|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The role of transcriptional factor D-site-binding protein in circadian CCL2 gene expression in anti-Thy1 nephritis显示文摘Mesangial proliferative glomerulonephritis(MsPGN)is an inflammatory disease,but both the nature of disease progression and its regulation remain unclear.In the present study,we monitored the course of anti-Thy1 nephritis from days 1 to 5 and established gene expression profiles at each time point using microarrays to explore the development of inflammation.According to the gene expression profiles,macrophage infiltration(triggered by CCL2 activation)was evident on day 1 and enhanced inflammation over the next few days.We screened for genes with expression levels similar to CCL2 and found that the upregulation of the circadian gene albumin D-site-binding protein(DBP)was involved in CCL2 activation in mesangial cells.More importantly,CCL2 expression showed oscillatory changes similar to DBP,and DBP induced peak CCL2 expression at 16:00 a clock on day 1 in the anti-Thy1 nephritis model.We knocked down DBP through transfection with a small interfering RNA(siRNA)and used RNA sequencing to identify the DBP-regulated TNF-α-CCL2 pathway.We performed chromatin immunoprecipitation sequencing(ChIP-Seq)and the dual luciferase assay to show that DBP bound to the TRIM55 promoter,regulating gene expression and in turn controlling the TNF-α-CCL2 pathway.In conclusion,DBP-regulated circadian CCL2 expression by the TRIM55-TNF pathway in injured mesangial cells at an early stage,which promoted macrophage recruitment and in turn triggered infiltration and inflammation in a model of anti-Thy1 nephritis. | Yang Lu Yan Mei Lei Chen Lingling Wu Xu Wang Yingjie Zhang Bo Fu Xizhao Chen Yuansheng Xie Guangyan Cai Xueyuan Bai Qinggang Li Xiangmei Chen | 2019 | Cellular & Molecular Immunology2019，16，9： | 7 |
| 2 | Experimental study of vapor local characteristics in upward low pressure boiling tube显示文摘Radial distribution of vapor local parameters, including local void fraction, interfacial velocity, bubblesize, bubble frequency and interfacial area concentration, are investigated through the measurement in an upwardboiling tube using dual-sensor optical probe. In addition, a new local parameter -'local bubble number concentra-tion' is developed on the basis of bubble frequency. The analysis shows that this parameter can reflect bubble numberdensity in space, and has clear physical meaning. | SUNQi ZHAOHua XIZhao YANGRui-Chang | 2003 | Nuclear Science and Techniques2003，14，3： | 7 |
| 3 | Efficacy of extracorporeal shock wave lithotripsy for ureteral stones in children显示文摘 | Jianlin Lu Xizhao Sun Lei He Ying Wang | 2009 | Pediatric Surgery International2009，，12： | 1 |
| 4 | Fuzzy linear regression analysis显示文摘 | | 1992 | Fuzzy Sets and System1992，51，： | 1 |
| 5 | Fuzzy Linear Regression Analysis显示文摘 | WANG Xizhao HA Minghu | 1992 | Fuzzy Sets and Systems 511992，11，4： | 1 |
| 6 | FRSVMs: Fuzzy rough set based support vector machine显示文摘 | Chen Degang He Qiang Wang Xizhao | 2010 | Fuzzy Sets and Systems2010，161，4： | 1 |
| 7 | Improving Fuzzy Cmean Clustering Based on Feature-weight Learning显示文摘 | Wang Xizhao Wang Yadong Wang Lijuan | 2004 | Pattern Recognition Letters2004，25，10： | 1 |
| 8 | Optimal volt/var control in distribution systems显示文摘 | Yutian Liu Peng Zhang Xizhao Qiu | 2002 | International Journal of Electrical Power and Energy Systems2002，，4： | 1 |
| 9 | Sequences of (S)fuzzy integral functions显示文摘 | HA Minghu WANG Xizhao YANG Lanzhen | 2003 | Fuzzy Sets and Systems2003，138，： | 1 |
| 10 | Infrared spectroscopic analysis of urinary stones (including stones induced by melamine-contaminated milk powder) in 189 Chinese children显示文摘 | Sun Xizhao Shen Luming Cong Xiaoming | 2011 | Journal of Pediatric Surgery2011，46，4： | 1 |
| 11 | Optimal Volt/Var Con- trol in Distribution Systems显示文摘 | Yutian Liu Peng Zhang Xizhao Qiu | 2002 | International Journal of Elec- trical Power& Energy Systems2002，，24： | 1 |
| 12 | Efficacy of extracorporeal shock wave lithotripsy for ureteral stones in chidren 显示文摘 | LU JIANLIN SUN XIZHAO HE LEI | 2009 | Pediatr Surg Int2009，25，12： | 1 |
| 13 | Improving Fuzzy C- means Clustering Based on Feature-weight Learn- ing显示文摘 | Wang Xizhao Wang Yadong | 2004 | Pattern Recognition Letters2004，25，： | 1 |
| 14 | A new and informative active learning approach for support vector machine显示文摘 | Lisha Hu Shuxia Lu Xizhao Wang | 2013 | Information Sciences2013，，： | 1 |
| 15 | Fuzzy Linear Regression Analysis显示文摘 | Ha Minghu | 1992 | Fuzzy Sets and Systems1992，，51： | 1 |
| 16 | Comparison of re- nal function and metabolic abnormalities of cystine stone patients and Calcium oxalate stone patients in China显示文摘 | SHEN Luming SUN Xizhao ZHU Huaijun | 2013 | World Journal of Urology2013，31，5： | 1 |
| 17 | Concise synthesis and antimicrobial activities of new substituted 5- isoxazolpenicillins 显示文摘 | Wang xizhao Jia jiong Wang jianwu | 2007 | J Chin Chem Soc2007，54，： | 1 |
| 18 | Nested structure in parameterized rough reduction显示文摘 | Zhao Suyun Wang Xizhao Chen Degang | 2013 | Information Sciences2013，248，： | 1 |
| 19 | Improving fuzzy C-means clustering based on feature-weight learn-ing显示文摘 | Wang Xizhao Wang Yadong Wang Lijuan | 2004 | Pattern Recognition Letters2004，25，10： | 1 |
| 20 | Learning optimition in simplifying fuzzy rules显示文摘 | Xizhao Wang Jiarong Hong | 1999 | Fuzzy sets and systems1999，，106： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员