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您的检索式：作者名="Xiujun Cheng"
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| 1 | Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors. | Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang | 2022 | Cell Research2022，32，11： | 2 |
| 2 | SOLVING NONLINEAR DELAY-DIFFERENTIAL-ALGEBRAIC EQUATIONS WITH SINGULAR PERTURBATION VIA BLOCK BOUNDARY VALUE METHODS显示文摘Block boundary value methods(BBVMs)are extended in this paper to obtain the numerical solutions of nonlinear delay-differential-algebraic equations with singular perturbation(DDAESP).It is proved that the extended BBVMs in some suitable conditions are globally stable and can obtain a unique exact solution of the DDAESP.Besides,whenever the classic Lipschitz conditions are satisfied,the extended BBVMs are preconsistent and pth order consistent.Moreover,through some numerical examples,the correctness of the theoretical results and computational validity of the extended BBVMs is further confirmed. | Xiaoqiang Yan Xu Qian Hong Zhang Songhe Song Xiujun Cheng | 2023 | Journal of Computational Mathematics2023，41，4： | 0 |
| 3 | Local Ordering Process of (Fe_(25)Ni_(75))_(77)Si_(13)B_(10) Amorphous Alloy Under Annealing显示文摘In this paper the relaxation behavior of resistance,of temperature coefficient of electrical resistance and of magnetic Curie temperature on(Fe_(25)Ni_(75))_(77)Si_(13)B_(10) amorphous alloy in a temperature range from 150℃ to 400℃ is presented.Having analyzed the possible relaxation mechanism,we proposed a few kinds of local ordering process in the course of annealing.The development of some local ordering processes and the relation between them are analyzed. | WU Qingping SHEN Zhongyi YIN Xiujun CHENG Xian’an WANG Xuwei | 1992 | Chinese Physics Letters1992，9，5： | 0 |
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