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您的检索式：作者名="Xiufeng Chang"
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| 1 | Effect of soothing liver therapy on oocyte quality and growth differentiation factor-9 in patients undergoing in vitro fertilization and embryo transfer显示文摘OBJECTIVE:To investigate the effect of Soothing liver therapy on infertile women undergoing in vitro fertilization and embryo transfer(IVF-ET)and to explore its mechanism.METHODS:Fifty-eight women with tubal infertility were randomized into two groups:30 in an experimental group treated with Xiaoyao powder(Shugan)plus gonadotropin-releasing hormone analog(GnRHa)/follicle-stimulating hormone(FSH)/human chorionic gonadotropin(hCG)and 28 in the control group who were treated with GnRHa/FSH/hCG only.The total gonadotropin(Gn)doses required,endometrial thickness,oocyte numbers,high quality embryo production rate and pregnancy rate of the two groups were compared.The concentration of growth differentiation factor-9(GDF-9)in follicular fluid was detected by western blotting and the expression of GDF-9 mRNA in granulosa cells was measured using reverse tran-scription-polymerase chain reaction amplification.RESULTS:In the experimental group,the Gn dose was significantly lower than that in the control group;the endometrial thickness,high quality embryo production and pregnancy rates were significantly higher and the expression of GDF-9 mRNA was also significantly higher than in the control group(all P<0.05).CONCLUSION:Shugan treatment can improve the pregnancy rate of women with tubal infertility;its mechanism is possibly related to the increased expression of GDF-9 in granulosa cells. | Xing Gao Xiufeng Chang Huilan Du Min Zhang Jianping Zhang Aiping Zhu | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 11 |
| 2 | Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment显示文摘Salmonella:mediated cancer therapy has achieved remarkable anti-tumor effects in experimental animal models,but the detailed mechanism remains unsolved.In this report,the active involvement of the host immune response in this process was confirmed by comparing the tumor-suppressive effects of Salmonella in immunocompetent and immunodeficient mice bearing melanoma allografts.Since flagella are key inducers of the host immune response during bacterial infection,flagella were genetically disrupted to analyse their involvement in Salmonella-mediated cancer therapy.The results showed that flagellum-deficient strains failed to induce significant anti-tumor effects,even when more bacteria were administered to offset the difference in invasion efficiency.Flagella mainly activate immune cells via Flagellin/Toll-like receptor 5(TLR5)signalling pathway.Indeed,we showed that exogenous activation of TLR5 signalling by recombinant Flagellin and exogenous expression of TLR5 both enhanced the therapeutic efficacy of flagellum-deficient Salmonella against melanoma.Our study highlighted the therapeutic value of the interaction between Salmonella and the host immune response through Flagellin/TLR5 signalling pathway during Salmonella-mediated cancer therapy,thereby suggesting the potential application of TLR5 agonists in the cancer immune therapy. | Jianxiang Chen Yiting Qiao Guo Chen Cunjie Chang Heng Dong Bo Tang Xiawei Cheng Xiufeng Liu Zichun Hua | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 6 |
| 3 | The greedy nature of mutant RAS: a boon for drug discovery targeting cancer metabolism?显示文摘地岬 oncogene 变化经常在人的癌症被检测。在调停地岬的 tumorigenesis 之中,驾驶 KRAS 的癌症是经常诊断的大多数并且对当前的治疗抵抗。尽管有超过三十年集中的努力,仍然为变异的地岬蛋白质没有特定的治疗。当试着堵住那些生长得很好的下游的小径时,例如 RAF-MAPK 小径和 PI3K-AKT 小径,注意在新陈代谢的小径和可行性上对地岬的潜在的效果被给予了为指向这些小径。最近的研究证明了那地岬不仅支持氧气的 glycolysis 和夫酸安新陈代谢 reprograming 提供精力,而且它也便于分叉的新陈代谢小径, autophagy,和 macropinocytosis。这些改变为肿瘤生长产生积木并且在肿瘤房间加强抗氧化剂防卫。所有这些新陈代谢的变化遇见地岬驱动的癌症的不同要求,从正常房间使他们不同。确实,一些成就被做了通过指向特定的新陈代谢在现出症状之前的潜的模型给换新电线禁止肿瘤生长。尽管仍然有阐明的一条长路改变的新陈代谢的风景,我们相信特定的新陈代谢的酶或小径能治疗学地为地岬驱动的癌症的选择抑制被指向。 | Jing Lv Jieqiong Wang Siyu Chang Mingyao Liu Xiufeng Pang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，1： | 1 |
| 4 | InSAR atmospheric distortions mitigation:GPS observations and NCEP FNL data显示文摘 | Liang Chang Xiufeng He | | 0，，73： | 1 |
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