RuQian Zhao WeiFeng Li ZiRong Xu | 2006 | Animal Feed Science and Technology2006，，3： | 1 |
| 4 | Effects of different selenium source on selenium distribution, loin quality and antioxidant status in finishing pigs显示文摘 | XiuAn Zhan Min Wang | 2007 | Animal Feed Science and Technology2007，132，： | 1 |
| 5 | Effects of different selenium source on selenium distribution, loin quality and antioxidant status in finishing pigs显示文摘 | ZHAN Xiuan WANG Min ZHAO Ruqian | 2007 | Animal Feed Science and Technology2007，132，34： | 1 |
| 6 | Effect of silicon carbide additive on microstructure and properties of porcelain ceramics显示文摘 | Anze Shui Xiuan Xi Yanmin Wang | 2011 | Ceramics International2011，37，： | 1 |
| 7 | Effects of magnesium oxychloride and silicon carbide additives on the foaming property during firing for porcelain ceramics and their microstructure显示文摘 | Xiuan Xi Anze Shui Yunfeng Li Yanmin Wang Hiroya Abe Makio Naito | 2012 | Journal of the European Ceramic Society2012，，12： | 1 |
| 8 | Hereditary retinal degeneration and photoreceptor apoptosis显示文摘 | Liu bin Zhu xiuan | 1998 | Chin Ophthal Res1998，16，3： | 1 |
| 9 | Co-and N-doped carbon nanotubes with hierarchical pores derived from metal-organic nanotubes for oxygen reduction reaction显示文摘Biomolecules with a broad range of structure and heteroatom-containing groups offer a great opportunity for rational design of promising electrocatalysts via versatile chemistry.In this study,uniform folic acid-Co nanotubes(FA-Co NTs) were hydrothermally prepared as sacrificial templates for highly porous Co and N co-doped carbon nanotubes(Co-N/CNTs) with well-controlled size and morphology.The formation mechanism of FA-Co NTs was investigated and FA-Co-hydrazine coordination interaction together with the H-bond interaction between FA molecules was characterized to be the driving force for growth of one-dimensional nanotubes.Such distinct metal-ligand interaction afforded the resultant CNTs rich Co-N_x sites,hierarchically porous structure and Co nanoparticle-embedded conductive network,thus an overall good electrocatalytic activity for oxygen reduction.Electrochemical tests showed that Co-N/CNTs-900 promoted an efficient 4 e ORR process with an onset potential of 0.908 V vs.RHE,a limiting current density of 5.66 mA cm^(-2) at 0.6 V and a H_2 O_2 yield lower than 5%,comparable to that of 20%Pt/C catalyst.Moreover,the catalyst revealed very high stability upon continuous operation and remarkable tolerance to methanol. | Xuewan Wang Xiuan Xi Ge Huo Chenyu Xu Pengfei Sui Renfei Feng Xian-Zhu Fu Jing-Li Luo | 2021 | Journal of Energy Chemistry2021，30，2： | 0 |
| 10 | Unraveling the relationship between Sr stoichiometry in Sr_(x)Fe_(1.5)Mo_(0.5)O_(6)-σ and its catalytic performance for high-temperature CO_(2) electrolysis显示文摘The solid oxide electrolytic cell(SOEC)is one of the most promising energy conversion and storage devices,which could convert CO_(2) to CO with high Faradaic efficiency and production rate.However,the lack of active and stable cathode materials impedes their practical applications.Here we focus on the promising perovskite oxide cathode material Sr_(2)Fe_(1.5)Mo_(0.5)O_(6)-σ,with the aim of understanding how A-atom stoichiometry and catalytic performance are linked.We find that increasing the strontium content in the perovskite improves the chemisorption of CO_(2) on its surface,forming a SrCO_(3) phase.This hinders the charge transfer and oxygen exchange processes.Simulta-neously,strontoium segregation to the cathode surface facilitates coking of the surface during CO_(2) electrolysis,which poisons the electrode.Consequently,a small number of Sr deficiencies are optimal for both electrochemical performance and long-term stability.Our results provide new insights for designing high-performance CO_(2) electrolysis cathode materials. | Xiuan Xi Xiaoyu Liu Lingui Huang Jianwen Liu Bo-Wen Zhang Gadi Rothenberg Xian-Zhu Fu Jing-Li Luo | 2023 | Materials Reports(Energy)2023，3，1： | 0 |
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