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| 1 | Theoretical analysis and experimental investigation on flexural performance of steel reinforced ultrahigh toughness cementitious composite (RUHTCC) beams显示文摘UHTCC (ultrahigh toughness cementitious composite), which is a kind of ultrahigh toughness cemen- titious composites material, exhibits pseudo strain hardening feature when subjected to tension load, and has enormous ductility and prominent crack dispersal ability. Accordingly, UHTCC can improve mechanical behavior of ordinary concrete structure especially its durability, and has been regarded as historical breakthrough to traditional cementitious materials. In this paper, the study focuses on flexure behavior of steel reinforced beam made of UHTCC. Based on the plane section assumption, along with two equilibrium equations of force and moment, the formulae to calculate the flexural load capability for the reinforced ultrahigh toughness cementitious composite (RUHTCC) beam were developed under the assumption that the compression stress- strain relationship in the UHTCC material is a bilinear model. Following this, the simplified formulae were further evolved by effective rectangle stress distribution approach in order to facilitate design of practical engineering. Two effective parameters introduced in effective rectangle approach were determined. The mathematical expressions to evaluate limited rein- forcement ratio, flexural stiffness as well as ductility index were proposed, too. Last, two series of dif- ferent reinforcement ratios of the RUHTCC beams were tested in four-point flexure loading. For com- parison purposes, ordinary RC (reinforced concrete) beams also were prepared. Both moment curva- ture curves and load mid-span displacement curves were recorded and compared with the theoretical calculations. A good agreement between them was found, which validates the proposed theoretical formulae. For ductility index, a slightly big difference between the experimental values and the calcu- lated ones exists. The experimental results show that, compared to control RC beams, the RUHTCC beam can improve both flexural capacity and ductility index, and the degree of improvement will de- crease with the increase in the reinforcement ratio. Particularly, the results also reveal that lager crack width in control beams can be greatly reduced by formation of tightly-spaced fine cracks in UHTCC, which offers more durable structures. | XU ShiLang ZHANG XiuFang | 2009 | Science China(Technological Sciences)2009，52，4： | 18 |
| 2 | The role of ribosomal proteins in the regulation of cell proliferation, tumorigenesis, and genomic integrity显示文摘Ribosomal proteins(RPs), the essential components of the ribosome, are a family of RNA-binding proteins, which play prime roles in ribosome biogenesis and protein translation. Recent studies revealed that RPs have additional extra-ribosomal functions, independent of protein biosynthesis, in regulation of diverse cellular processes. Here, we review recent advances in our understanding of how RPs regulate apoptosis, cell cycle arrest, cell proliferation, neoplastic transformation, cell migration and invasion, and tumorigenesis through both MDM2/p53-dependent and p53-independent mechanisms. We also discuss the roles of RPs in the maintenance of genome integrity via modulating DNA damage response and repair. We further discuss mutations or deletions at the somatic or germline levels of some RPs in human cancers as well as in patients of Diamond-Blackfan anemia and 5q- syndrome with high susceptibility to cancer development. Moreover, we discuss the potential clinical application, based upon abnormal levels of RPs, in biomarker development for early diagnosis and/or prognosis of certain human cancers. Finally, we discuss the pressing issues in the field as future perspectives for better understanding the roles of RPs in human cancers to eventually benefit human health. | Xilong Xu Xiufang Xiong Yi Sun | 2016 | Science China(Life Sciences)2016，59，7： | 13 |
| 3 | Milling surface roughness for 7050 aluminum alloy cavity influenced by nozzle position of nanofluid minimum quantity lubrication显示文摘In nanofluid minimum quantity lubrication(NMQL)milling of aviation aluminum alloy,it is the bottleneck problem to adjust the position parameters(target distance,incidence angle,and elevation angle)of the nozzle to improve the surface roughness of milling,which has large and uncontrollable errors.In this paper,the influence law of milling cutter speed,helical angle,and cavity shape on the flow field around the milling cutter was studied,and the optimal nozzle profile parameters were obtained.Using 7050 aluminum alloy as the workpiece material,the milling experiment of the NMQL cavity was conducted by utilizing cottonseed oil-based Al2 O3 nanofluid.Results show that the high velocity of the surrounding air flow field and the strong gas barrier could be attributed to high rotating velocities of the milling cutter.The incidence angle of the nozzle was consistent with the helical angle of the milling cutter,the target distance was appropriate at 25–30 mm,and the elevation angle was suitable at 60°–65°.The range and variance analyses of the signal-to-noise ratio of milling force and roughness were performed,and the chip morphology was observed and analyzed.The results show that the optimal combination of nozzle position parameters was the target distance of 30 mm,the incidence angle of 35°,and the elevation angle of 60°.Among these parameters,target distance had the largest impact on cutting performance with a contribution rate of more than 55%,followed by incidence angle and elevation contribution rate.Analysis by orthogonal experiment revealed that the nozzle position parameters were appropriate,and Ra(0.087 lm)was reduced by 30.4%from the maximum value(0.125 lm).Moreover,Rsm(0.05 mm)was minimum,which was 36%lower than that of the seventh group(Rsm=0.078 mm). | Zhenjing DUAN Changhe LI Yanbin ZHANG Lan DONG Xiufang BAI Min YANG Dongzhou JIA Runze LI Huajun CAO Xuefeng XU | 2021 | Chinese Journal of Aeronautics2021，34，6： | 10 |
| 4 | Pre-peak on the structure factor of liquid hypoeutectic Al-Fe alloy显示文摘Using a θ-θ X ray diffractometer the structure of liquid hypoeutectic Al Fe alloy at 675℃ and its change with different thermal histories are investigated . Liquid Al is used as a reference system. It is found that a pre peak appears on the small angle part of the structure factor of the nonsuperheated hypoeutectic Al Fe alloy, but disappears after superheating whereas the structure factors of liquid Al hardly change with the different thermal histories, and no pre peak can be observed on them. The appearance of a pre peak is a mark of the intermediate range order (IRO). The pre peak is taken as the correlation between Fe atoms on the IRO length scale. Assume that the crystalline structure is the first order approximation of the liquid structure. A model structure is constructed. The basic unit is a cube formed by 8 Al atoms on its corner and one Fe atom occupying its center. The translation of such a unit along its fourbody diagonals by the length of a diagonal can meet the requirement of the Fe_Fe distance and gives a DO 3 like structure. If the vacancy among the units is filled with fcc like Al cells, the composition of the entity is about Al 7Fe, close to that of the metastable phase Al 6Fe from rapid solidification. It is speculated that there are Al 6Fe like clusters in the liquid hypoeutectic Al Fe alloy. | Jingyu Qin Xiufang Bian Weimin Wang Jiaji Ma Changye Xu | 1998 | Chinese Science Bulletin1998，43，14： | 7 |
| 5 | Improved performance of aluminum pigments encapsulated in hybrid inorganic-organic films显示文摘An organic silane acrylate resin(PMBK) was synthesized by free-radical solution polymerization using methyl methacrylate,butyl acrylate and(3-methacryloxypropyl)trimethoxysilane as monomers.Aluminum(Al) particles were then encapsulated in inorganic-organic hybrid films that were prepared by hydrolysis and condensation of PMBK and tetraethyl orthosilicate(TEOS) on the surface of Al pigments.Characterization results showed that PMBK and TEOS could simultaneously hydrolyze and condense with hydroxyl groups on the surface of the Al particles to form composite Al particles coated with inorganic-organic hybrid films.Compared with raw Al particles,the corrosion resistance and adhesive properties of paint films containing the composite Al particles were improved greatly,while the glossiness of the paint films decreased slightly,from 48.6° to 47.0°.In alkaline media(pH 11),the volume of evolved H_2 of composite Al particles was only 3.5 mL,whereas that of raw Al was 83.5 mL.The glossiness of paint films containing composite Al particles decreased by 1.66%after immersion in alkaline media for24 h,whereas that of raw Al decreased by 14.82%.Peel-off tests of the paint films showed that the composite particles moved slightly away from the paint films.In contrast,the raw Al particles were seriously desquamated,suggesting encapsulation of hybrid films can greatly improve the adhesive properties of Al particles in paint films. | Pihui Pi Chao Liu Xiufang Wen Lianfu Zheng Shouping Xu Jiang Cheng | 2015 | Particuology2015，13，2： | 5 |
| 6 | Fine Machining of Large-Diameter 6H-SiC Wafers显示文摘大直径的 6H-SiC 晶片的三主要用机器制造进程在这篇论文被介绍。这些过程包括切,舔并且擦亮。舔的原因伟人剩余压力和能与随后的擦亮的过程逐渐地被减少的深损坏层。机械擦亮准备的表面(MP ) 出现了有 5-8 nm 的深度的很多擦伤。这些擦伤能被 chemo-mechanicalpolishing (CMP ) 有效地移开。在 CMP 以后,有粗糙 R_a=0.3 nmwas 的极其光滑、低的损坏层表面获得了。原子力量显微镜学(AFM ) 和光显微镜学被用来观察到样品和高分辨率 X 光检查衍射计(HRXRD ) 的表面形态学被用于表面下的区域的水晶格子完美。表面剩余压力的变化被 HRXRD 在用机器制造过程期间调查。 | Xiufang CHEN Juan LI Deying MA Xiaobo HU Xiangang XU Minhua JIANG | 2006 | Journal of Materials Science & Technology2006，22，5： | 4 |
| 7 | Surface Polishing of 6H-SiC Substrates显示文摘为硅碳化物擦亮的表面(原文如此)底层被调查 andresults 为机械擦亮被介绍( MP )并且chemo机械的擦亮( CMP ) .High qualitysurfaces 在 CMP 期间在物理的 MP anddetailed 和化学过程与擦伤的胶体的 silica.The 移动机制在 CMP 以后被获得是 MP 和 CMP 的 analyzed.The 效果在 thesurface 上,粗糙被光显微镜学( OM )估计,原子力量显微镜学( AFM )和高分辨率 | Xiufang CHEN Xiangang XU Juan LI Shouzhen JIANG Lina NING Yingmin WANG Deying MA Xiaobo HU Minhua JIANG | 2007 | Journal of Materials Science & Technology2007，23，3： | 4 |
| 8 | Vacuum carburization of 12Cr2Ni4A low carbon alloy steel with lanthanum and cerium ion implantation显示文摘As bearing parts, 12 Cr2 Ni4 A is expected to have high hardness and excellent fatigue strength, so carburizing is employed to improve the inherit properties of 12 Cr2 Ni4 A. However, the traditional carburizing is limited by poor microstructure distribution and low rate of carburizing. The rare earth ion implantation is known to help improving the properties of tribology, corrosion resistance and oxidation resistance of metal. In this article, the RE implantation is employed to assist the carburizing. Lanthanum and cerium ion implantations are initially used to assist 12 Cr2 Ni4 A low pressure vacuum carburization.The microstructure, content of retained austenite, hardness, thickness of layer and carbon diffusion were analyzed by optical microscopy(OM), scanning electron microscopy(SEM), X-ray diffraction(XRD) and Rockwell/Vickers hardness tester, respectively. It was shown that lanthanum and cerium implantations can improve structure of the vacuum carburizing layer, and enhance the uniformity of carbon element distribution on the carburized surface. Meanwhile the RE implantation plays a positive role in promoting the surface hardness and carburized rate. The lanthanum element has more significant effect on surface hardness and content of retained austenite than cerium element. The surface hardness of lanthanum element implanted layer was 62.9 HRC with 9.6% content of retained austenite, while the carburizing rate of cerium implanted layer increased by 12.4%. | Meiling Dong Xiufang Cui Yuhui Zhang Guo Jin Caiwen Yue Xin Zhao Zhaobing Cai Binshi Xu | 2017 | Journal of Rare Earths2017，35，11： | 3 |
| 9 | Low-Angle Grain Boundaries in Sublimation Grown 6H-SiC Crystals显示文摘High-resolution X-ray diffractometry (HRXRD) was used to assess the quality of 6H-SiC crystals grown by sublimation method. The results show the occurrence of low-angle grain boundaries (LB) is close relative to the inclination of the crystal interface. At the central faceted region with 0° inclination the crystal is of high structural perfection. However, at the region close to the facet with less than 5° inclination LB occurs slightly and at the region close to the peripheral polytype ring with more than 5° inclination LB defect occurs heavily. The density of LB can be drastically reduced by decreasing radial temperature gradient that determines the shape of the crystal growth interface. | Jiang Shouzhen Li Xianxiang Dong Jie Chen Xiufang Xu Xiangang Hu Xiaobo | 2006 | Journal of Rare Earths2006，24，z1： | 3 |
| 10 | The receptor-like cytosolic kinase RIPK activates NADP-malic enzyme 2 to generate NADPH for fueling ROS production显示文摘Reactive oxygen species(ROS)production is a conserved immune response in Arabidopsis primarily medi-ated by respiratory burst oxidase homolog D(RBOHD),a nicotinamide adenine dinucleotide phosphate(NADPH)oxidase associated with the plasma membrane.A rapid increase in NADPH is necessary to fuel RBOHD proteins and thus maintain ROS production.However,the molecular mechanism by which NADPH is generated to fuel RBOHD remains unclear.In this study,we isolated a new mutant allele of FLAGELLIN-INSENSITIVE 4(FIN4),which encodes the first enzyme in de novo NAD biosynthesis.fin4 mu-tants show reduced NADPH levels and impaired ROS production.However,FIN4 and other genes involved in NAD-and NADPH-generating pathways are not highly upregulated upon elicitor treatment,raising a pos-sibility that a cytosolic NADP-linked dehydrogenase might be post-transcriptionally activated to maintain the NADPH supply close to RBOHD.To verify this possibility,we isolated the proteins associated with RPM1-INDUCED PROTEIN KINASE(RIPK),a receptor-like cytoplasmic kinase that regulates broad-spectrum ROS signaling in plant immunity,and identified NADP-malic enzyme 2(NADP-ME2),an NADPH-generating enzyme.Compared with wild-type plants,nadp-me2 mutants display decreased NADP-ME activity,lower NADPH levels,and reduced ROS production in response to immune elicitors.Furthermore,we found that RIPK can directly phosphorylate NADP-ME2 and enhance its activity in vitro.The phosphorylation of the NADP-ME2 S371 residue contributes to ROS production upon immune elicitor treatment and susceptibility to the necrotrophic bacterium Pectobacterium carotovorum.Collectively,our study suggests that RIPK phosphorylates and activates NADP-ME2 to rapidly increase cytosolic NADPH,thus fueling RBOHD to sustain ROS production in plant immunity. | Binyan Wu Ping Li Xiufang Hong Cuihong Xu Ran Wang Yan Liang | 2022 | Molecular Plant2022，15，5： | 2 |
| 11 | A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer显示文摘Protein neddylation is catalyzed by a neddylation activating enzyme(NAE,E1),an E2 conjugating enzyme,and an E3 ligase.In various types of human cancers,the neddylation pathway is abnormally activated.Our previous study validated that the neddylation E2 UBE2F is a promising therapeutic target in lung cancer.Although the NAE inhibitor MLN4924/pevonedistat is currently under clinical investigation as an anti-cancer agent,there are no small molecules available that selectively target UBE2F.Here,we report,for the first time,the discovery,via structure-based virtual screen and chemical optimization,of such a small molecule,designated as HA-9104.HA-9104 binds to UBE2F,reduces its protein levels,and consequently inhibits cullin-5 neddylation.Blockage of cullin-5 neddylation inactivates cullin-RING ligase-5(CRL5)activity,leading to accumulation of the CRL5 substrate,NOXA,to induce apoptosis.Moreover,HA-9104 appears to form the DNA adduct via its 7-azaindole group to induce DNA damage and G2/M arrest.Biologically,HA-9104 effectively suppresses the growth and survival of lung cancer cells and confers radiosensitization in both in vitro cell culture and in vivo xenograft tumor models.In summary,we discovered a small molecule,designated HA-9104,that targets the UBE2F-CRL5 axis with anti-cancer activity alone or in combination with radiation. | Tiantian Xu Qisheng Ma Yanan Li Qing Yu Peichen Pan Yawen Zheng Zhijian Li Xiufang Xiong Tingjun Hou Bin Yu Hongmin Liu Yi Sun | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 2 |
| 12 | Systematic Investigation of the Molecular Behaviors of Heterofullerenes C48X2 (X=B,N)显示文摘 | Xing Yumei Shang Zhenfeng | 2003 | Chemical Physics2003，287，3： | 1 |
| 13 | Theoretical Studies of the Substitution Patterns of Boron-Nitrogen (BN) Fullerenes:From C50 up to C20B15N15 CBN Ball显示文摘 | Shang Zhenfeng Wang Guichang | 2005 | Journal of Physical Chemistry A2005，109，： | 1 |
| 14 | Preservation of kiwifruit coated with an edible film at ambient temperature 显示文摘 | Shiying Xu Xiufang Chen Da Wen Sun | 2001 | Journal of Food Engineering2001，50，4： | 1 |
| 15 | A comparative study on five approaches to evaluate double-K fracture toughness parameters of concrete and size effect analysis 显示文摘 | Xiufang Zhang Shilang Xu | 2011 | Engineering Fracture Mechanics2011，137，11： | 1 |
| 16 | Preservation of kiwifruit coated with an edible fdm at ambient temperature 显示文摘 | XU SHIYING CHEN XIUFANG | 2001 | Jour- nal of FoodEngineefing2001，，12： | 1 |
| 17 | Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce autophagy显示文摘Protein neddylation is catalyzed by a three-enzyme cascade,namely an E1 NEDD8-activating enzyme(NAE),one of two E2 NEDD8 conjugation enzymes and one of several E3 NEDD8 ligases.The physiological substrates of neddylation are the family members of cullin,the scaffold component of cullin RING ligases(CRLs).Currently,a potent E1 inhibitor,MLN4924,also known as pevonedistat,is in several clinical trials for anti-cancer therapy.Here we report the discovery,through virtual screening and structural modifications,of a small molecule compound HA-1141 that directly binds to NAE in both in vitro and in vivo assays and effectively inhibits neddylation of cullins 1 e5.Surprisingly,unlike MLN4924,HA-1141 also triggers non-canonical endoplasmic reticulum(ER)stress and PKR-mediated terminal integrated stress response(ISR)to activate ATF4 at an early stage,and to inhibit protein synthesis and mTORC1 activity at a later stage,eventually leading to autophagy induction.Biologically,HA-1141 suppresses growth and survival of cultured lung cancer cells and tumor growth in in vivo xenograft lung cancer models at a well-tolerated dose.Taken together,our study has identified a small molecule compound with the dual activities of blocking neddylation and triggering ER stress,leading to growth suppression of cancer cells. | Yanan Li Chaorong Wang Tiantian Xu Peichen Pan Qing Yu Lei Xu Xiufang Xiong Tingjun Hou Sunliang Cui Yi Sun | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 1 |
| 18 | Synthesis and characterization of fluorine-containing poly-styrene-acrylate latex with core-shell structure using a reactive surfactant显示文摘 | Xu Guilong Deng Lili Wen Xiufang | | 0，，03： | 1 |
| 19 | Fuzzy space periodic symmetries for polyynes and their cyano-compounds显示文摘 | Xuezhuang Zhao Zhengfeng Shang Guichang Wang Xiufang Xu Ruifang Li Yinming Pan Zucheng Li | 2008 | Journal of Mathematical Chemistry2008，，3： | 1 |
| 20 | Preservation of kiwifruit coated with an edible film at ambient temperature显示文摘 | XU Shiying CHEN Xiufang SUN Dawen | 2001 | Journal of Food Engineering2001，50，4： | 1 |
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